The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues.

An important feature of the functioning of the organs and tissues of the oral cavity is the fact that all processes that take place in it are carried out in the constant presence of various microorganisms that cause the development of pathological processes in the body or are associated with them. In the pathogenesis of chronic generalized periodontitis, dental plaque penetrates the bottom of the gingival sulcus, penetrating under the epithelium into the stroma of the connective tissue, causing its inflammation. Bacteria produce a number of toxic substances that have a toxic effect on surrounding tissues. Most bacteria produce chain fatty acids that inhibit chemotaxis of leukocytes and phagocytes. Anaerobes and spirochetes secrete a number of substances (propionic acid and indole) that are extremely toxic to most tissues. Inflammation in the periodontal tissues is caused by the microbiota of the dental plaque biofilm. As periodontitis develops, an increase in the number of P. gingivalis, P. intermedia and T. forsythia was found in it, more than 100 times. Therefore, the given data prove that in the development and course of the inflammatory process in the periodontal tissues, complex dysbiotic and tissue-cellular interactions are involved, the dynamic balance of which depends on its outcome.

FEATURES OF THE VARIATIVE MORPHOLOGY OF THE MANDIBULAR SECOND MOLAR USING CONE-BEAM COMPUTED TOMOGRAPHY IMAGING.

OBJECTIVE: The aim: To characterize the variations in the anatomical structure of the second lower molar. PATIENTS AND METHODS: Materials and methods: In order to determine the topography of the roots and root canals of the mandibular second molar, modern imaging methods were used: orthopan¬tomography and cone-beam computed tomography. RESULTS: Case report: During the analysis of the orthopantomogram of the patient, the three-root morphology of the root system of 37 teeth was revealed. That is, three roots were clearly visualized. After detecting an atypical shape of the root system of the mandibular second molar in the panoramic image, the patient was offered to perform cone-beam computed tomography (CPCT) for diagnostic purposes. Analysis by cone-beam computed tomography showed the presence of four mature roots of normal length, which were arranged in the shape of a diamond. CONCLUSION: Conclusions: The four-root configuration is considered a rare form for mandibular molars, but it should be considered in endodontic interventions and, if possible, in the planning of such interventions, use cone-beam computed tomography.

MORPHOLOGICAL CHANGES OF PERIODONTAL COMPONENTS UNDER EXPERIMENTAL LIPOPOLYSACCHARIDE PERIODONTITIS COMBINED WITH HYPERTHYROIDISM.

OBJECTIVE: The aim: Investigate structural changes in the tissues of the periodontal complex under the condition of experimental lipopolysaccharide periodontitis combined with hyper¬thyroidism. PATIENTS AND METHODS: Materials and methods: The studies were performed on adult white male rats, which simulated periodontitis combined with hyperthyroidism. Periodontal tissues were subjected to morphological examination on the 22nd day of the experiment. Collection of material for microscopic examinations was performed according to the generally accepted method; histological specimens were studied using a light optical microscope. RESULTS: Results: Morphological studies of the components of the periodontal complex of experimental animals with experimental periodontitis established the reorganization of its structural elements. Damage to the epithelium in the area of attachment of the circular ligament and erosive-ulcerative changes of the gums led to a deepening of the gingival sulcus with the formation of a deep periodontal pocket. Intense hyperkeratosis was observed in the area of the bottom of the periodontal pocket. In the own plate of the mucous membrane of the gums - significant edema, collagen fibers were disorganized, defragmented. There were pronounced destructive-degenerative and inflammatory changes of the epithelial and own plates of all areas of the gums and periodontium, damage to the nuclei and cytoplasm of keratinocytes, fibroblasts, and leukocytes. CONCLUSION: Conclusions: Experimental periodontitis combined with hyperthyroidism is accompanied by pronounced signs of destructive and inflammatory changes in the soft and dense tissues of the periodontal complex, as well as disruption of stromal-vascular interactions, which progress from reversible to irreversible disruption of periodontal connective tissue.

COMPARATIVE ANALYSIS OF ENDURANCE CEMENTS FOR THE FIXATION OF NON-REMOVABLE ORTHOPEDIC CONSTRUCTIONS UNDER THE ACTION OF CYCLIC COMPRESSION.

