RESUMO
The National registry of patients with neuroendocrine tumors (NET) in Bulgaria was established in 2013 as a joint initiative of the Bulgarian Surgical Society and the Institute for Rare Diseases. The register aims to explore the epidemiology of NET in Bulgaria, as well as the different diagnostic and treatment approaches for the disease throughout the country. This the first of its kind retrospective study of NET in the country is covering the period January 2012 - January 2013. A total of 127 patients with NET were identified. At the time of the survey the average age of patients with NET was 58.61 ± 15.59 years. The data show almost equal distribution between the genders with a slight predominance of women. The largest relative part of NET is those of NET located in the gastrointestinal tract (54.10 ± 4.51%), followed by those located in the pancreas (12.30 ± 2.97%) and in the lungs (10.66 ± 2.79%). In 72.44 ± 3.96% of the patients a immunohistochemical diagnosis was performed. The study confirmed the leading role of the surgery method of the NET management. In 65.83 ± 4.33% of the patients a radical removal of the tumor was conducted, while the relative part of the undertaken partial resection was 7.50 ± 2.40%. A statistically significant association between the type of surgical treatment and during the follow-up of patients was found. An update of the information in the register will allow a more precise determining of the distribution and management of NET in Bulgaria.
Assuntos
Neoplasias Gastrointestinais/epidemiologia , Neoplasias Pulmonares/epidemiologia , Tumores Neuroendócrinos/epidemiologia , Neoplasias Pancreáticas/epidemiologia , Adulto , Idoso , Bulgária/epidemiologia , Feminino , Neoplasias Gastrointestinais/diagnóstico , Neoplasias Gastrointestinais/terapia , Trato Gastrointestinal/patologia , Humanos , Pulmão/patologia , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/terapia , Masculino , Pessoa de Meia-Idade , Tumores Neuroendócrinos/diagnóstico , Tumores Neuroendócrinos/terapia , Pâncreas/patologia , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/terapia , Projetos Piloto , Sistema de Registros , Estudos RetrospectivosRESUMO
Nine paranoic schizophrenia patients and nine controls participated in the study aimed at revealing differences in their ability to discover a pattern of auditory stimuli and to react to changes in environmental probability structure. Two kinds of auditory stimuli were used: high--1200 Hz (H) and low--800 Hz (L), both of 50 msec duration and 60 dB intensity. The experimental series were: series 1 (S1)--simple motor reaction to 50 L tones; series 2 (S2) and series 3 (S3) were identical--a cycle signal pattern (HHLHLL) of 102 tones. In S2 the instruction required choice motor reaction to L tone and in S3, also discovering the tone sequence and its verbal announcement. Patients discovered the stimulus pattern at the 28th and controls at the 30th signal. RT of patients in all series was longer than that of controls. Each of the factors "group" (controls/patients) and "experimental series" had a significant influence on RT. The possibility of interpreting these results as connected with an extrasensor mechanism dysfunction is discussed.
