1.
Nat Struct Mol Biol
; 17(10): 1269-71, 2010 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20818392
RESUMO
The exon junction complex (EJC), which is deposited onto mRNAs as a consequence of splicing, is involved in multiple post-transcriptional events in metazoa. Here, using Drosophila melanogaster cells, we show that only some introns trigger EJC-dependent nonsense-mediated mRNA decay and that EJC association with particular spliced junctions depends on RNA cis-acting sequences. This study provides the first evidence to our knowledge that EJC deposition is not constitutive but instead is a regulated process.