Human health risk assessment of toxic heavy metals in summer crops and vegetables: a study in Ilam Province, Iran.

Purpose: The presence of toxic heavy metals (HMs) in agricultural crops can be considered as a noteworthy threat for consumers. The aim of this study was to assess the content of HMs (Pb, As, Cr, Cd, Co, Hg, and Ag) and their potential health risk in summer crops and vegetables (watermelon, cantaloupe, cucumber, melon, tomato, onion, potato, raw and stewed vegetables) in Ilam province, Iran. Methods: Totally, 31 crop samples were collected from local farms during the 2019 harvest season and the elements content were evaluated using inductively coupled plasma-mass spectrometry (ICP-MS). The non-carcinogenic health risk of HMs to the adults and children was estimated by Monte Carlo simulation method and target hazard quotients (THQs). Results: In general, the results showed that the concentration of Cr in the studied agricultural crops was higher than other HMs. As well as, the carcinogenic risk (CR) obtained for adults and children were more than the acceptable range for As. Also, CR for As in raw vegetable was the most ( 8.19E-1) and violated the threshold risk limit. The total carcinogenic risk of HMs in children was higher than that in adults. Conclusion: These results suggest that the agricultural crops were not safe for human consumption with potential risks associated. Due to the possible health effects of such products consumption, proper action should be taken to avoid chronic exposure, prevention of further pollution and consequent adverse health implications.

Cerebellar granule cell migration and folia development require Mllt11/Af1q/Tcf7c.

The organization of neurons into distinct layers, known as lamination, is a common feature of the nervous system. This process, which arises from the direct coupling of neurogenesis and neuronal migration, plays a crucial role in the development of the cerebellum, a structure exhibiting a distinct folding cytoarchitecture with cells arranged in discrete layers. Disruptions to neuronal migration can lead to various neurodevelopmental disorders, highlighting the significance of understanding the molecular regulation of lamination. We report a role Mllt11/Af1q/Tcf7c (myeloid/lymphoid or mixed-lineage leukemia; translocated to chromosome 11/All1 fused gene from chromosome 1q, also known as Mllt11 transcriptional cofactor 7; henceforth referred to Mllt11) in the migration of cerebellar granule cells (GCs). We now show that Mllt11 plays a role in both the tangential and radial migration of GCs. Loss of Mllt11 led to an accumulation of GC precursors in the rhombic lip region and a reduction in the number of GCs successfully populating developing folia. Consequently, this results in smaller folia and an overall reduction in cerebellar size. Furthermore, analysis of the anchoring centers reveals disruptions in the perinatal folia cytoarchitecture, including alterations in the Bergmann glia fiber orientation and reduced infolding of the Purkinje cell plate. Lastly, we demonstrate that Mllt11 interacts with non-muscle myosin IIB (NMIIB) and Mllt11 loss-reduced NMIIB expression. We propose that the dysregulation of NMIIB underlies altered GC migratory behavior. Taken together, the findings reported herein demonstrate a role for Mllt11 in regulating neuronal migration within the developing cerebellum, which is necessary for its proper neuroanatomical organization.

Extensive sorption of Amoxicillin by highly efficient carbon-based adsorbent from palm kernel: Artificial neural network modeling.

In the present study, a new sorbent was fabricated from Palm kernel (PK) by dry thermochemical activation with NaOH and characterized by FTIR, X-ray diffraction, FE-SEM and BET, which was used for the Amoxicillin (AMX) sorption from aqueous solution. The influence of effective parameters such as pH, reaction time, adsorbent dosage, AMX concentration and ionic strength on the sorption efficacy of AMX removal were evaluated. The main functional groups on the surface of the magnetic activated carbon of Palm Kernel (MA-PK) were C-C, C-O, C[bond, double bond]O and hydroxyl groups. The specific surface of char, activated carbon Palm Kernel (AC-PK) and MA-PK were 4.3, 1648.8 and 1852.4 m2/g, respectively. The highest sorption of AMX (400 mg/L) was obtained by using 1 g/L of sorbent at solution pH of 5 after 60 min contact time, which corresponding to 98.77%. Non-linear and linear models of isotherms and kinetics models were studied. The data fitted well with Hill isotherm (R2 = 0.987) and calculated maximum sorption capacity were 719.07 and 512.27 mg/g from Hill and Langmuir, respectively. A study of kinetics shows that the adsorption of AMX follows the Elovich model with R2 = 0.9998. Based on the artificial neural network (ANN) modeling, the MA-PK dosage and contact time showed the most important parameters in the removal of AMX with relative importance of 36.5 and 25.7%, respectively. Lastly, the fabricated MA-PK was successfully used to remove the AMX from hospital wastewater.

