1.
Bioorg Med Chem
; 13(19): 5680-5, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15964195
RESUMO
The potential of novel and known pyridyl thiourea derivatives (non-nucleoside inhibitors (NNI) of HIV reverse transcriptase) as bifunctional organic catalysts in the asymmetric Strecker synthesis was investigated. It was shown that incorporation of the imidazolyl moiety in place of a pyridyl group results in a new thiourea derivative that displays a much higher catalytic activity.