RESUMO
Loeys-Dietz is a multisystem congenital syndrome that comprises craniofacial and cutaneous abnormalities as well as structural cardiac defects. One of its key pathological features is an aggressive widespread vasculopathy that can manifest as aortic or cerebral aneurysms, which is prone to dissection and rupture. We report a case of a large aneurysm of the ductus arteriosus in a patient with Loeys-Dietz syndrome, successfully occluded by interventional catheterization.
Assuntos
Aneurisma/diagnóstico por imagem , Aneurisma/terapia , Aortografia/métodos , Cateterismo Cardíaco , Canal Arterial/diagnóstico por imagem , Cardiopatias/diagnóstico por imagem , Cardiopatias/terapia , Síndrome de Loeys-Dietz/complicações , Tomografia Computadorizada por Raios X , Aneurisma/complicações , Cateterismo Cardíaco/instrumentação , Cardiopatias/complicações , Humanos , Lactente , Síndrome de Loeys-Dietz/diagnóstico , Síndrome de Loeys-Dietz/genética , Masculino , Valor Preditivo dos Testes , Resultado do TratamentoRESUMO
Records of 11 cats with transitional cell carcinoma of the urinary bladder, which had been treated with meloxicam, were reviewed for signalment, duration of clinical signs prior to diagnosis, results of diagnostic imaging, whether or not concurrent surgery was performed and survival. Immunohistochemical expression of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) was assessed in the tumours of seven cats. Tumour location varied greatly. The cats had a mean age of 13 years. Three cats had a previous diagnosis of feline idiopathic cystitis of up to 2008 days duration. Ten of the cats showed clinical improvement (reduction of haematuria and/or dysuria), with a mean survival time (MST) of 311 days (range 10-1064); 1-year survival of 50%. All seven bladders assessed for COX staining were COX-1 positive and five were COX-2 positive. The MST for the COX-2-positive cats was 123 days, the MST for the COX-2-negative cases was 375 days.
Assuntos
Carcinoma de Células de Transição/veterinária , Doenças do Gato/tratamento farmacológico , Doenças do Gato/metabolismo , Ciclo-Oxigenase 1/metabolismo , Ciclo-Oxigenase 2/metabolismo , Tiazinas/farmacologia , Tiazóis/farmacologia , Neoplasias da Bexiga Urinária/veterinária , Animais , Carcinoma de Células de Transição/tratamento farmacológico , Carcinoma de Células de Transição/metabolismo , Carcinoma de Células de Transição/mortalidade , Doenças do Gato/mortalidade , Gatos , Ciclo-Oxigenase 1/efeitos dos fármacos , Ciclo-Oxigenase 2/efeitos dos fármacos , Feminino , Imunoquímica , Isoenzimas/antagonistas & inibidores , Masculino , Meloxicam , Proteínas de Neoplasias/metabolismo , Análise de Sobrevida , Tiazinas/administração & dosagem , Tiazóis/administração & dosagem , Neoplasias da Bexiga Urinária/tratamento farmacológico , Neoplasias da Bexiga Urinária/metabolismo , Neoplasias da Bexiga Urinária/mortalidadeRESUMO
It has been suggested previously that rebound hypercoagulability may be responsible for morbidity and mortality following clopidogrel cessation in adults with acute coronary syndrome. We report a case of acute occlusion of a modified Blalock-Taussig shunt in an infant after clopidogrel discontinuation.
