Effects of Central Metal Ion on Binuclear Metal Phthalocyanine-Based Redox Mediator for Lithium Carbonate Decomposition.

Li2CO3 is the most tenacious parasitic solid-state product in lithium-air batteries (LABs). Developing suitable redox mediators (RMs) is an efficient way to address the Li2CO3 issue, but only a few RMs have been investigated to date, and their mechanism of action also remains elusive. Herein, we investigate the effects of the central metal ion in binuclear metal phthalocyanines on the catalysis of Li2CO3 decomposition, namely binuclear cobalt phthalocyanine (bi-CoPc) and binuclear cobalt manganese phthalocyanine (bi-CoMnPc). Density functional theory (DFT) calculations indicate that the key intermediate peroxydicarbonate (*C2O62-) is stabilized by bi-CoPc2+ and bi-CoMnPc3+, which is accountable for their excellent catalytic effects. With one central metal ion substituted by manganese for cobalt, the bi-CoMnPc's second active redox couple shifts from the second Co(II)/Co(III) couple in the central metal ion to the Pc(-2)/Pc(-1) couple in the phthalocyanine ring. In artificial dry air (N2-O2, 78:22, v/v), the LAB cell with bi-CoMnPc in electrolyte exhibited 261 cycles under a fixed capacity of 500 mAh g-1carbon and current density of 100 mA g-1carbon, significantly better than the RM-free cell (62 cycles) and the cell with bi-CoPc (193 cycles).

Nomogram to Predict the Outcome of Ventriculoperitoneal Shunt Among Patients with Non-HIV Cryptococcal Meningitis.

BACKGROUND: The ventriculoperitoneal (VP) shunt is widely acknowledged as a treatment option for managing intracranial hypertension resulting from non-human immunodeficiency virus (HIV) cryptococcal meningitis (CM). Nonetheless, there is currently no consensus on the appropriate surgical indications for this procedure. Therefore, it is crucial to conduct a preoperative evaluation of patient characteristics and predict the outcome of the VP shunt to guide clinical treatment effectively. METHODS: A retrospective analysis was conducted on data from 85 patients with non-HIV CM who underwent VP shunt surgery at our hospital. The analysis involved studying demographic data, preoperative clinical manifestations, cerebrospinal fluid (CSF) characteristics, and surgical outcomes and comparisons between before and after surgery. A nomogram was developed and evaluated. RESULTS: The therapy outcomes of 71 patients improved, whereas 14 cases had worse outcomes. Age, preoperative cryptococcus count, and preoperative CSF protein levels were found to influence the surgical outcome. The nomogram exhibited exceptional predictive performance (area under the curve = 0.896, 95% confidence interval: 0.8292-0.9635). Internal validation confirmed the nomogram's excellent predictive capabilities. Moreover, decision curve analysis demonstrated the nomogram's practical clinical utility. CONCLUSIONS: The surgical outcome of VP shunt procedures patients with non-HIV CM was associated with age, preoperative cryptococcal count, and preoperative CSF protein levels. We developed a nomogram that can be used to predict surgical outcomes in patients with non-HIV CM.

Simple and Safe Synthesis of Yolk-Shell-Structured Silicon/Carbon Composites with Enhanced Electrochemical Properties.

With its substantial theoretical capacity, silicon (Si) is a prospective anode material for high-energy-density lithium-ion batteries (LIBs). However, the challenges of a substantial volume expansion and inferior conductivity in Si-based anodes restrict the electrochemical stability. To address this, a yolk-shell-structured Si-carbon composite, featuring adjustable void sizes, was synthesized using tin (Sn) as a template. A uniform coating of tin oxide (SnO2) on the surface of nano-Si particles was achieved through a simple annealing process. This approach enables the removal of the template with concentrated hydrochloric acid (HCl) instead of hydrofluoric acid (HF), thereby reducing toxicity and corrosiveness. The conductivity of Si@void@Carbon (Si@void@C) was further enhanced by using a high-conductivity carbon layer derived from pitch. By incorporating an internal void, this yolk-shell structure effectively enhanced the low Li+/electron conductivity and accommodated the large volume change of Si. Si@void@C demonstrated an excellent electrochemical performance, retaining a discharge capacity of 735.3 mAh g-1 after 100 cycles at 1.0 A g-1. Even at a high current density of 2.0 A g-1, Si@void@C still maintained a discharge capacity of 1238.5 mAh g-1.

