1.
Angew Chem Int Ed Engl
; 43(47): 6500-5, 2004 Dec 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15578773
2.
Org Lett
; 6(21): 3833-6, 2004 Oct 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15469361
RESUMO
[reaction: see text] C-1027, an extremely potent antitumor agent, is composed of chromophore 1 and an apoprotein. Here we report a general and efficient route to the exceedingly reactive bicyclo[7.3.0]dodecatrienediyne core of 1, utilizing selenoxide elimination and epoxide deoxygenation to build the cyclopentadiene and enediyne structures, respectively.