RESUMO
We report a case of botfly myiasis presenting as an ankle cellulitis in a teenager returning from Guyana. Main clinical features and therapeutic approaches are described.
Assuntos
Mordeduras e Picadas de Insetos/diagnóstico , Miíase/diagnóstico , Adolescente , Animais , Antibacterianos/uso terapêutico , Argentina , Dípteros , França , Guiana , Humanos , Mordeduras e Picadas de Insetos/tratamento farmacológico , Larva/efeitos dos fármacos , Masculino , México , Miíase/tratamento farmacológico , Miíase/transmissão , ViagemRESUMO
Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder due to alpha-L-iduronidase deficiency. Its severe prognosis has been significantly improved by enzyme replacement therapy using recombinant human alpha-L-iduronidase (laronidase). We report the case of a boy who was diagnosed at 19 months of age with Hurler's disease, the most severe form of MPS I, and received thereafter a treatment by laronidase, resulting in clinical and biological improvement. The aim of this case report is to draw physicians' attention on the presenting signs of Hurler's disease, in order to enable an earlier diagnosis, increasing the treatment's benefits.
Assuntos
Iduronidase/uso terapêutico , Mucopolissacaridose I/tratamento farmacológico , Criança , Diagnóstico Diferencial , Seguimentos , Humanos , Lactente , Mucopolissacaridose I/diagnóstico , Resultado do TratamentoRESUMO
Long-term low dose azithromycin treatment in cystic fibrosis patients with chronic Pseudomonas aeruginosa infection is safe and reduces the decline in lung function, the number of acute exacerbations and improves nutritional status; underlying efficacy mechanisms are multiple and synergistic.
Assuntos
Antibacterianos/uso terapêutico , Azitromicina/uso terapêutico , Fibrose Cística/complicações , Infecções por Pseudomonas/tratamento farmacológico , Criança , Humanos , Infecções por Pseudomonas/etiologiaRESUMO
Acute arteriopathies are the etiological factor of 25% of all the cerebral arterial thrombosis cases in childhood; they give way to ischemic strokes which have specific clinical and radiological features; varicella is the etiologic factor in 60% of the cases; favorable outcome is the rule; physiopathology and treatment remain under discussion.