RESUMO
A total of 53 subjects with working exposure to styrene (1-29 years) has been investigated. On lipid and lipoproteins examination, only 8 persons (15%) showed normal values. The amount of 26 (49%) persons had the increase in HDL-cholesterol values. Subjects with protracted exposure to styrene (11-29 years) had higher level of cholesterol, absolute HDL-cholesterol values, total VLDLs and atherogenic index as compared to those which have worked at risk of styrene for 1-10 years. However, there was no statistically significant difference. Occupationnaly styrene exposed persons had statistically higher HDL-cholesterol (expressed both absolutely and relatively) in comparison with 21 clinically healthy controls. Changes of total cholesterol, VLDLs and of atherogenic index may partly be explained with factor of age. However, this is no such an explanation for HDL-cholesterol, since in adverse to that it decreases with more age in a normal population. Authors assume the pathologically higher HDL-cholesterol levels may exhibit causal interaction with occupational exposure to styrene, probably through the induction of microsomal liver enzymatic systems.
Assuntos
Lipídeos/sangue , Lipoproteínas/sangue , Exposição Ocupacional , Estirenos/farmacologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Lipoproteínas/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , EstirenoRESUMO
Permanent and systematical attention must be paid to the care how to protect health of workers in processes of freeze-drying and conservation of biological objects by means of low temperatures. Biohazards include also development of occupational diseases. Preventive care provided to workers is recommended in the form of admission and periodical checks. Some other own experience is presented in this paper, valid health service regulations are quoted together with recommendation how to prevent occupational injuries and secure observation of the above regulations by the employer organizations.