Life cycle assessment of Tehran Municipal solid waste during the COVID-19 pandemic and environmental impacts prediction using machine learning.

Life cycle assessment and machine learning were combined to find the best option for Tehran's waste management for future pandemics. The ReCipe results showed the waste's destructive effects after COVID-19 were greater than before due to waste composition changes. Plastic waste has changed from 7.5 to 11%. Environmental burdens of scenarios were Sc-1 (increase composting to 50%) > Sc-3 > Sc-4 > Sc-b2 > Sc-5 > Sc-2 (increase recycling from 9 to 20%). The artificial neural network and gradient-boosted regression tree could predict environmental impacts with high R2. Based on the results, the environmental burdens of solid waste after COVID-19 should be investigated.

Forward propagation dropout in deep neural networks using Jensen-Shannon and random forest feature importance ranking.

Dropout is a mechanism to prevent deep neural networks from overfitting and improving their generalization. Random dropout is the simplest method, where nodes are randomly terminated at each step of the training phase, which may lead to network accuracy reduction. In dynamic dropout, the importance of each node and its impact on the network performance is calculated, and the important nodes do not participate in the dropout. But the problem is that the importance of the nodes is not calculated consistently. A node may be considered less important and be dropped in one training epoch and on a batch of data before entering the next epoch, in which it may be an important node. On the other hand, calculating the importance of each unit in every training step is costly. In the proposed method, using random forest and Jensen-Shannon divergence, the importance of each node is calculated once. Then, in the forward propagation steps, the importance of the nodes is propagated and used in the dropout mechanism. This method is evaluated and compared with some previously proposed dropout approaches using two different deep neural network architectures on the MNIST, NorB, CIFAR10, CIFAR100, SVHN, and ImageNet datasets. The results suggest that the proposed method has better accuracy with fewer nodes and better generalizability. Also, the evaluations show that the approach has comparable complexity with other approaches and its convergence time is low as compared with state-of-the-art methods.

Microplastics and mesoplastics as emerging contaminants in Tehran landfill soils: The distribution and induced-ecological risk.

Environmental pollution with microplastics (MPs) and mesoplastics (MEPs) and their potential risks to human health and ecosystem quality have aroused the concern of communities. Therefore, the pioneering study was conducted on Tehran landfill soil contamination with MPs and MEPs. 56 shallow and deep soil samples were collected from different landfill areas in the wet and dry seasons. The physical and chemical characteristics of MPs and MEPs were measured using a stereomicroscope and FTIR-ATR spectroscopy, respectively. The results showed that the average MP abundance in shallow and deep soil was 863 ± 681 and 225 ± 138 particles/kg soil, and for MEPs, it was 29.8 ± 6.4 and 18.1 ± 8.3 particles/kgsoil. The low-density plastic particles were separated completely by flotation with H2O, NaCl, and ZnCl2 solutions, but PVC was only separated by 90%. Over 90% of MPs and MEPs were LDPE, PP, and PS polymers, explained by their widespread applications in single-use products and their consumption in Iran. Films, white and black, and 0.1-0.5 mm were the dominant shapes, colors, and sizes of MPs, respectively. The prevailing MEPs were film-shaped and in white and yellow colors, with a size of 0.5-1.0 cm. Canonical correlation analysis indicated that total organic matter and moisture were highly correlated with MP shapes. The calculated polymer hazard index values have a wide range at different sampling points, and this index yielded hazard levels III-IV and II-IV for MPs and MEPs, respectively, while according to the pollution load index category, the hazard level of MPs and MEPs was I-II and I. The potential ecological risk index from combined polymers has been estimated to be of minor to extreme danger for MPs and of minor risk for MEPs. Our findings provided baseline data on MPs contamination in Tehran landfill soil and its associated ecological risk, which aids policymakers in implementing risk-reduction measures.

