1.
Tijdschr Psychiatr
; 55(9): 695-705, 2013.
Artigo
em Holandês
| MEDLINE
| ID: mdl-24046248
RESUMO
BACKGROUND: Plasma levels can be used to monitor the clinical efficacy of tricyclic antidepressants (TCAs). In practice, the interpretation of plasma levels can be problematical, for several reasons: varying time-intervals between ingestion and blood sampling, the number of times per day a particular antidepressant is administered, the presence of active metabolites and the use of slow-release substances. AIM: To present realistic recommendations regarding the interpretation of plasma levels of TCA in clinical practice. METHOD: We studied the relevant literature. CONCLUSION: On the basis of the literature we make the following recommendations: