1.
Immunol Today
; 21(12): 615-9, 2000 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11114421
RESUMO
Helicobacter pylori causes peptic ulcer disease and some forms of gastric cancer; it is one of the most common chronic bacterial infections of humans. Although several prototype protein-based vaccines have shown promising results, they have not cleared infection and/or prevented reinfection. Nucleic acid vaccination offers a useful alternative to protein immunization, especially now that two complete H. pylori genome sequences are available, and facilitates the selection of antigenic targets.