May Thurner syndrome: Sixty years later.

May-Thurner syndrome (MTS) was described sixty years ago. Once ignored for several years, it is currently a recognized pathology in the vascular surgery community; but not long ago due to several factors, it was underdiagnosed and sub-optimally treated. In the last 20 years, with renewed interest in venous pathology, technical imaging advances and the recent interventional procedures, it has become a better known disease. On the other hand, nowadays the easiness in diagnosis and treatment of the syndrome has lead to overtreatment of such patients. In this article, we do a historical review and describe the significant advances and current management of May-Thurner syndrome.

Cardiac senile amyloidosis: a review / Amiloidosis cardíaca senil: una revisión

Abstract: Cardiac senile amyloidosis related to wild-type transthyretin is not so infrequent as previously thought, several cases of heart failure with preserved ejection fraction might be related to this infiltrative disorder. Usually it is underdiagnosed because of the requirement of histological diagnosis and reluctance to do biopsy in this frail elderly population. Noninvasive diagnostic methods available will increase diagnosis of cardiac transthyretin amyloidosis (ATTR), and the direct consequence will be more investigations and clinical trials on diagnosis and therapeutics of ATTR.

Resumen: La amiloidosis cardiaca senil relacionada con transtiretina tipo salvaje no es tan infrecuente como se ha pensado previamente, varios casos de insuficiencia cardiaca con fracción de expulsión preservada pueden estar relacionadas con esta enfermedad infiltrativa. Habitualmente es sub-diagnosticada debido a que se requiere estudio histológico y existe reticencia a realizar biopsias en esta población de pacientes seniles por su fragilidad. Nuevos métodos diagnósticos no invasivos incrementarán el diagnóstico de amiloidosis cardiaca por transtiretina, y la consecuencia directa será una mayor investigación y ensayos clínicos para su diagnóstico y tratamiento.