Prechiasmatic Transection of the Unilateral Dodge Class â Optic Pathway Glioma without Neurofibromatosis Type 1: Technical Description and Clinical Prognosis.

OBJECTIVE: For unilateral Dodge Class Ⅰ optic pathway glioma (OPG-uDCⅠ) without neurofibromatosis type 1, unilateral isolated optic nerve gliomas before the optic chiasm have been confirmed to possibly cause visual deterioration and poor prognosis. For this type of highly selective localized tumor, we explored surgery as the only treatment method. This article retrospectively analyzed and summarized the clinical data of this case series, with the aim of exploring the main technical details and clinical prognosis. METHODS: Included were patients with OPG-uDCⅠ without neurofibromatosis type 1 and experiencing vision loss on the affected side. The fronto-orbital approach was used, which was mainly divided into 3 parts: intraorbital, optic canal, and intracranial. All patients underwent prechiasmatic resection without any adjuvant treatments. The follow-up period was 3 months after surgery, and magnetic resonance imaging and contralateral visual acuity were reviewed annually after surgery. RESULTS: All OPG-uDCⅠ cases were completely removed without any adjuvant treatments, and there was no recurrence during the follow-up period. Pathological results showed that, except for 1 adult patient with pilomyxoid astrocytoma (World Health Organization grade Ⅱ), the others all had pilocytic astrocytoma (World Health Organization grade Ⅰ). Five patients experienced transient ptosis, and all recovered 3 months after surgery. CONCLUSIONS: For OPG-uDCⅠ without neurofibromatosis type 1, radical prechiasmatic resection of the tumor is possible, without the need for postoperative radiotherapy and chemotherapy.

Clinical Characteristics and Prognostic Analysis of Osteolytic and Hyperostosis Sphenoid Orbital Meningiomas: A Single-Center Experience.

Reactive hyperostosis of spheno-orbital meningiomas (SOMs) often occurred in the sphenoid wing, while osteolytic SOMs (O-SOMs) were rarely discussed. This study preliminarily evaluated the clinical characteristics of O-SOMs and analyzed prognostic factors affecting the recurrence of SOMs. We retrospectively analyzed the medical records of consecutive patients who underwent surgery for a SOM between 2015 and 2020. According to the bone changes of sphenoid wing, SOMs were divided into O-SOMs and hyperostosis SOMs (H-SOMs). A total of 31 procedures were performed in 28 patients. All cases were treated by pterional-orbital approach. It was confirmed that 8 cases were O-SOMs and the other 20 cases were H-SOMs. Total tumor resection was performed in 21 cases. There were 19 cases with Ki 67 ≥3%. The patients were followed up for 3 to 87 months. Proptosis improved in all patients. All O-SOMs had no visual deterioration, while 4 H-SOMs cases had visual deterioration. There was no significant difference in clinical outcomes between the two types of SOM. The recurrence of SOM was related to the degree of resection, but not to the type of bone lesions, invasion of cavernous sinus and Ki 67.

Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors.

Deficits in astrocyte function contribute to major depressive disorder (MDD) and suicide, but the therapeutic effect of directly reactivating astrocytes for depression remains unclear. Here, specific gains and losses of astrocytic cell functions in the medial prefrontal cortex (mPFC) bidirectionally regulate depression-like symptoms. Remarkably, recombinant human Thrombospondin-1 (rhTSP1), an astrocyte-secreted protein, exerted rapidly antidepressant-like actions through tyrosine hydroxylase (Th)/dopamine (DA)/dopamine D2 receptors (D2Rs) pathways, but not dopamine D1 receptors (D1Rs), which was dependent on SH3 and multiple ankyrin repeat domains 3 (Shank3) in the mPFC. TSP1 in the mPFC might have potential as a target for treating clinical depression.

A Multifunctional Coating on Sulfur-Containing Carbon-Based Anode for High-Performance Sodium-Ion Batteries.

A sulfur doping strategy has been frequently used to improve the sodium storage specific capacity and rate capacity of hard carbon. However, some hard carbon materials have difficulty in preventing the shuttling effect of electrochemical products of sulfur molecules stored in the porous structure of hard carbon, resulting in the poor cycling stability of electrode materials. Here, a multifunctional coating is introduced to comprehensively improve the sodium storage performance of a sulfur-containing carbon-based anode. The physical barrier effect and chemical anchoring effect contributed by the abundant C-S/C-N polarized covalent bond of the N, S-codoped coating (NSC) combine to protect SGCS@NSC from the shuttling effect of soluble polysulfide intermediates. Additionally, the NSC layer can encapsulate the highly dispersed carbon spheres inside a cross-linked three-dimensional conductive network, improving the electrochemical kinetic of the SGCS@NSC electrode. Benefiting from the multifunctional coating, SGCS@NSC exhibits a high capacity of 609 mAh g-1 at 0.1 A g-1 and 249 mAh g-1 at 6.4 A g-1. Furthermore, the capacity retention of SGCS@NSC is 17.6% higher than that of the uncoated one after 200 cycles at 0.5 A g-1.

