RESUMO
This observation reports that a hepatitis B virus (HBV) reactivation, as the result of hepatitis C virus (HCV) eradication on a dominant HCV coinfected HBV/HCV patient, was subsequently prevented by treating both viral infections together. This finding raises the question as to whether preemptive HBV treatment should be prescribed along with HCV treatment to prevent HBV from being reactive after HCV eradication in coinfected HBV/HCV patients.
Assuntos
Adenina/análogos & derivados , Antivirais/uso terapêutico , Vírus da Hepatite B/fisiologia , Hepatite B/prevenção & controle , Hepatite C/tratamento farmacológico , Organofosfonatos/uso terapêutico , Ativação Viral/efeitos dos fármacos , Adenina/uso terapêutico , Adulto , Portador Sadio/tratamento farmacológico , Portador Sadio/virologia , Quimioterapia Combinada , Hepatite B/complicações , Hepatite B/tratamento farmacológico , Vírus da Hepatite B/efeitos dos fármacos , Hepatite C/complicações , Humanos , MasculinoRESUMO
Hepatitis E is transmitted mainly by water or food, but in industrialized countries, all routes of transmission have not been identified. We describe possible zoonotic transmission of hepatitis E virus that involved direct contact between a pet pig and its owner.
Assuntos
Vírus da Hepatite E/isolamento & purificação , Hepatite E/transmissão , Doenças dos Suínos/transmissão , Zoonoses , Adulto , Animais , Animais Domésticos , Anticorpos Antivirais/sangue , Reservatórios de Doenças/veterinária , Reservatórios de Doenças/virologia , Amplificação de Genes , Genótipo , Hepatite E/veterinária , Hepatite E/virologia , Vírus da Hepatite E/classificação , Vírus da Hepatite E/imunologia , Humanos , Fígado/enzimologia , Fases de Leitura Aberta , Filogenia , RNA Viral/química , RNA Viral/genética , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Especificidade da Espécie , Suínos , Doenças dos Suínos/virologiaAssuntos
Antivirais/efeitos adversos , Hepatite C Crônica/tratamento farmacológico , Interferon-alfa/efeitos adversos , Doenças Pulmonares Intersticiais/induzido quimicamente , Ribavirina/efeitos adversos , Antivirais/uso terapêutico , Quimioterapia Combinada , Feminino , Humanos , Interferon alfa-2 , Interferon-alfa/uso terapêutico , Doenças Pulmonares Intersticiais/diagnóstico por imagem , Pessoa de Meia-Idade , Polietilenoglicóis , Proteínas Recombinantes , Recidiva , Ribavirina/uso terapêutico , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND/AIMS: Lymph nodes in the hepatoduodenal ligament seem to be a common ultrasonographic finding in patients with chronic hepatitis C. Lymphadenopathic enlargement is associated with the histological hepatic features reflecting the immunological response of the host, but the correlation between lymphadenopathy, liver histology and the cellular immunoreactivity of the host has never been studied. AIM: (1) To specify the prevalence of lymph nodes within the hepatoduodenal ligament; and (2) to investigate whether lymphadenopathies might reflect the immunological response of the host. METHODS: One hundred and eleven patients were enrolled in this study. Eleven chronic hepatitis B patients and 34 healthy volunteers served as controls. RESULTS: Lymph nodes were detectable in 90 out of the 104 chronic hepatitis C patients studied. After logistic regression, a high CD8 level and the absence of post hepatitis C cirrhosis were associated with lymph node enlargement. The total lymph node volume was correlated with transaminase levels, inflammatory activity, and stage of fibrosis. CONCLUSIONS: (1) The prevalence of lymph nodes within the hepatoduodenal ligament is high; (2) lymph node enlargement is correlated with the immunological cellular response of the host; and (3) the total lymph node volume is correlated with hepatic necroinflammatory markers and the stage of fibrosis.
