RESUMO
Oxalate kidney stones are common and exert a huge burden of morbidity worldwide. However, circulating or excreted concentrations of oxalate are rarely measured. We argue that oxalate and its metabolism are important above and beyond kidney stone formation. There is emerging evidence that increased concentrations of oxalate could be a driver of chronic kidney disease progression. Furthermore, oxalate has been implicated in cardiovascular disease. Thus, the reduction of elevated plasma oxalate concentrations may represent a novel cardioprotective and nephroprotective strategy.
Assuntos
Doenças Cardiovasculares , Cálculos Renais , Oxalatos , Humanos , Cálculos Renais/metabolismo , Cálculos Renais/etiologia , Doenças Cardiovasculares/metabolismo , Doenças Cardiovasculares/etiologia , Oxalatos/metabolismo , Progressão da Doença , Insuficiência Renal Crônica/metabolismoRESUMO
This cross-sectional audit investigates the prevalence and determinants of anemia in older people with diabetes attending an outpatient clinic. Anemia was found to be highly prevalent, affecting 59% of patients. Older age and longer duration of diabetes were the main predictors of anemia, whereas the presence of chronic kidney disease was a mediator rather than a direct cause.
