1.
Bioorg Med Chem Lett
; 15(22): 4915-8, 2005 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16165350
RESUMO
The synthesis of potent 4-aryl methoxypiperidinol inhibitors of the dopamine transporter is described. Symmetrical para substituents of the benzene rings are important for high potency in binding to the dopamine transporter. 4-[Bis(4-fluorophenyl) methoxy]-1-methylpiperidine has an IC50 of 22.1+/-5.73 nM and increases locomotor activity in mice.