1.
Bioorg Med Chem Lett
; 15(2): 435-8, 2005 Jan 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15603968
RESUMO
A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described.
Assuntos
Hidrocarbonetos Aromáticos/química , Imidazóis/farmacologia , Antagonistas do Receptor Purinérgico P2 , Animais , Linhagem Celular , Cricetinae , Imidazóis/síntese química , Imidazolinas/síntese química , Imidazolinas/farmacologia , Concentração Inibidora 50 , Receptores Purinérgicos P2X7 , Relação Estrutura-Atividade
2.
Nature
; 420(6916): 703-6, 2002 Dec 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12478301
RESUMO
The Alliance for Cellular Signaling is a large-scale collaboration designed to answer global questions about signalling networks. Pathways will be studied intensively in two cells--B lymphocytes (the cells of the immune system) and cardiac myocytes--to facilitate quantitative modelling. One goal is to catalyse complementary research in individual laboratories; to facilitate this, all alliance data are freely available for use by the entire research community.
