The role of communication technology across the life course: A field guide to social support in East York.

This paper builds on a body of work over the decades that examines how East Yorkers give and receive support. We go beyond the earlier work taking into consideration communication technologies and how they play a role in the ways people exchange social support across the life course. We draw on 101 in-depth interviews conducted in 2013-2014 to shed light on the support networks of a sample of East York residents and discern the role of communication technologies in the exchange of different types of social support across age groups. Our findings show that not much has changed since the 1960s in terms of the social ties that our sample of East Yorkers have, and the types of support mobilized via social networks: companionship, small and large services, emotional aid, and financial support. What has changed is how communication technologies interweave in complex ways with different types of social ties (partners, siblings, friends, etc.) to mobilize social support. We found that communication technologies helped siblings and extended kin to increase the frequency of interaction and help exchange support at a distance. Communication technologies helped solidify friendship ties by providing a continuous flow of interaction. We draw implications for theories of social support and for social policy associated with interventions aimed at helping vulnerable groups cope in hard times such as the COVID-19 pandemic.

Visual rating and volumetric measurement of medial temporal atrophy in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort: baseline diagnosis and the prediction of MCI outcome.

OBJECTIVE: This study aims to determine the clinical utility of visual ratings and volumetric measurements of medial temporal atrophy among subjects from the Alzheimer's Disease Neurorimaging Initiative (ADNI) cohort. METHODS: A sample of 189 subjects from the ADNI, Phase 1 (ADNI-1), was chosen as follows: 49 cognitively normal (CN), 89 with mild cognitive impairment (MCI), and 50 with Alzheimer's disease (AD). Structural MRI images were downloaded from the ADNI website, and a visual rating system (VRS) was used to obtain semi-quantitative ratings of the hippocampus (HPC) and entorhinal cortex (ERC). VRS ratings and FreeSurfer measures of the HPC and ERC were used to predict (i) baseline diagnosis and (ii) progression to AD among subjects with MCI at baseline. RESULTS: VRS and FreeSurfer measures of ERC were equivalent in classifying subjects at baseline, but FreeSurfer measures of HPC were superior to VRS measures for classifying CN versus MCI subjects. VRS and FreeSurfer measures of both HPC and ERC were significant predictors of progression from MCI to AD. However, VRS ratings of ERC were superior to other MRI measures. MCI subjects with minimal ERC atrophy by VRS had a threefold lower progression rate to AD at 3.2 years compared with those with mild, moderate, or severe atrophy (23% vs 63%, 69%, and 87%, respectively). CONCLUSIONS: Visual ratings of HPC and ERC provide useful information to a physician in a clinical setting. Visual ratings of ERC may be especially useful in following patients with MCI.