A Rare Case of Humerus Synovial Sarcoma Originated from Bone Tissue: Case Report.

Synovial sarcoma (SS) is a malignant mesenchymal neoplasm that is relatively common in the distal extremities. Primary SS of bone is an extremely rare finding. Here in this report, we present a 44-year-old male patient referred with bone and later bone fracture that was finally diagnosed with primary SS of thumerus. So far, 13 documented cases of primary SS of the bone have been reported. The current case is the second known case of primary SS of humerus. Our case was treated with both neoadjuvant and adjuvant chemotherapies associated with surgical tumor removal and prosthesis implantation. Follow-up of the case demonstrated significant remission but with late metastasis and subsequent advanced chemotherapy regimens.

High-performance Mach-Zehnder modulator using tailored plasma dispersion effects in an ITO/graphene-based waveguide.

A high-performance electro-optic Mach-Zehnder modulator (MZM) with outstanding characteristics is proposed. The MZM is in a push-pull configuration that is constructed using an ITO/graphene-based silicon waveguide. A novel idea for engineering of the plasma dispersion effect in an ITO/graphene-based waveguide is proposed so that the modulation characteristics of the MZM are highly improved. Plasma dispersion effects of ITO and graphene layers are tailored in such a way that a large difference between real parts of guided mode effective index of the two arms is achieved while their corresponding imaginary parts are equal. As a result, a very low [Formula: see text] of [Formula: see text] is achieved. To the best of our knowledge, this is one of the lowest [Formula: see text] reported for an electro-optic modulator. In addition, the proposed modulator exhibits a very high extinction ratio of more than 30 dB, low insertion loss of 2.8 dB and energy consumption of as low as 10 fJ/bit, which are all promising for optical communication and processing systems.

Interband plasmon-enhanced optical absorption of DNA nucleobases through the graphene nanopore.

We propose a novel, to the best of our knowledge, plasmonic-based methodology for the purpose of fast DNA sequencing. The interband surface plasmon resonance and field-enhancement properties of graphene nanopore in the presence of the DNA nucleobases are investigated using a hybrid quantum/classical method (HQCM), which employs time-dependent density functional theory and a quasistatic finite difference time domain approach. In the strong plasmonic-molecular coupling regime where the plasmon and DNA absorption frequencies are degenerated, the optical response of DNA molecule in the vicinity of the nanopore is enhanced. In contrast, when the plasmon and nucleobases resonances are detuned the distinct peaks and broadening of the molecular resonances represent the inherent properties of the nucleobase. Due to the different optical properties of DNA nucleobases in the ultraviolet (UV) region of light, the signal corresponding to the replacement of nucleobases in a DNA block can be determined by considering the differential absorbance. Results show the promising capability of the present mechanism for practical DNA sequencing.

Utilizing thermally induced selective mode shaping for a high extinction ratio in-line fiber modulator/polarizer.

Light-matter interactions of guided modes strongly depend on mode shape. This Letter presents an ultrahigh extinction ratio (ER) polarizer/modulator at λ=1.55µm, enabled by selective mode reshaping for different orthogonal modes. This bi-function device benefits from a designed side-polished fiber (SPF) with a three-layer stack of graphene/VO2/PMMA overlay. Thermally induced insulator-metal transition (IMT) in VO2 via a graphene microheater leads to the polarization-selective mode shaping (PSMS), which is used to manipulate orthogonal modes separately. As a result, a TE modulator (TM-pass polarizer) with an ultrahigh ER=168.4dB/mm (175.1 dB/mm) and low insertion loss (IL) of IL=3.38dB/mm (0.34 dB/mm) is achieved.

Level of air BTEX in urban, rural and industrial regions of Bandar Abbas, Iran; indoor-outdoor relationships and probabilistic health risk assessment.

