Effects of Rhubarb Extract on Calcium Dissolved Quantity in Demineralized Enamel / 国际中医中药杂志

Objective To observe effects of rhubarb extract on Ca dissolved quantity in demineralized enmnel. Methods Demineralization was performed after treating tooth facing with rhubarb extract of different concentrations and deionized water. The concentration of Ca was detected by ASCA biochemical analyzer after demineralization. Results Dissolved quantity of demineralized Ca in the rhubarb extract group (2 mg/ml, 4mg/ml) was significantly lower than that of the deionized water group (P<0.01) and the rhubarb extract group (1 mg/ml) (P<0.05), but higher than that of 2% sodium fluoride group (P>0.05). Dissolved quantity of demineralized Ca in the rhubarb extract (1 mg/ml) group was significantly higher thanthat of 2% sodium fluoride group (P<0.01), but lower than that of the deionized water group(P>0.05).Conclusion The rhubarb exwact (2mg/ml, 4mg/ml) can inhibit Ca dissolution in demineralized enamel.The inidal effective concentration of rhubarb extract is 2 mg/ml.

Clinical Observation on Treatment of 92 Cases of Oral Ulcer with Compound Huanglian Powder / 国际中医中药杂志

Objective To observe cfinical effect of compound huanglian powder treating oral ulcer.Methods 92 patients with oral ulcer were randomly divided into a treatment group and a control group.The treatment group was treated with compound Huanglian powder,and the control group was treated with metronidazole.The therapeutic effects were observed in 2 months of following up after taking the medicines for one month.Results Effects on oral ulcer of the treatment group were obviously superior to those of the control group.which had a significant difference(P＜0.05).Conclusion The treatrment of compound Huanglian powder on oral ulcer was better than metronidazole.

Clinical Application of Magnolia Officinalis and Artemisia Capillaris on Preventing Caries in 67 Cases / 国际中医中药杂志

Objective To observe preventive effect of magnolia officinalis and artemisia capillaris on caries.Methods 67 patients with caries were randomly divided into a prevention group and a control group.After molar removal with traditional methods.the prevention group was given decoction of magnolia officinalis and artemisia capillaris,while the control group was given metronidazole.They were followed up for 3 months so as to observe its recurrence rate and adverse reaction.Results Effect of the prevention group on preventing caries was markedly superior to that of the control group(P＜0.05).Conclusion.The efficacy of magnolia officinalis and artemisia capillaris exerts a better effect than metronidazole.It's worth to promote application clinically.

Long-term variations in mechanical properties and in vivo degradability of CPC/PLGA composite.

A new type of bone cement composite was successfully achieved by mixing degradable biosecure polylactic-co-glycolic acid (PLGA) fibers with high initial strength calcium phosphate cement (CPC). Its higher initial strength was mainly responsible for the in situ reinforcing effect of residual tetra-calcium phosphate monoxide (r-TTCP) particles reported in our previous work. So this bone cement composite containing fibers and the controlling group could be termed as CPC/PLGA composite and pure CPC or fiber-free group, respectively. In this study, we had investigated mechanical properties and microstructures of the CPC/PLGA composite immersed in 0.9% saline solution for different time and its in vivo degradation behaviors after implanting in rabbit muscle and femur bone, respectively. Results showed that the incorporation of the degradable fibers not only greatly increased the initial toughness and flexural strength of the CPC/PLGA composite but also significantly improved its later osteo-conduction as well as degradation rate. The rabbit muscle implant tests showed that the weight loss ratio of the CPC/PLGA composite increased by 41.03% as compared to the pure CPC. And the rabbit femur implant tests showed that the composite exhibits outstanding biocompatibility and bioactivity and more excellent osteoconduction and degradability than the pure CPC.

Physicochemical properties of TTCP/DCPA system cement formed in physiological saline solution and its cytotoxicity.

In this paper, the physicochemical properties and cytotoxicity of calcium phosphate cement (CPC), prepared by mixing cement powders of tetracalcium phosphate (TTCP) and dicalcium phosphate (DCPA) with a cement liquid of physiological saline solution, were investigated. The microstructure evolution of various hardened cement bodies and their hydration crystals as a function of immersion time in similar physiological fluids, physiological saline solution (0.9% NaCl), or simulated body fluids (SBF), were also studied. Results show that the setting time of CPC is in the range of 12-15 min, which meets the clinical application demands. We also found that the mean compressive strength of the CPC samples immersed in SBF for 3 days is 104+/-10 MPa which reaches the transverse compressive strength, 106-133 MPa, of human long bone. The results obtained from both the X-ray powder diffraction analyses (XRD) and scanning electron microscopy (SEM) observations indicated that a reinforcing effect of some remaining TTCP particles in the early stages of immersion is mainly responsible for the increase in the initial strength. Although the CPC failed to keep this high level when immersed for a longer time, the initial reinforcing effect of the remaining TTCP particles provides advantages for clinical applications. This would be effective when the material is loaded at the very beginning of the implantation, especially for the material used as a fixation, which requires a certain initial strength in the early stages of the implantation. The cytotoxicity results showed that the relative growth rate (RGR%) of L929 cells on the CPC samples using physiological saline solution as a cement liquid was slightly superior to that of the samples using the 0.5 mol/L phosphate acid solution as the cement liquid. This was most likely caused by the pH difference between the two CPC samples immersed in a DMEM-BFS medium.