Reproducible stability of verbal and spatial functions along the menstrual cycle.

Recent studies have reported brain changes in response to ovarian hormonal fluctuations along the menstrual cycle. However, it remains unclear, whether these brain changes are of an adaptive nature or whether they are linked to changes in behavior along the menstrual cycle, particularly with respect to cognitive performance. To address this knowledge gap, we report results from 3 well-powered behavioral studies with different task designs, leveraging the advantages of each design type. In all three studies we assessed whether verbal or spatial performance (i) differed between cycle phases, (ii) were related to estradiol and / or progesterone levels and (iii) were moderated by individual hormone sensitivity as estimated by premenstrual symptoms. Overall, results of all three studies point towards a null effect of menstrual cycle phase and - to a lesser extent - ovarian hormones on verbal and spatial performance and provided no evidence for a moderation of this effect by individual hormone sensitivity. We conclude that there is substantial consistency in verbal and spatial performance across the menstrual cycle, and that future studies of intra-individual variation are needed.

Sex hormones modulate sex differences and relate to hemispheric asymmetries in a divided visual field Navon task.

Sex differences in functional hemispheric asymmetries (FHA) have been hypothesized as a fundamental mechanism behind sex differences in global-local processing. So far, it has not been assessed how interactive effects of sex and hemifield presentation influence common indicators of global precedence. The current study is the first to investigate the involvement of FHAs by using a divided visual field Navon paradigm and controlling for sex hormone status. Moreover, various factors that have previously shown a reliable influence on global-local processing performance are verified within the context of unilateral presentation. 39 men and 39 naturally cycling women in their luteal cycle phase completed a divided visual field Navon task with the instruction to detect targets either at any level (divided attention) or only at the global or local level (selective attention) in three different spacing conditions. The obtained evidence reveals significant sex differences in the global advantage effect (faster reaction to global vs. local level targets) for densely spaced letter stimuli, as well as significant sex differences in global-local level interference, with findings on both measures being mediated by testosterone. Also, estradiol showed different relationships to the global advantage effect in men and women together with a positive relationship to global advantage for the selective attention condition. Behavioural reaction time results were mirrored by accuracy measures but presented significantly higher global- over local-level accuracy in women compared to men for the divided attention condition. Our results did not show significant sex differences in FHAs but indicate differential relationships between progesterone and FHAs in men and women. In conclusion, sex hormones emerged as central mediators of sex differences in global precedence and possible moderators of hemispheric asymmetries.