Interlayer-Expanded MoS2 Enabled by Sandwiched Monolayer Carbon for High Performance Potassium Storage.

Potassium-ion batteries (PIBs) have aroused a large amount of interest recently due to the plentiful potassium resource, which may show cost benefits over lithium-ion batteries (LIBs). However, the huge volume expansion induced by the intercalation of large-sized potassium ions and the intrinsic sluggish kinetics of the anode hamper the application of PIBs. Herein, by rational design, nano-roses assembled from petals with a MoS2/monolayer carbon (C-MoS2) sandwiched structure were successfully synthesized. The interlayer distance of ultrathin C-MoS2 was expanded from original MoS2 of 6.2 to 9.6 Å due to the formation of the MoS2-carbon inter overlapped superstructure. This unique structure efficiently alleviates the mechanical strain, prevents the aggregation of MoS2, creates more active sites, facilitates electron transport, and enhances the specific capacity and K+ diffusion kinetics. As a result, the prepared C-MoS2-1 anode delivers a high reversible specific capacity (437 mAh g-1 at 0.1 A g-1) and satisfying rate performance (123 mAh g-1 at 6.4 A g-1). Therefore, this work provides new insights into the design of high-performance anode materials of PIBs.

Nano-Silicon@Exfoliated Graphite/Pyrolytic Polyaniline Composite of a High-Performance Cathode for Lithium Storage.

In this paper, a Si@EG composite was prepared by liquid phase mixing and the elevated temperature solid phase method, while polyaniline was synthesized by the in situ chemical polymerization of aniline monomer to coat the surface of nano-silicon and exfoliated graphite composites (Si@EG). Pyrolytic polyaniline (p-PANI) coating prevents the agglomeration of silicon nanoparticles, forming a good conductive network that effectively alleviates the volume expansion effect of silicon electrodes. SEM, TEM, XRD, Raman, TGA and BET were used to observe the morphology and analyze the structure of the samples. The electrochemical properties of the materials were tested by the constant current charge discharge and cyclic voltammetry (CV) methods. The results show that Si@EG@p-PANI not only inhibits the agglomeration between silicon nanoparticles and forms a good conductive network but also uses the outermost layer of p-PANI carbon coating to effectively alleviate the volume expansion of silicon nanoparticles during cycling. Si@EG@p-PANI had a high initial specific capacity of 1491 mAh g-1 and still maintains 752 mAh g-1 after 100 cycles at 100 mA g-1, which shows that it possesses excellent electrochemical stability and reversibility.

Silicon/Graphite/Amorphous Carbon as Anode Materials for Lithium Secondary Batteries.

Although silicon is being researched as one of the most promising anode materials for future generation lithium-ion batteries owing to its greater theoretical capacity (3579 mAh g-1), its practical applicability is hampered by its worse rate properties and poor cycle performance. Herein, a silicon/graphite/amorphous carbon (Si/G/C) anode composite material has been successfully prepared by a facile spray-drying method followed by heating treatment, exhibiting excellent electrochemical performance compared with silicon/amorphous carbon (Si/C) in lithium-ion batteries. At 0.1 A g-1, the Si/G/C sample exhibits a high initial discharge capacity of 1886 mAh g-1, with a high initial coulombic efficiency of 90.18%, the composite can still deliver a high initial charge capacity of 800 mAh g-1 at 2 A g-1, and shows a superior cyclic and rate performance compared to the Si/C anode sample. This work provides a facile approach to synthesize Si/G/C composite for lithium-ion batteries and has proven that graphite replacing amorphous carbon can effectively improve the electrochemical performance, even using low-performance micrometer silicon and large size flake graphite.

Percutaneous transluminal angioplasty for radial artery graft stenosis after high-flow superficial temporal artery trunk to middle cerebral artery interposition bypass.

