RESUMO
Merkel cells (MCs) are well recognized in the basal layers of the skin and oral mucosa, but this paper describes for the first time the presence of MCs in the human oesophagus. These cells are not identified in neonatal oesophagus, but are seen singly and in clusters in adult specimens. Application of stereological techniques shows that MCs are more numerous in the mid-oesophageal region. Cells expressing established markers of MCs have also been demonstrated in two out of six primary small cell carcinomas of the oesophagus. Further investigation of the role of MCs in oesophageal innervation and epithelial biology will be of interest.
Assuntos
Carcinoma de Células Pequenas/patologia , Neoplasias Esofágicas/patologia , Esôfago/ultraestrutura , Células de Merkel/ultraestrutura , Adulto , Biomarcadores Tumorais/metabolismo , Carcinoma de Células Pequenas/metabolismo , Contagem de Células , Neoplasias Esofágicas/metabolismo , Humanos , Lactente , Proteínas de Filamentos Intermediários/metabolismo , Queratina-20 , Células de Merkel/metabolismo , Proteínas de Neoplasias/metabolismoRESUMO
Malignant mesothelioma (malignant adenomatoid tumour) of the tunica vaginalis testis is a very rare neoplasm with highly aggressive biological behaviour. Treatment is difficult, and widespread local invasion and/or metastatic disease at presentation are associated with a poor prognosis. In this case report we describe for the first time a patient who, despite presenting with locally advanced disease, remains well 10 years after diagnosis and treatment with radical orchidectomy and high dose radiotherapy.
Assuntos
Mesotelioma/patologia , Orquiectomia/métodos , Neoplasias Testiculares/patologia , Idoso , Terapia Combinada , Humanos , Masculino , Mesotelioma/radioterapia , Mesotelioma/cirurgia , Neoplasias Testiculares/radioterapia , Neoplasias Testiculares/cirurgiaRESUMO
Multiple renal capsular leiomyoma is an extremely rare tumour. We describe one such case which was managed by renal sparing surgery.
Assuntos
Neoplasias Renais/diagnóstico , Leiomiomatose/diagnóstico , Carcinoma de Células Renais/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias Renais/cirurgia , Leiomiomatose/cirurgia , Pessoa de Meia-IdadeRESUMO
Lipomatosis has not previously been reported in minor salivary glands. Its occurrence in the parotid gland is well recognized. We present the first reported case of lipomatosis of the minor salivary glands in the nasal cavity. We also review the tumours of the minor salivary glands, lipomas and lipomatosis of the parotid, and the few reported cases of lipomas of the sinonasal tract.
Assuntos
Lipomatose/diagnóstico , Neoplasias das Glândulas Salivares/diagnóstico , Glândulas Salivares Menores , Adulto , Feminino , Humanos , Lipomatose/patologia , Cavidade Nasal/diagnóstico por imagem , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/diagnóstico por imagem , Glândulas Salivares Menores/patologia , Tomografia Computadorizada por Raios XRESUMO
Canalicular adenoma is a recently classified uncommon salivary gland neoplasm. This biologically benign growth tends to be multifocal and occurs most often in the upper lips of elderly people. Histologically and clinically it differs from the basal cell adenoma, for which it may be mistaken, in a number of ways. Its clinical importance lies in the fact that it may be confused with malignancy. Little information is available regarding the recurrence and long-term follow-up of these tumours, and where available it covers only relatively short periods. We report the recurrence of a canalicular adenoma after an 11.2 year disease-free period.