OBJECTIVE: The aim: To conduct studies of the physical and mechanical properties of cements for fixation, namely the duration of cement samples under cyclic compression. PATIENTS AND METHODS: Materials and methods: We have conducted a study of 6 cements for permanent fixation of fixed structures of dentures. To study the duration of cements under cyclic compression, a special stand was used, which allows testing samples for cyclic compression with a load frequency of 5.4 Hz or 324 cycles per minute and an increase in compression in a cycle from 10 to 100 kg/s. RESULTS: Results: Comparative analysis of the mechanical properties in compression of dental cements for permanent fixation showed that the obtained deformation curves differ significantly in each of the cement samples used in the study. CONCLUSION: Conclusions: The results of the study of the physical and mechanical properties of cements indicate that the most optimal complex of properties is possessed by the zincphosphate cement Unitsem and glass ionomer cements Cemion and Fuji I. This is most clearly confirmed when studying the duration of cement samples under cyclic compression, which simulates a real situation.

Biological compatibility of metal structures of dentures made from multiple melted alloys.

The issue of reuse of metal alloys in dentistry raises debatable questions about their impact on the human body. AIM: The aim of the study was the evaluation of the biocompatibility of metal structures of dentures made from cobalt-chromium and nickelchromium alloys Remanium GM 700 and Remanium CSe after repeated vacuum remelting. MATERIALS AND METHODS: Clinical study and treatment with fixed prostheses based on Remanium GM 700 and Remanium CSe were performed among 120 patients aged 25-60 years. The biocompatibility of the above-mentioned denture designs with oral tissues was studied. RESULTS: Prostheses made from Remanium GM 700 and Remanium CSe alloys are biologically indifferent, which is confirmed by the indicators of alkaline and acid phosphatase activity within the physiological norm. Regardless of the number of remelts, these alloys do not cause dysbacteriosis. The obtained results do not depend on the terms of observation, which indicates the safe use of remolten alloys for dental prosthetics. CONCLUSIONS: The investigated alloys are biocompatible and can be used for the manufacture of solid structures of dentures.

DYNAMICS OF CHANGES OF C-REACTIVE PROTEIN LEVEL IN BLOOD SERUM IN THE DEVELOPMENT AND COURSE OF EXPERIMENTAL PERIODONTITIS AND THEIR CORRECTION BY FLAVONOL.

OBJECTIVE: The aim: To study the value of C-reactive protein in the experimental animals blood serum with bacterial-immune periodontitis and its correction with quercetin. PATIENTS AND METHODS: Materials and methods: Modeling of periodontitis was performed by the following method: after thiopental anesthesia (at a dose of 40 mg / kg intramuscularly) rats were fixed. A subcostal injection of 0.01 ml of egg protein with cultures of Streptococcus hemolytic and Staphylococcus aureus at a dose of 4 CFU was performed in the area of periodontal tissues of the lower incisor as an initiating inflammatory factor. To enhance the immune process, a complete Freund's adjuvant was introduced into the animal's hind limb at the same time. RESULTS: Results: Analysis of the results of the study of the content of C-reactive protein in the blood serum of animals with experimental bacteria and immune periodontitis, receiving injections of quercetin, showed a significant decrease by 1.31 times, compared with animals with this simulated pathology on the 14th day of the experiment without the use of flavonol. When comparing this indicator on the 14th day of development of experimental periodontitis with correction, it was found that it remained slightly higher than the indicators of the intact group of rats. CONCLUSION: Conclusions: The level of C-reactive protein in the blood serum of experimental animals is an important indicator of the immune-inflammatory response, which increases its activation of the inflammatory system. The administration of flavonoid quercetin for 7 days helps to reduce the level of C-reactive protein in the blood serum of animals with experimental bacterial and immune periodontitis.

CYTOKINOGENESIS DISORDERS IN MECHANISMS OF THE EXPERIMENTAL PERODONTITIS DEVELOPMENT AND THEIR CORRECTION BY FLAVONOL.

