1.
Bioorg Med Chem Lett
; 22(4): 1770-3, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22264480
RESUMO
A group of novel synthetic indoloisoquinolines was prepared and its potential as a novel series of small-molecule anti-malarial leads was assessed. The structure-activity relationship on variation of three distinct regions of chemical space was investigated. A lead compound was generated with an activity close to that observed for a known anti-malarial natural product, dihydrousambarensine, that shares the indoloisoquinoline template structure.