This study focused on the measurement of BTEX (benzene, toluene, ethylbenzene and xylene) concentrations in the air of various regions and indoor-outdoor environments in Bandar Abbas, Iran. Air samples were taken actively and analyzed by gas chromatography-mass spectrometry (GC-MS) during two one-month periods i.e., Feb 2020 (period I) and Sep/Oct 2020 (period II). The mean air temperature and the levels of all BTEX compounds were higher in period II. The highest total BTEX (t-BTEX) levels (median [min-max]) were found in the urban region (18.00 [5.21-67.24] µg m-3), followed by industrial region (7.00 [2.05-14.76] µg m-3) and rural region (2.81 [ND-7.38] µg m-3). The significant positive correlations between all BTEX compounds and T/B ratio >1 indicated the vehicular traffic as the main source of emission. At 95th percentile probability, the non-cancer risk of t-BTEX in urban region was only less than one order of magnitude below the threshold level of unity (1.91E-01) and the cancer risk of benzene exceeded the recommended level of 1.0E-06 by U.S. EPA in urban (7.69E-06) and industrial (2.97E-06) regions. It was found that the indoor/outdoor ratio of BTEX concentration in beauty salon and hospital was greater than 1. Overall, the current levels of BTEX in the ambient air of study area, especially near urban roadside and in some indoor environments, should not be overlooked and appropriate mitigation actions should be undertaken.

Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation.

Cranial irradiation (IR) is an effective adjuvant therapy in the treatment of childhood brain tumors but results in long-lasting cognitive deficits associated with impaired neurogenesis, as evidenced in rodent models. Metformin has been shown to expand the endogenous neural stem cell (NSC) pool and promote neurogenesis under physiological conditions and in response to neonatal brain injury, suggesting a potential role in neurorepair. Here, we assess whether metformin pretreatment, a clinically feasible treatment for children receiving cranial IR, promotes neurorepair in a mouse cranial IR model. Using immunofluorescence and the in vitro neurosphere assay, we show that NSCs are depleted by cranial IR but spontaneously recover, although deficits to proliferative neuroblasts persist. Metformin pretreatment enhances the recovery of neurogenesis, attenuates the microglial response, and promotes recovery of long-term olfactory memory. These findings indicate that metformin is a promising candidate for further preclinical and clinical investigations of neurorepair in childhood brain injuries.

Recovery of the lumbar multifidus muscle size in chronic low back pain patients by strengthening hip abductors: A randomized clinical trial.

INTRODUCTION: Decrease in cross-sectional thickness of lumbar multifidus (MF) muscles during prolonged low back pain episodes commonly occurs. Restoration of the MF muscle size can be an effective way of treating chronic low back pain (CLBP) patients. Traditionally, clinicians apply muscle stabilization exercises for these patients. Recent studies support the need for active strengthening exercises for treatment of the CLBP patients. OBJECTIVE: The MF muscles provide lumbar stability, and therefore we hypothesized that strengthening of these muscles can be more effective than the MF muscle stabilization exercises in restoration of the muscle size. DESIGN: Study design was a randomized allocation control trial with two groups of adult female CLBP patients (n = 12 each; age range of 20-45). Patients in the control group underwent stabilization exercises and the patients in the intervention group underwent the hip abductor strengthening exercises. SETTING: For all subjects of each group, the trials continued in 24 sessions distributed over 8 weeks and the MF muscles were measured in the beginning of the first session and one week after completion of the last session. MAIN OUTCOME MEASURES: Statistical significance (p-value) of the change in the average MF muscle thickness, pain, and disability scores along with for each group were estimated. RESULTS: Both regimens of exercises can significantly decrease the pain and disability: average pain and disability reductions of 46% (p-value of 0.001) and 33% (p-value of 0.02) via stabilization versus average pain and disability reductions of 65% (p-value of 0.001) and 59% (p-value of 0.001) via hip abductor strengthening. However, the hip abductor strengthening is the sole statistically significant exercise regimen (p-value of 0.014 vs 0.94) for increasing the MF muscle size. CONCLUSION: Replacement of the traditional stabilization exercises with the hip abductor strengthening exercises for effective treatment of female adults with CLBP is recommended.

