1.
Front Microbiol
; 8: 1445, 2017.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28824576
RESUMO
This work investigates the pharmacodynamic effectiveness of cefquinome against environmental Escherichia coli mastitis infection, following an intramammary administration. We established the pharmacokinetic and pharmacodynamic (PK/PD) model in lactating mice. The PK/PD parameters were identified to achieve an antibacterial efficacy as indicated by PD activity, cytokine expression and PK/PD simulation. From our findings, given an 200 µg/gland dose once daily can achieve a considerable therapeutic effectiveness in experimental circumstance.