RESUMO
Although advances in immunosuppression and antimicrobial prophylaxis have led to improved patient and graft survival, respiratory viruses continue to be a common cause of morbidity and mortality in immunocompromised populations. We describe the clinical manifestations, diagnosis and treatment options for influenza, respiratory syncytial virus and adenovirus infection in the kidney transplant population.
Assuntos
Infecções por Adenovirus Humanos/induzido quimicamente , Rejeição de Enxerto/prevenção & controle , Imunossupressores/efeitos adversos , Influenza Humana/induzido quimicamente , Falência Renal Crônica/cirurgia , Transplante de Rim , Infecções por Vírus Respiratório Sincicial/induzido quimicamente , Infecções Respiratórias/induzido quimicamente , Infecções por Adenovirus Humanos/diagnóstico , Infecções por Adenovirus Humanos/terapia , Antivirais/uso terapêutico , Humanos , Vacinas contra Influenza/uso terapêutico , Influenza Humana/diagnóstico , Influenza Humana/prevenção & controle , Influenza Humana/terapia , Infecções por Vírus Respiratório Sincicial/diagnóstico , Infecções por Vírus Respiratório Sincicial/terapia , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/terapiaRESUMO
A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus. Next-generation sequencing and phylogenetic analysis identified the virus as a novel member of the genus Thogotovirus.