Due to its higher patency rate, a radial artery graft (RAG) is used as an interposition graft for internal-external high-flow bypass more frequently than a saphenous vein graft (SAG). Nevertheless, there are still a few cases of RAG stenosis after bypass surgery. Unfortunately, these reports do not elaborate on the treatment for RAG stenosis. Here, we report the first case of severe RAG stenosis after high-flow STAt-RA-MCA bypass, which was successfully treated with PTA. We speculated that RAG stenosis is associated with the over-length and kinking of the intracranial segment of the RAG instead of vasospasm. We elaborated on the surgical procedure and treatment experience in this particular case in detail. According to our experience, PTA is a type of surgical procedure that can be considered for treating RAG stenosis after high-flow bypass. As long as the surgical procedure can be performed well according to the distance between the stenosis and the anastomosis and the characteristics of the RA tissue, PTA is able to achieve satisfactory long-term results.

A New Concept for Primary Reconstruction of Skull Defects with 3D-Molded PEEK Patch Assisted by Navigation Based on Animal Study.

AIM: To perform an accurate primary repair of temporal bone defects. MATERIAL AND METHODS: The temporal bone defect models were performed in beagles. Extended estimated patches of the defects were predesigned by 3D reconstruction software and molded from polyether ether ketone (PEEK) using a lathe. The precise trimming of the extended PEEK patches was established via coordinate transformation of the patches between the navigation system and the reconstruction software, and in real-time tracing via intraoperative navigation. Trimmed PEEK patches were embedded onto the defects. Blood tests and image examinations were conducted postoperatively. RESULTS: The extended PEEK patches were prepared precisely according to the predesign. Real-time tracing of the actual skull defect profile was performed quickly and accurately. Trimmed skull patches perfectly matched the shape of the defects. No signs of infection, absorption, or translocation of the patches occurred postoperatively, and little epidural effusion was found. CONCLUSION: With the assistance of navigation and 3D reconstruction technology, customized molded PEEK patches can be used for accurate primary repair of temporal bone defects.

Integrated genetic analysis of leaf blast resistance in upland rice: QTL mapping, bulked segregant analysis and transcriptome sequencing.

Elite upland rice cultivars have the advantages of less water requirement along with high yield but are usually susceptible to various diseases. Rice blast caused by Magnaporthe oryzae is the most devastating disease in rice. Identification of new sources of resistance and the introgression of major resistance genes into elite cultivars are required for sustainable rice production. In this study, an upland rice genotype UR0803 was considered an emerging source of blast resistance. An F2 mapping population was developed from a cross between UR0803 and a local susceptible cultivar Lijiang Xintuan Heigu. The individuals from the F2 population were evaluated for leaf blast resistance in three trials 7 days after inoculation. Bulked segregant analysis (BSA) by high-throughput sequencing and SNP-index algorithm was performed to map the candidate region related to disease resistance trait. A major quantitative trait locus (QTL) for leaf blast resistance was identified on chromosome 11 in an interval of 1.61-Mb genomic region. The candidate region was further shortened to a 108.9-kb genomic region by genotyping the 955 individuals with 14 SNP markers. Transcriptome analysis was further performed between the resistant and susceptible parents, yielding a total of 5044 differentially expressed genes (DEGs). There were four DEGs in the candidate QTL region, of which, two (Os11g0700900 and Os11g0704000) were upregulated and the remaining (Os11g0702400 and Os11g0703600) were downregulated in the susceptible parent after inoculation. These novel candidate genes were functionally annotated to catalytic response against disease stimulus in cellular membranes. The results were further validated by a quantitative real-time PCR analysis. The fine-mapping of a novel QTL for blast resistance by integrative BSA mapping and transcriptome sequencing enhanced the genetic understanding of the mechanism of blast resistance in upland rice. The most suitable genotypes with resistance alleles would be useful genetic resources in rice blast resistance breeding.

Strengthen Synergistic Effect of Soft Carbon and Hard Carbon Toward High-Performance Anode for K-Ion Battery.

Synergistic effect of soft carbon and hard carbon has been proven to be useful for obtaining excellent anode materials for potassium ion battery, which is determined by the mixing degree of precursors. Inspired by the formation of proteins in biology, peptide bonds are used to connect the precursors of the two sort of carbon to prepare soft-hard hybrid carbons with stronger synergistic effects. The hard carbon domain with nanometer size is so highly distributed in the soft carbon that the synergistic effect between two sorts of carbon is significantly enhanced. After the optimization, the diffusion coefficient of as-prepared hybrid carbon (CSHC3-6-1200) is 10 times larger than that of corresponding carbon synthesized by physical method. Consequently, CSHC3-6-1200 can maintain a specific capacity of 71.6 mAh g-1 at a high current density of 1600 mA g-1. It is believed that this new preparation route may bring a new perspective to the development of soft and hard composite carbon material anodes with high power density and ultralong service life.

