Incorporation of a p-Phenylene Unit into the Azuliporphyrinogens Frame-Oxidation and Ruthenium Cluster Coordination.

A porphyrinogen macrocycle incorporating two azulenes, phenylene and thiophene into the framework, joined by four C(sp3 ) atoms has been obtained as a mixture of six isomers. They were successfully separated and characterized spectroscopically. The identity of two of them was confirmed by X-ray crystallography. One isomer was tested in reaction with [Ru3 (CO)12 ] yielding exclusively π-complex with two clusters attached to azulenes. The partial oxidation of porphyrinogens yielded dication with two unmodified meso bridges. The stepwise oxidation followed by reaction with water as nucleophile afforded the dicationic species with two hydroxyl groups and a trication with one OH group. The hydroxy-dication can be reversibly transformed into hydroxy-trication by addition of HBF4 etherate.

Biomechanical properties of the facial retaining ligaments.

OBJECTIVE: Osteocutaneous facial retaining ligaments play an important role in the aging face. We sought to better characterize the biophysical properties of these ligaments and, in doing so, provide an empirical basis for the natural descent seen in facial aging. METHODS: Five fresh frozen cadaver heads yielding 10 hemifaces were dissected to expose the orbital, zygomatic, buccomaxillary, and mandibular osteocutaneous ligaments. Each ligament was assessed and subjected to biomechanical testing. The main outcome measures included ligament dimensions, stiffness, percentage of elongation, and force to initial and ultimate failure. RESULTS: Initial and ultimate failure testing revealed the zygomatic ligament to be strongest, followed by the orbital, mandibular, and maxillary ligaments. The zygomatic ligament was also stiffest, followed by the orbital, maxillary, and mandibular ligaments. The percentage of elongation acted as a surrogate marker of elasticity, with the greatest elasticity maintained by the mandibular ligament, followed by the orbital, zygomatic, and buccomaxillary ligaments. Ligament dimensions and biophysical properties did not vary relative to cadaveric hemiface, age, or sex. CONCLUSIONS: To our knowledge, this is the first investigation to quantify the biomechanical properties of the facial retaining ligaments. Inherent ligament properties seem to be related to the changes observed in facial aging, although further study is required.

Early results using ultrasound-assisted liposuction as a treatment for fat necrosis in breast reconstruction.

BACKGROUND: Fat necrosis is a common complication from autologous breast reconstruction that can compromise the aesthetic outcome and can be confused with recurrent breast cancer. Removal of fat necrosis through direct excision can be difficult with lesions in the periphery and may result in contour deformities. The article describes a case series of patients with fat necrosis treated with ultrasound-assisted liposuction. METHODS: A retrospective database was created consisting of consecutive patients treated with ultrasound-assisted liposuction at a single academic institution. Patient demographics and complications were identified, including initial size of fat necrosis, number of ultrasound-assisted liposuction treatments, and final size of fat necrosis. Surgical technique was standardized over the entire series. RESULTS: There were 54 breast reconstructions with fat necrosis treated with ultrasound-assisted liposuction. The average initial size of fat necrosis was 2.72 cm. Twenty-seven lesions (50.0 percent) were treated once, 20 (37.0 percent) were treated twice, and seven (13.0 percent) were treated three times. The final size of fat necrosis was 0.44 cm (p < 0.0001), with an average time to follow-up of 17.8 months. Complete resolution (<0.5 cm) was seen in 44 lesions (81.5 percent). Only one complication, a thermal burn, was seen from ultrasound-assisted liposuction, and this resolved with conservative management. CONCLUSIONS: This case series describes the successful use of ultrasound-assisted liposuction for treatment of fat necrosis after autologous breast reconstruction. The authors find this technique to be safe, effective, and reproducible, as the majority of fat necrosis areas resolved with one or two treatments.