Green Synthesis and Evaluation of the Biological Activity of New Dihydropyridine Derivatives.

AIMS AND OBJECTIVE: This work used silica-coated magnetic nanoparticles functionalized by iminodiacetic acid-cupper (Fe3O4@SiO2/IDA-Cu) to perform one-pot multicomponent reactions involving (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione (curcumine), primary amines, and activated acetylenic compounds in an aqueous medium at room temperature and to produce 1,4- dihydropyridine-2,3-dicarboxylate in high yields. Further research on this area uses diphenylpicrylhydrazine (DPPH) radical trapping to investigate the antioxidant properties of some generated 6,6´- methylene bis-1,4-dihydropyridine-2,3-dicarboxylates. Scholarly research now underway concentrates on examining the antibacterial characteristics of chemical substances that have been produced. MATERIALS AND METHODS: The reagents or solvents that the research team utilized were of analytical quality, which means that their physical and chemical characteristics were unaltered. The Ft-IR spectra of the prepared nanocatalysts and the synthesized 6,6´-methylene bis-1,4-dihydropyridine-2,3-dicarboxylates in a KBr medium were recorded using a Shimadzu IR-460 spectrometer. In addition, a Bruker DRX-400 AVANCE spectrometer was used to get the 1H and 13C NMR spectra of the produced compounds. To get the spectrum of the compounds generated, the spectrometer was calibrated to 400 MHz, the solvent was CDCl3, and the internal standard was TMS. It should be mentioned that the mass spectra of the generated compounds, which have an ionization capability of 70 eV, were obtained using the Finnigan MAT 8430 spectrometer. Using spectroscopy investigation, including X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and vibrating sample magnetometer (VSM), the synthetic catalyst Fe3O4@SiO2@IDA-Cu was approved for construction. Finnigan-MAT 8430 spectrometer was used to generate mass spectra of the chemicals that were created. To determine which element was present in the compounds that were formed, the Heraeus CHN-O-Rapid analyzer was used. RESULTS: The current study focused on creating new 6,6´-methylene bis-1,4-dihydropyridine-2,3- dicarboxylates 4 by combining curcumine 1, primary amines 2, and activated acetylenic compounds 3 in three-component processes. The reactions were performed in a water-based solution at normal ambient temperature, using Fe3O4@SiO2@IDA-Cu as a nanocatalyst that may be used multiple times. The findings demonstrated that the synthesized compounds displayed a significant antioxidant potential in comparison to conventional antioxidants. Furthermore, the produced compounds were evaluated for their antibacterial efficacy against both gram-positive and gram-negative bacteria. CONCLUSION: In conclusion, the multicomponent reactions involving curcumin, primary amines, and activated acetylenic chemicals were investigated in a water-based setting at normal room temperature. The reactions were carried out using a new type of catalyst called Fe3O4@SiO2@IDA-Cu, which is an organometallic nanocatalyst. This led to the creation of new versions of 6,6´-methylene bis-1,4-dihydropyridine-2,3- dicarboxylates with antioxidants and antibacterial activity.

Antioxidant potential and essential oil properties of Hypericum perforatum L. assessed by application of selenite and nano-selenium.

It is necessary to develop a simple way to achieve food quality quantitatively. Nanotechnology is a key advanced technology enabling contribution, development, and sustainable impact on food, medicine, and agriculture. In terms of medicinal and therapeutic properties, Hypericum perforatum is an important species. For this study, a randomized complete block design with three replications was used in each experimental unit. The foliar application of selenite and nano-selenium (6, 8, 10, and 12 mg/l), control (distilled water), at the rosette stage and harvesting at 50% flowering stage has been applied as an alleviation strategy subjected to producing essential oils and antioxidant activity. Experimental results revealed that the selenite and nano selenium fertilizers had a significant effect on traits such as total weight of biomass, essential oil percentage, the content of hypericin and hyperforin, the selenium accumulation in the plant, relative leaf water content, chlorophylls, phenolic content, proline, catalase, peroxidase, malondialdehyde, and DPPH. The highest essential oil content was obtained from the control treatment when the accumulation of selenium was achieved with 12 mg/l nano-selenium. The maximum rate of hypericin was seen in the foliar application of 8 mg/l selenite whereas the maximum hyperforin was gained at 10 mg/l selenium. Conceding that the goal is to produce high hypericin/ hyperforin, and also the accumulation of selenium in the plant, treatments of 6 and 8 mg/l of selenite and nano-selenium could be applied. Consequently, an easy detection technique proposed herein can be successfully used in different ranges, including biology, medicine, and the food industry.

Biosynthesis of Cu/KF/Clinoptilolite@MWCNTs nanocomposite and its application as a recyclable nanocatalyst for the synthesis of new Schiff base of benzoxazine derivatives and reduction of organic pollutants.

In this work, we synthesized new Schiff base of benzoxazine derivatives in excellent yields using multicomponent reactions of phthalaldehyde or its derivatives, primary amines, isothiocyanate, 2,4-dihydroxyacetophenone, isopropenylacetylene and methyl or ethyl amine in the presence of catalytic amount of Cu/KF/CP@MWCNTs NCs in water at room temperature. Also, the catalytic activity of the green synthesized Cu/KF/CP@MWCNTs NCs was evaluated in the reduction in organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized NCs have very high and effective catalytic activity for organic pollutants within few seconds. As well the antioxidant activity of some synthesized benzoxazine was studied using trapping of radical by DPPH and ferric reduction activity potential (FRAP) experiment. The short time of reaction, high yields of product, easy separation of catalyst and products are some benefits of this procedure.