Trans-eyebrow supraorbital keyhole approach for suprasellar and intra-suprasellar Rathke cleft cysts: the experience of 16 cases and a literature review.

BACKGROUND: Purely suprasellar and some complex intra-suprasellar Rathke cleft cysts (RCCs) are commonly treated via extended endonasal endoscopic approach or traditional transcranial approach. The feasibility of the trans-eyebrow supraorbital keyhole approach (TSKA) for RCCs was evaluated in this retrospective study. METHODS: A cohort of 16 patients (11 females and 5 males) with RCC was surgically treated via TSKA between January 2013 and November 2021. The medical data and follow-up results were analyzed. RESULTS: Eight patients had a purely suprasellar RCC, and 8 patients had an intra-suprasellar RCC with most of pituitary gland occupying the sellar floor. The mean maximal size of the cysts was 15.4 (range 7-29) mm. Postoperatively, complete cyst drainage was achieved in 15 (93.7%) patients. Preoperative headache, visual dysfunction, and hypopituitarism improved in 12 (100.0%), 3 (75.0%) and 3 (75.0%) patients, respectively, and hyperprolactinemia normalized in all patients. Except 2 (12.5%) cases of transient diabetes insipidus (TDI), no other complications were observed. During the mean follow-up period of 41.0 (range 4-102) months, 1 (6.3%) radiological recurrence was found. CONCLUSIONS: For the treatment of purely suprasellar and some intra-suprasellar RCCs with most of the pituitary occupying the sellar floor, the endoscopic TSKA has the advantage of the minimal invasiveness, excellent visualization of the intrasellar compartment, no additional damage to the underlying pituitary gland, and no risk of CSF leakage. TDI or DI is relative commonly found in treatment of these RCCs. During surgery, care should be taken to avoid damage to the surrounding structures, including the pituitary stalk.

Ultra-Thin Wrinkled Carbon Sheet as an Anode Material of High-Power-Density Potassium-Ion Batteries.

Although K+ is readily inserted into graphite, the volume expansion of graphite of up to 60% upon the formation of KC8, together with its slow diffusion kinetics, prevent graphite from being used as an anode for potassium-ion batteries (PIBs). Soft carbon with low crystallinity and an incompact carbon structure can overcome these shortcomings of graphite. Here, ultra-thin two-dimensional (2D) wrinkled soft carbon sheets (USCs) are demonstrated to have high specific capacity, excellent rate capability, and outstanding reversibility. The wrinkles themselves prevent the dense stacking of micron-sized sheets and provide sufficient space to accommodate the volume change of USCs during the insertion/extraction of K+. The ultra-thin property reduces strain during the formation of K-C compounds, and further maintains structural stability. The wrinkles and heteroatoms also introduce abundant edge defects that can provide more active sites and shorten the K+ migration distance, improving reaction kinetics. The optimized USC20-1 electrode exhibits a reversible capacity of 151 mAh g-1 even at 6400 mA g-1, and excellent cyclic stability up to 2500 cycles at 1000 mA g-1. Such comprehensive electrochemical performance will accelerate the adoption of PIBs in electrical energy applications.

Nonoxid-HMGB1 Attenuates Cognitive Impairment After Traumatic Brain Injury in Rats.

Traumatic brain injury (TBI) is a major global burden of health. As an accepted inflammatory mediator, high mobility group box 1 (HMGB1) is found to be effective in facilitating neurogenesis and axonal regeneration. SH3RF2 (also known as POSHER), an E3 ligase SH3 domain-containing ring finger 2, belongs to the SH3RF family of proteins. Here, we aimed to investigate the role of redox states of HMGB1 on neurite outgrowth and regeneration both in vitro and in vivo. In this study, distinct recombinant HMGB1 redox isoforms were used. Sequencing for RNA-seq and data analysis were performed to find the potential downstream target of nonoxid-HMGB1 (3S-HMGB1). Protein changes and distribution of SH3RF2 were evaluated by western blot assays and immunofluorescence. Lentivirus and adeno-associated virus were used to regulate the expression of genes. Nonoxid-HMGB1-enriched exosomes were constructed and used to treat TBI rats. Neurological function was evaluated by OF test and NOR test. Results demonstrated that nonoxid-HMGB1 and fr-HMGB1, but not ds-HMGB1, promoted neurite outgrowth and axon elongation. RNA-seq and western blot assay indicated a significant increase of SH3RF2 in neurons after treated with nonoxid-HMGB1 or fr-HMGB1. Notably, the beneficial effects of nonoxid-HMGB1 were attenuated by downregulation of SH3RF2. Furthermore, nonoxid-HMGB1 ameliorated cognitive impairment in rats post-TBI via SH3RF2. Altogether, our experimental results suggest that one of the promoting neurite outgrowth and regeneration mechanisms of nonoxid-HMGB1 is mediated through the upregulated expression of SH3RF2. Nonoxid-HMGB1 is an attractive therapeutic candidate for the treatment of TBI.

