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1.
Opt Express ; 26(26): 34956-34964, 2018 Dec 24.
Artigo em Inglês | MEDLINE | ID: mdl-30650911

RESUMO

We demonstrate a flat optical lens based on plasmonic reflectarray metasurface, which consists of a planar array of hyperbolic-shaped aluminum (Al) nanoantenna separated from an Al ground plane by a SiO2 spacer. The gradual change in the width of the Al nanoantenna enables unique broadband (400-700 nm) to focus on the visible band because of its hyperbolic reflection-phase profile. The focal length of metalens is quickly decreased with the increase of wavelength in the short wavelength region (400-550 nm), compensating the chromatic aberration in traditional lenses. In long wavelength region (550-700 nm), the focal length has only a slight change, thereby minimizing chromatic aberration. Furthermore, the proposed metalens creates a small focal spot beyond diffraction limit, while maintaining high focusing efficiency. Our method of simple and anisotropic nanoantenna is used to realize wide phase tuning range offers a novel strategy to design braodband metalens, and our metalens has widespread applications in compact camera, telescope, and microscope.

2.
J Tongji Med Univ ; 14(3): 188-92, 1994.
Artigo em Inglês | MEDLINE | ID: mdl-7807608

RESUMO

Immunologically mediated aplastic anemia in mice were used as animal models to study the the curative effect of Zaizhang-I in term of the changes of two pathogenetic aspects in aplastic mice, namely the deficiency of hematopoietic stem cells and the disturbance of immunology. Our results demonstrated that in aplastic mice, after treatment by Zaizhang-I, the loss of mature hematopoietic cells (WBC, RBC, Plt) were reduced, and marrow cellular cytosis, and their clinical findings were improved, indicating a partial remission. The present data show that its curative mechanism lies in the action of promoting the recovery of colony forming unit-spleen (CFU-S) and reversing immunologically-induced plasma colony forming unit granulocyte/macrophage (CFU-GM) inhibitory activity. Natural killer cells activity (Nka) and interleukin-2, tumor necrosis factors (TNF) were also so examined to further understand the mechanism by which Zaizhang-I reverse plasma hematopoietic activity.


Assuntos
Anemia Aplástica/tratamento farmacológico , Medicamentos de Ervas Chinesas/uso terapêutico , Anemia Aplástica/imunologia , Animais , Medicamentos de Ervas Chinesas/farmacologia , Feminino , Células-Tronco Hematopoéticas/efeitos dos fármacos , Interleucina-2/metabolismo , Células Matadoras Naturais/imunologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos DBA , Distribuição Aleatória , Fator de Necrose Tumoral alfa/metabolismo
3.
J Tongji Med Univ ; 14(4): 224-6, 1994.
Artigo em Inglês | MEDLINE | ID: mdl-7760433

RESUMO

Effects of Zaizhang-I (ZZ-I) on the recovery of hemopoietic systems from radiation injury were investigated. Mice, irradiated with 6.0 Gy-rays, were injected i.p. once daily for 7 consecutive days with either ZZ-I or saline (0.01 ml/g body wt.). The experiments showed that ZZ-I significantly promoted the recovery of not only peripheral WBC, BMC, CFU-S and CFU-GM but also the abnormal femur micro-vessel system such as blood vessels and sinus ectasia, hyperemia and hemorrhage etc. These results suggest that ZZ-I could accelerate hemopoietic recovery from radiation injury in mice by stimulating hemopoietic stem cells and improving hemopoietic inductive microenvironment (HIM).


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Células-Tronco Hematopoéticas/efeitos dos fármacos , Lesões Experimentais por Radiação/tratamento farmacológico , Animais , Feminino , Camundongos , Camundongos Endogâmicos BALB C
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