OBJECTIVE: The aim: Evaluation of changes in proinflammatory and anti-inflammatory units of the cytokine profile in the mechanisms of development of experimental bacterial-immune periodontitis and elucidation of the effect of flavonol quercetin on its parameters. PATIENTS AND METHODS: Materials and methods: Experimental periodontitis was caused by introducing into the tissues of the periodontal complex a mixture of microorganisms diluted with egg protein. In order to enhance the immune response, a complete Freund's adjuvant was injected into the rat's paw at the same time. For correction, intramuscular injections of water-soluble quercetin at a dose of 100 mg / kg body weight were performed for 7 days (7th to 14th day). RESULTS: Results: The use of flavonol quercetin led to a decrease in the serum content of experimental animals with pro-inflammatory cytokines. With regard to anti-inflammatory cytokines, their content in the blood of animals during the development of this simulated inflammatory process changed in the opposite direction. Quercetin effectively eliminated the imbalance of the immune system and increased the level of IL-10 and IL-4 in the serum. After injections of quercetin, the relation of pro- and anti-inflammatory cytokines in the serum of animals on 14th day of the study was reduced compared to their content in rats that did not receive correction. CONCLUSION: Conclusions: The formation and course of experimental bacterial-immune periodontitis is accompanied by a complex of pathological changes in immunocytokinogenesis, which is manifested by a progressive increase in serum concentrations of proinflammatory cytokines and a decrease in anti-inflammatory cytokines. Flavonol quercetin reduces the concentration of pro-inflammatory and increases the content of anti-inflammatory cytokines.

ANALYSIS OF THE ADVISABILITY OF USING DIFFERENT TYPES OF BASE PLASTICS BY STUDYING THE NEEDS OF THE POPULATION IN REMOVABLE PROSTHESIS.

OBJECTIVE: The aim: To determine the needs of the population of the Ternopil region in prosthetics with removable orthopedic dentures and to study the physical and technological properties of different types of base plastics. PATIENTS AND METHODS: Materials and methods: The needs of Ternopil and Ternopil region population in removable prosthetics were studied on the basis of consolidated annual reports of city and district dental clinics of Ternopil region. Base dental plastics «Ftoraks¼ (Stoma, Ukraine) and «Villacryl H Plus¼ (Zermapol, Poland) were used to study the physical and mechanical properties (deformations during compression and tension). RESULTS: Results: As a result of our research, we found that the need of the Ternopil region population for removable prosthetics is quite high. When analyzing the choice of designs of removable laminar prostheses, it was found that 64.99 ± 0.14% of patients required the manufacture of partial removable dentures, and 35.01 ± 0.18% - complete removable dentures. A significant difference was found in the physical and technical characteristics of the samples of the studied plastics, which were polymerized by various methods. CONCLUSION: Conclusions: Dental base plastic «Villacryl H Plus¼, which was packaged and polymerized by casting, has significantly higher physical and mechanical properties than dental base plastic «Ftoraks¼.

CHARACTERISTICS OF METAL ALLOYS PROPERTIES FOR DENTAL CASTING AFTER THEIR REPEATED REMELTING.

OBJECTIVE: The aim: To study clinical and experimental substantiation of the possibility of using cobalt-chromium and nickel-chromium alloys after repeated remelting for non-removable one-piece prosthetics. PATIENTS AND METHODS: Materials and methods: Experimental studies of Remanium GM 700 and Remanium CSe dental alloys have been carried out. To study the physical and mechanical properties of alloys, samples were obtained by sequential six-fold remelting in a Tiegelschleuder TS casting dental unit manufactured by Degussa. All samples were subjected to chemical analysis and metallographic studies by methods generally known in metallurgy, which included studies of microhardness, elasticity, tensile deformation, bending deformation and alloy structure after repeated remelting. RESULTS: Results: Thus, the obtained results of the chemical, physicomechanical and structural properties of the remelts indicate that the Remanium GM 700 and Remanium СSe alloys can be reused many times for the manufacture of one-piece orthopedic structures in that they are identical with certified alloys. CONCLUSION: Conclusions: In terms of structure, qualitative and quantitative composition of elements, physical and technological properties, the Remanium GM 700 and Remanium CSe alloys have been repeatedly remelted meet the requirements of materials used in biologically active environments of the patient's body. High-quality and cost-effective remelted multiple times Remanium GM 700 and Remanium CSe alloys can be recommended for use in practical prosthetic dentistry six times.

COMPARATIVE EVALUATION OF HISTOTOXICITY INDICATORS OF METAL ALLOYS FOR THE MANUFACTURE OF METAL CERAMIC DENTAL CONSTRUCTIONS.

