RESUMO
PURPOSE: To describe two cases of retinal angiomatous proliferation (RAP)-like lesion following radiation therapy for primary tumor. PATIENTS AND METHODS: Retrospective evaluation of two patients with previous irradiation treatment for a pleomorphic adenoma of the lacrimal gland and a vocal cord carcinoma, respectively. Visual acuity (VA), fluorescein angiography and optical coherence tomography were performed and demonstrated a RAP-like lesion in both cases. Treatment with intravitreal injections of Ranibizumab was performed with a follow-up of 19 and 10 months, respectively. RESULTS: Both the patients had a positive response to the treatment with improvement in VA and reduction of intraretinal fluid. CONCLUSION: RAP-like lesions can develop following radiation treatment for a primary tumor. In patients presenting with idiopathic RAP, a history of prior radiotherapy should be considered.
Assuntos
Lesões por Radiação/etiologia , Radioterapia/efeitos adversos , Retina/efeitos da radiação , Neovascularização Retiniana/etiologia , Adenoma Pleomorfo/patologia , Adenoma Pleomorfo/radioterapia , Idoso de 80 Anos ou mais , Inibidores da Angiogênese/uso terapêutico , Anticorpos Monoclonais Humanizados/uso terapêutico , Neoplasias Oculares/patologia , Neoplasias Oculares/radioterapia , Feminino , Angiofluoresceinografia , Humanos , Doenças do Aparelho Lacrimal/patologia , Doenças do Aparelho Lacrimal/radioterapia , Neoplasias Laríngeas/patologia , Neoplasias Laríngeas/radioterapia , Masculino , Lesões por Radiação/diagnóstico , Lesões por Radiação/tratamento farmacológico , Ranibizumab , Neovascularização Retiniana/diagnóstico , Neovascularização Retiniana/tratamento farmacológico , Estudos Retrospectivos , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia , Prega Vocal/efeitos da radiaçãoRESUMO
BACKGROUND/AIMS: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD). METHODS: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T and anti-inflammatory IL10 -1082G/A cytokine polymorphisms using the 5' nuclease TaqMan(R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies. RESULTS: The -251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls (p = 0.037, OR = 1.21, 95% CI = 1.01 to 1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (corrected p value = 0.043, OR = 1.23, 95% CI = 1.0 to 1.50). CONCLUSION: The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.