Bamboo Weaving Inspired Design of a Carbonaceous Electrode with Exceptionally High Volumetric Capacity.

A highly densified electrode material is desirable to achieve large volumetric capacity. However, pores acting as ion transport channels are critical for high utilization of active material. Achieving a balance between high volume density and pore utilization remains a challenge particularly for hollow materials. Herein, capillary force is employed to convert hollow fibers to a bamboo-weaving-like flexible electrode (BWFE), in which the shrinkage of hollow space results in high compactness of the electrode. The volume of the electrode can be decreased by 96% without sacrificing the gravimetric capacity. Importantly, the conductivity of BWFE after thermal treatment can reach up to 50,500 S/m which exceeds that for most other carbon materials. Detailed mechanical analysis reveals that, due to the strong interaction between nanoribbons, Young's modulus of the electrode increases by 105 times. After SnO2 active materials is impregnated, the BWFE/SnO2 electrode exhibits an exceptionally ultrahigh volumetric capacity of 2000 mAh/cm3.

l-Theanine improves emulsification stability and antioxidant capacity of diacylglycerol by hydrophobic binding ß-lactoglobulin as emulsion surface stabilizer.

Diacylglycerol (DAG) is commonly used as fat substitute in food manufacture due to its functional properties, but DAG has poor emulsification and oxidation stability, which limits its wide application in food industry. In this work, fluorescence quenching data and thermodynamic parameters were analyzed to investigate the interaction mechanism between l-theanine (L-Th) and ß-lactoglobulin (ß-LG). DAG emulsion was prepared by using ß-lactoglobulin-theanine (ß-LG-Th) as surface stabilizer, and its emulsification and oxidation stability were evaluated. The results showed that the hydrophobic interaction played an important role on the conjugate of ß-LG and L-Th due to the negative values for ΔG, positive values for ΔH and ΔS at pH 4.0, pH 6.0 and pH 8.0. The DAG has been better embedded by using ß-LG-Th as surface stabilizer, and the droplet size was about 0.2 µm to 1.5 µm when the pH was 6.0, the ratio of L-Th to ß-LG was 1:1. ß-LG-Th as surface stabilizer for DAG can increase the ζ-potential and emulsion index, make the emulsion droplet size distribution more uniform. The l-theanine was better to be used to improve the emulsification stability and antioxidant capacity of DAG by binding ß-LG as surface stabilizer.

A template oriented one-dimensional Schiff-base polymer: towards flexible nitrogen-enriched carbonaceous electrodes with ultrahigh electrochemical capacity.

Lithium-ion capacitors (LICs) have attracted much attention considering their efficient combination of high energy density and high-power density. However, to meet the increasing requirements of energy storage devices and the flexible portable electronic equipment, it is still challenging to develop flexible LIC anodes with high specific capacity and excellent rate capability. Herein, we propose a delicate bottom-up strategy to integrate unique Schiff-base-type polymers into desirable one-dimensional (1D) polymeric structures. A secondary-polymerization-induced template-oriented synthesis approach realizes the 1D integration of Schiff-base porous organic polymers with appealing characteristics of a high nitrogen-doping level and developed pore channels, and a further thermalization yields flexible nitrogen-enriched carbon nanofibers with high specific capacity and fast ion transport. Remarkably, when used as the flexible anode in LICs, the NPCNF//AC LIC demonstrates a high energy density of 154 W h kg-1 at 500 W kg-1 and a high power density of 12.5 kW kg-1 at 104 W h kg-1. This work may provide a new scenario for synthesizing 1D Schiff-base-type polymer derived nitrogen-enriched carbonaceous materials towards promising free-standing anodes in LICs.