OBJECTIVE: The aim: To carry out a comparative assessment of metal alloys for the manufacture of metal-ceramic constructions of dentures by determining the indicator of their histotoxicity. PATIENTS AND METHODS: Materials and methods: To identify the effect of metal alloys on cobalt and nickel bases on the tissue of organism, we carried out an experimental-morphological study of standard samples of metal alloys "Shot-alloy", "Remanium-2000", "Cerium", "Dent-NCB", "Cellite-N". RESULTS: Results: A careful histological analysis of the capsules formed around the metal alloy samples during two periods of the experiment showed that the healing time of the subcutaneous tissue was not the same. The most complete healing, that is, the formation of mature fibrous connective tissue, occurred during the implantation of the cobaltbased alloy "Remanium-2000" and the capsule formed at the end of the experiment around the implanted sample from the "Shot-alloy" alloy, and during the implantation of the "Cerium" alloy, healing the wound surface and the formation of a connective tissue capsule occurs fully than in previous cases. CONCLUSION: Conclusions: The analysis of the performed experiment testifies in favor of the point of view that the speed and quality of healing of damaged subcutaneous tissue upon the introduction of implanted research alloys depend largely on the individual chemical components that make up the alloys, or on their combination.

Comparative assessment of the state of bone resorption in patients with chronic generalized periodontitis according to orthopantomogram and cone-beam computed tomography.

AIM: The aim of the study was to assess bone resorption in patients with chronic generalized periodontitis according to orthopantomogram (OP) and cone-beam computed tomography (CBCT) and substantiate which of these methods is the most appropriate for use. MATERIALS AND METHODS: In order to compare the objectivity of the results of examining the periodontal bone tissue by the above methods (panoramic radiography and computed tomography), we analyzed 26 panoramic radiographs and computed tomograms of the same patients, performed on a PICASSO (3D) computed tomograph by «Vatech¼. RESULTS: Comparison of CBCT and OP data in patients with periodontal tissue disease showed a significant difference between the indicators of bone tissue resorption in the mesiodistal direction, and revealed that the volumetric image is significantly objective X-ray picture in periodontal diseases by identifying the state (resorption) of the vestibular and oral cortical plates in any section dentition. At the same time, only according to CBCT data, an objective assessment of bone resorption in the vestibulo-oral direction is likely. CONCLUSIONS: Mesiodistal CT and orthopantomographic data do not match well enough. They allow with high accuracy to identify areas of resorption only from the medial and distal sides. However, the vestibulooral CT projection indicates the bias of a two-dimensional image for obtaining an accurate X-ray picture of the state of the alveolar bone and a complete assessment of bone resorption.

EPIDEMIOLOGICAL INDICATORS OF DENTAL MORBIDITY OF CHILDREN AS AN INDICATOR OF ADVERSE ENVIRONMENTAL INFLUENCE.

OBJECTIVE: The aim: Is to study the ecological and hygienic situation in the living area of 6-year-old children in terms of drinking water (micro- and macroelements), to identify its relationship with the state of mineral metabolism in children's mouths, prevalence and intensity of temporary and permanent caries. PATIENTS AND METHODS: Materials and methods:Clinical and laboratory studies were to study the objective condition of the teeth -intensity of dental caries according to the recommendations of the WHO and the method of T.F. Vinogradova. The hygienic condition of the oral cavity was determined by the indices Silness-Loe, Stallard. RESULTS: Results: The results of our studies have shown that the proposed therapeutic and prophylactic complex, which includes drugs of endogenous (Vitafluor) and exogenous use (osteovitis, deep fluoridation, toothpastes "Splat junior" and "Lacalut fluor"), improves the hygienic state of the oral cavity, increases mineralizing the potential of the oral fluid and, as a result, helps to reduce the intensity of dental caries in children. CONCLUSION: Conclusions: The data obtained indicated a high caries prophylactic efficacy of the proposed therapeutic and prophylactic complex for 6-year-old children living in the zone of hypophtorosis.

MINERALIZATION OF TEETH ENAMEL AFTER ERUPTION.

OBJECTIVE: The aim: The paper was aimed at the study of the processes of mineralization of the enamel of the permanent tooth after its eruption. PATIENTS AND METHODS: Materials and methods: To study the structure of the enamel of permanent teeth has been carried out using light and electron microscopy. The study of the process of the development of the primordia of the permanent teeth involved 10 culled puppies of 30-40 days of age. Microscopic, electron microscopic, immunohistochemical methods of research have been used to study the processes of histogenesis. RESULTS: Results: The studies show that in the postnatal period, the formation of the crown, externally covered with cuticular epithelium, marks the formation of the primordium of the permanent tooth at the follicle stage. After eruption of a tooth, different parts of its crown have three individual structural and functional barriers to enamel biomineralization. The first one is provided by the cuticular epithelium of the pitted areas of the crown, which ensures filtering of the salivary fluid from the protein deposit in the form of a pellicle. The second barrier is defined on the lateral and cuspidate surfaces of the enamel, where the cuticle is erased or poorly expressed. The third structural and functional barrier of enamel biomineralization is located in the cervical portion of teeth of different classes. CONCLUSION: Conclusions: Different areas of the enamel in the tooth crown have specific filtration barriers, which can be distinguished as follows: pit-and-fissure-and-groove, cuspidateand-approximal, and cervical barriers. The cuticle is poorly expressed or totally absent on the cusps of the tooth crowns in contrast to pitted areas.

