RESUMO
The visual cortex is very important in mammals for processing of visual information. Exposure to heavy metals such as potassium dichromate poses serious health threat to human beings. The aim of this work is to study the effect of potassium dichromate on the visual cortex of adult albino rat and also to identify the possibility of selenium as protective agent against toxicity of potassium dichromate. A total number of 40 adult albino rats weighting (200-250) gm were used. They divided into four groups: control group, potassium dichromate received group, potassium dichromate and selenium received group and selenium received group. The rats received treatment for 6 weeks. After 6 weeks, they were sacrificed. The present study showed that potassium dichromate causes degeneration of granular neurons in layer IV and pyramidal neurons in layer V. Morphometric results revealed statistically significant decrease in the number of granule and pyramidal cells in potassium dichromate received group as compared with control group. Most of degenerative changes are improved by selenium.
اÙدÙر اÙÙÙائ٠اÙÙ Øت٠٠ÙÙسÙÙÙÙÙÙ٠عÙ٠اÙÙشرة اÙÙ Ø®ÙØ© اÙبصرÙØ© ÙÙÙأر اÙابÙض اÙباÙغ عÙد اÙتعرضÙÙداÙÙرÙ٠ات اÙبÙتاسÙÙ٠ساÙ٠سÙد Ø£ÙÙر-ÙاÙØ© Ù Ø٠د ØساÙÙÙÙس٠اÙتشرÙØ Ø§Ùاد٠٠ÙعÙ٠اÙاجÙØ© -ÙÙÙØ© اÙطب اÙبشرÙ- جا٠عة اسÙÙطاÙÙشرة اÙبصرÙØ© Ù ÙÙ Ø© جدا Ù٠اÙثدÙÙات Ù٠عاÙجة اÙ٠عÙÙ٠ات اÙ٠رئÙØ©. ÙØ´Ù٠اÙتعرض ÙÙ٠عادÙاÙØ«ÙÙÙØ© Ù Ø«Ù Ø«Ùائ٠ÙرÙ٠ات اÙبÙتاسÙÙ٠تÙدÙدا٠صØÙا٠خطÙرا٠ÙÙØ¥ÙساÙ. اÙÙد٠٠٠Ùذا اÙع٠٠ÙÙدراسة تأثÙر Ø«Ùائ٠ÙرÙ٠ات اÙبÙتاسÙÙ٠عÙ٠اÙÙشرة اÙبصرÙØ© Ùجرذ Ø£ÙبÙÙ٠اÙباÙغ ÙÙØ°Ù٠اÙتعرÙعÙ٠إ٠ÙاÙÙØ© استخدا٠اÙسÙÙÙÙÙÙÙ Ùعا٠٠ÙÙائ٠ضد س٠ÙØ© Ø«Ùائ٠ÙرÙ٠ات اÙبÙتاسÙÙÙ . ت٠استخدا٠جرذ ٠٠اÙجرذا٠اÙباÙغة ÙزÙÙا (200-250) جرا٠. ت٠تÙسÙÙ Ù٠إÙÙ 4 ٠ج٠Ùعات: اÙ٠ج٠Ùعة40اÙضابطة Ø Ø§Ù٠ج٠Ùعة اÙ٠ستÙÙ Ø© Ø«Ùائ٠ÙرÙ٠ات اÙبÙتاسÙÙÙ Ø Ø§Ù٠ج٠Ùعة اÙ٠ستÙÙ Ø© ثاÙÙ ÙرÙ٠اتاÙبÙتاسÙÙÙ ÙاÙسÙÙÙÙÙÙ٠اÙ٠ج٠Ùعة اÙ٠ستÙÙ Ø© سÙÙÙÙÙÙ٠تÙÙتاÙÙئرا٠اÙعÙاج Ù٠دة 6أسابÙع. بعد ستة أسابÙع ت٠اÙتضØÙØ© بÙÙ . أظÙرت اÙدراسة اÙØاÙÙØ© Ø£Ù Ø«Ùائ٠ÙرÙ٠ات اÙبÙتاسÙÙÙ Ùسبب تÙÙس اÙØ®ÙاÙا اÙعصبÙØ© اÙØبÙبÙØ© Ù٠اÙطبÙØ© اÙرابعة ÙاÙØ®ÙاÙا اÙعصبÙØ© اÙÙر٠ÙØ© Ù٠اÙطبÙةاÙخا٠سة. أظÙرت Ùتائج اÙÙÙاس اÙÙ ÙرÙÙ٠تر٠اÙØ®ÙاضÙا ذا دÙاÙØ© Ø¥ØصائÙØ© Ù٠عدد اÙØ®ÙاÙا اÙØبÙبÙØ©ÙاÙÙر٠ÙØ© Ù٠اÙ٠ج٠Ùعة اÙت٠ت٠تÙÙÙÙا Ù Ù Ø«Ùائ٠ÙرÙ٠ات اÙبÙتاسÙÙÙ Ù ÙارÙØ© ب٠ج٠Ùعة اÙتØÙÙ . Ùت٠تØسÙ٠٠عظ٠اÙتغÙÙرات اÙتÙÙسÙØ© بÙاسطة اÙسÙÙÙÙÙÙÙ .[Figure: see text].
Assuntos
Selênio , Córtex Visual , Ratos , Humanos , Adulto , Animais , Dicromato de Potássio/toxicidade , Selênio/farmacologia , MamíferosRESUMO
Obesity is a serious health issue. As regard, the central nervous system, obesity induces neuronal damage. Vitamin D has well-known anti-inflammatory and neuroprotective effects. To detect if vitamin D protects against damage in the arcuate nucleus induced by a high fat-high fructose diet. Forty adult rats were used, and four groups were formed. Group I (negative control) kept on a standard chow diet for six weeks, Group II (positive control) received vitamin D orally once every other day for six weeks, Group III (high fat-high fructose treated group) was given high fat-high fructose diets for six weeks and Group IV (high fat-high fructose and vitamin D treated group) were given high fat-high fructose diets concomitantly with vitamin D for six weeks. High fat-high fructose diet markedly caused histological changes in arcuate neurons as nuclei appeared darkly stained and shrunken with condensed chromatin, and the nucleolus became less prominent. The cytoplasm appeared rarefied with loss of most of the organelles. An increase in neuroglial cells was noticed. The synaptic area showed sparse degenerated mitochondria and a disrupted presynaptic membrane. A high-fat diet has a damaging effect on arcuate neurons and vitamin D alleviates these effects.