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1.
Vet J ; 204(2): 223-5, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25956344

RESUMO

Oral squamous cell carcinomas (OSCCs) are common neoplasms of dogs and are of unknown cause. Whereas papillomaviruses (PVs) are an established cause of human OSCCs, few studies have investigated canine OSCCs for a PV aetiology. In humans, a PV aetiology can be determined by detecting PV DNA and PV-induced increased p16(CDKN2A) protein (p16) within the OSCC. In this study, PCR, using four different primer sets and p16 immunohistochemistry, was used to evaluate 28 canine OSCCs for a possible PV aetiology. None of the primers amplified PV DNA from any of the OSCCs although four neoplasms contained intense p16 immunostaining. Intense p16 immunostaining would indicate a PV aetiology in a human OSCC but the absence of PV DNA suggests that the increase in p16 was not due to PV infection. Overall the results indicated that PVs are not a significant cause of canine OSCCs.


Assuntos
Carcinoma de Células Escamosas/veterinária , Doenças do Cão/virologia , Lambdapapillomavirus/isolamento & purificação , Neoplasias Bucais/veterinária , Animais , Carcinoma de Células Escamosas/virologia , Cães , Neoplasias Bucais/virologia
2.
J Vet Diagn Invest ; 27(2): 221-5, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25613043

RESUMO

Papillomaviruses (PVs) are well recognized to cause human oral squamous cell carcinomas (SCCs). However, there is currently little evidence that PVs similarly cause oral cancer in dogs. In the present case, a dog developed an invasive SCC and multiple in situ carcinomas within the mouth. Cell changes consistent with PV infection were prominent within the neoplasms and the surrounding gingiva. Immunohistochemical staining revealed PV antigens and intense p16(CDKN2A) protein (p16) immunostaining within the invasive SCC. Papillomaviral DNA sequences were amplified from the invasive and in situ carcinomas. Sequencing revealed that the DNA was from a novel PV that appears most closely related to canine PV-2 and -7. To the authors' knowledge, multiple carcinomas have not been previously reported in the mouth of a dog. Additionally, the current study describes PV cytopathology in a canine oral SCC. Whether the PV infection influenced neoplasm development cannot be definitively determined in this case. However, the presence of p16 immunostaining and the development of multiple oral carcinomas support a role of the PV in tumorigenesis in this dog.


Assuntos
Carcinoma de Células Escamosas/veterinária , Doenças do Cão/diagnóstico , Neoplasias Bucais/veterinária , Papillomaviridae/isolamento & purificação , Animais , Antígenos Virais/análise , Carcinoma de Células Escamosas/diagnóstico , Inibidor p16 de Quinase Dependente de Ciclina/imunologia , DNA Viral/análise , Diagnóstico Diferencial , Doenças do Cão/virologia , Cães , Imuno-Histoquímica/veterinária , Masculino , Neoplasias Bucais/diagnóstico , Papillomaviridae/genética
3.
J Feline Med Surg ; 12(2): 144-50, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19692276

RESUMO

A 1-year-old oriental cat was presented with a peracute onset of tetraparesis and vocalisation. Clinical findings were suggestive of multi-site thromboembolic disease, and this was confirmed on post-mortem examination. An echocardiogram showed severe restrictive cardiomyopathy and spontaneous echogenic contrast. To the author's knowledge, this is the first reported case of tetraparesis secondary to cardiogenic arterial thromboembolic disease. Thromboembolic disease should be included as a differential diagnosis for any cat presented with a peracute onset of paresis or paralysis, even if there is no history of cardiac disease.


Assuntos
Doenças do Gato/diagnóstico , Cardiopatias/veterinária , Coxeadura Animal/etiologia , Tromboembolia/veterinária , Animais , Gatos , Evolução Fatal , Feminino , Cardiopatias/complicações , Cardiopatias/diagnóstico , Tromboembolia/complicações , Tromboembolia/diagnóstico
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