WEAR RESISTANCE OF DENTAL MATERIALS WHICH ARE USED FOR ANTERIOR TEETH RESTORATIONS.

OBJECTIVE: The aim of this study was to compare the wear resistance of such restorative materials as composite resin, feldspathic ceramic, leucite glass ceramic with intact enamel and to draw an analogy with some similar researches. PATIENTS AND METHODS: Materials and methods: In this research 20 extracted human teeth (maxillary incisors) without fillings and carious cavities were used as samples. All samples were disinfected and stored in saline in order to prevent dehydration. Teeth roots were cut off for the measure of fixation on an organic glass plate using chemically polymerizable resin. If necessary, the teeth were also cut on their lateral sides in order to give them equal size. The samples were placed in a frame-holder, located on the lever of the machine MI-2, which determines abrasion resistance under slipping. RESULTS: Results: The research has revealed that the average wear resistance of natural teeth was 122,67±4.9 J/mm3 (Tab 1). The archived result overcomes dental composite resin twice more (62.8±1.21 J/mm3), feldspathic ceramic 6.5 times more (16.32±1.2 J/mm3) and leucite ceramic over the half (73.79±3.12 J/mm3). CONCLUSION: Conclusion: Thus, according to this performed research and the analysis of the relative literature sources it can be stated that dental composite resin and leucite ceramics may be proposed as the materials of choice for anterior restoration of teeth. They have shown the good wear resistance and tolerance to antagonizing natural teeth.

The intensity of chronic catarrhal gingivitis in children depending on the age.

OBJECTIVE: The aim: To determine the degree of severity of the inflammatory process in periodontal tissues of children living in different ecological conditions. PATIENTS AND METHODS: Materials and methods: With the purpose of estimation of the condition of periodontal tissues the epidemiology examination of 642 children that live on territory with the high level of pollution and natural deficit of iodine and fluorine was conducted. RESULTS: Results: The study found that the increase of age of examined children causes the decrease of percentage of easy degree of severity of chronic catarrhal gingivitis, giving way to the advanced forms of the disease, and this process was more pronounced in children living in ecologically polluted region. In children-inhabitants of ecologically clean region easy degree of severity of chronic catarrhal gingivitis met more often than their peers living in environmentally polluted region. At the same time, average and heavy degree of severity of chronic catarrhal gingivitis in children living in ecologically contaminated region met more often than their peers, inhabitants of ecologically clean region. CONCLUSION: Conclusions. It was found that with increasing age of the examined children decreases the percentage of chronic catarrhal gingivitis of moderate severity.

Features of the course of enamel biomineralization processes in various anatomical areas of the tooth.

OBJECTIVE: The aim: To establish the features of the structural organization of enamel in various anatomical areas of the tooth and determine their influence on the characteristics of the course of biomineralization processes. PATIENTS AND METHODS: Materials and methods: The study of the structural features of enamel and dentin was performed on thin sections of various groups of teeth. Then morphological, histochemical and electron microscopic examination methods were used. RESULTS: Results: The study found that there are three structural and functional barriers to biomineralization of enamel, which are located in different anatomical areas of the tooth crown. Each of them has both general and specific features. Enamel biomineralization is a continuous process of exchange of calcium ions, donor of which is brushite. The stepwise process of biomineralization turns the latter into calcium octaphosphate, which then turns into hydroxyapatite. The latter, when destroyed by carbon dioxide, forms carboxyapatite. CONCLUSION: Conclusions: In the result of conducted study was established peculiarities of enamel mineralization processes in different anatomical parts of tooth.

DENTAL CROWN BIOMINERALIZATION DURING ITS HISTOGENESIS.

