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Bioorg Med Chem Lett
; 15(4): 863-7, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15686876
RESUMO
The protein structure guided design of a series of pyrazolo[1,5-a]pyrimidines with high potency for human cyclin-dependent kinase 2 (CDK2) is described. Some examples were shown to inhibit the growth of human colon tumour cells, were equipotent for CDK1 and were selective against GSK-3beta and other kinases.