OBJECTIVE: The aim: Thepaper wasaimedat thestudyof thebiomineralization processesofa permanentdental crown in thepostnatal period of histogenesis. PATIENTS AND METHODS: Materials and methods: The study involved 30 culled puppies aged 30-40 days. To study the histogenesis of the germs of the permanent tooth from the cuticular epithelium in the postnatal period microscopic, electron microscopic, immunohistochemical methods of study have been used. RESULTS: Results: The studies show that in the postnatal period, the maturation of the germ of a permanent tooth starts with the synthesis of cells of the cuticular epithelium of the organic stroma, capable of subsequent mineralization. Differentiation of the proameloblasts, located on the surface of the dental papillary mesenchyma, at the early stages of histogenesis, is strongly associated with the appearance of a specific protein taftelin. Origination of secretory ameloblasts, which produce the protein enamelin, triggers the process of secondary biomineralization of the enamel. The terminal processes of the secretory ameloblasts produce the protein in the form of layers that overlap each other at a certain angle. Such layering of the structures of enamel and dentin contributes to the S-shaped maturation of the hard tooth tissues, strengthening them considerably. At the follicle stage, maturation of the dental crown, coated with cuticular epithelium, occurs. Invaginations of the cuticular epithelium form a characteristic topography of the dental crown, and enamel projections are further formed by the ameloblasts. Epitheliocytes of the inner layer of the enamel organ have desmosomal connections that allow the filtration of the salivary fluid at the stage of the enamel trophism. CONCLUSION: Conclusions: The findings of the study suggest that, normally, due to the cuticular epithelium, filtration of the salivary fluid occurs with protein deposition on it and subsequent infiltration of the calcium salts into the subjacent enamel.

Effects of quercetin on antioxidant potential in the experimental periodontitis development.

The results of experimental research of antioxidant system are presented in this article. Superoxide dismutase activity, catalase, and ceruloplasmin have been determined on the 7th and 14th days of experimental periodontitis development both without correction and with the injection of a water-soluble quercetin drug (corvitin). Hence, there was a decrease in superoxide dismutase activity, intensive increase in catalase activity, and ceruloplasmin maintenance in the blood serum during acute period of inflammatory process. The usage of flavonoid for 7  days resulted in stabilization of radical oxidation due to reduction of superoxide dismutase activity, maintenance at the high-level catalase activity, and ceruloplasmin concentration in the rat's blood plasma with experimental bacterial-immune periodontitis.

Sex differences of odontometrical indexes crowns of molars.

Modern reconstructive methods of dentistry (stopping, restoration, and prosthetics with different types of orthopedic constructions) require detailed examination of the anatomical structure of the teeth crowns, especially examination of the knowledge about the relief of masticatory surface. That is why, we conducted a detailed examination of the features of odontoglyphics of molars, according to the sex and determination the odontometrical teeth indices of the citizens of Ternopil region. To achieve the goals, we use the following research methods, such as odontological, odontometrical, and statistical. According to the odontometrical indices of the sizes of the crowns of the molars, women's processes of reduction are reflected more than men's. Sex differences of the crown sizes are specially defined on the second upper and second lower molars. In the result of the conducted researches, it was found and theoretically confirmed racial identity of Ternopil and Ternopil region citizens, and it was given the characteristics of the differences of odontometrical indices of molar crowns of males and females. The lore of these characteristics plays a great role in the clinic of prosthetic dentistry.

Oxidative modification of proteins in the process of experimental periodontitis development.

The article reveals patterns of changes in the parameters of oxidative modification of proteins for different periods of the inflammatory process in periodontal tissues during periodontitis. Biochemical researches of phenylhydrazones, aldehyde-, and ketone derivatives of neutral and basic proteins were determined in the blood of white rats on the 7th, 14th, and 30th days of the experimental periodontitis development, as well as in intact animals. The method for determination of the oxidative modification of proteins was based on the interaction of oxidized amino acid residues with 2,4-dinitrophenylhydrazine to form 2,4-dinitrophenylhydrazones. At the early stage of experimental periodontitis development, i.e., on the 7th day, an increase in the products of oxidative modification of proteins of basic and neutral nature was observed in the blood serum, but later, on the 14th day, this index changed in opposite direction, i.e., it began to decrease; however, it was higher relative to the intact group of animals. The obtained factual data evidence that under the conditions of experimental periodontitis formation, there is an intensive increase in the level of oxidative modification of proteins especially in the early period of the inflammatory process development.