Simultaneous monitoring of SARS-CoV-2, bacteria, and fungi in indoor air of hospital: a study on Hajar Hospital in Shahrekord, Iran.

The novel SARS-CoV-2 outbreak was declared as pandemic by the World Health Organization (WHO) on March 11, 2020. Understanding the airborne route of SARS-CoV-2 transmission is essential for infection prevention and control. In this study, a total of 107 indoor air samples (45 SARS-CoV-2, 62 bacteria, and fungi) were collected from different wards of the Hajar Hospital in Shahrekord, Iran. Simultaneously, bacterial and fungal samples were also collected from the ambient air of hospital yard. Overall, 6 positive air samples were detected in the infectious 1 and infectious 2 wards, intensive care unit (ICU), computed tomography (CT) scan, respiratory patients' clinic, and personal protective equipment (PPE) room. Also, airborne bacteria and fungi were simultaneously detected in the various wards of the hospital with concentrations ranging from 14 to 106 CFU m-3 and 18 to 141 CFU m-3, respectively. The highest mean concentrations of bacteria and fungi were observed in respiratory patients' clinics and ICU wards, respectively. Significant correlation (p < 0.05) was found between airborne bacterial concentration and the presence of SARS-CoV-2, while no significant correlation was found between fungi concentration and the virus presence. This study provided an additional evidence about the presence of SARS-CoV-2 in the indoor air of a hospital that admitted COVID-19 patients. Moreover, it was revealed that the monitoring of microbial quality of indoor air in such hospitals is very important, especially during the COVID-19 pandemic, for controlling the nosocomial infections.

Heavy metal pollution of road dust in a city and its highly polluted suburb; quantitative source apportionment and source-specific ecological and health risk assessment.

Sources of heavy metals (As, Cd, Co, Cr, Cu, Mn, Ni, Pb and Zn) in the road dust of Bandar Abbas city, Iran, and its west suburb were apportioned and the related source-specific ecological and health risks were assessed. The level of heavy metal pollution and the related ecological risk for suburban road dust (suburban RD) were far higher than those of urban RD. Accordingly, probabilistic health risk assessment showed no significant health risk in urban region but significant health risk in the suburb, especially for As with cancer risk above 10-4. Source apportionment using positive matrix factorization (PMF) identified lithogenic source (45.9%) and traffic emission (47.6%) as the main sources of heavy metals in urban and suburban regions, respectively. However, the industrial/construction activities showed the main contribution in ecological risk in both regions. On the other hand, the health risks in urban and suburban regions were mainly attributed to lithogenic source (49.7% for non-cancer risk and 36.8% of cancer risk) and traffic emission (69.4% of non-cancer risk and 46.6% of cancer risk), respectively. The sensitivity analysis showed that the Pb and As originated from traffic emission had the most impact on the non-cancer and cancer risks, respectively, in the suburb. Therefore, this study highlighted the concern about traffic emission as a critical heavy metal source in the road dust of Bandar Abbas suburb.

Graphene-based mid-infrared plasmonic isolator with multimode interferometer.

This Letter presents an extremely compact graphene-based plasmonic isolator with a two-port multimode interference (MMI) structure. The proposed structure utilizes the non-reciprocal phase shift effect to provide optical isolation. A new approach is used for MMI-based isolator design in terms of mth overall self-imaging. The influence of the device geometries and m parameter on the isolation ratio (ISR), insertion loss, operation bandwidth (BW), and required magnetic field strength B and its appropriate direction is investigated. The device has an ultra-small footprint compared to the operating wavelength of λ=8µm with high ISR. An MMI isolator with a size of 0.5µm×4.02µm (≈λ2/32) and ISR=18.35dB and an MMI isolator with a size of 0.7µm×7.44µm (≈λ2/12) with ISR=27.1dB are achieved. Moreover, the non-reciprocal MMI shows ultra-wide 20 dB isolation BW of 0.75-2.34 THz.

Mid-infrared hybrid Si/VO2 modulator electrically driven by graphene electrodes.

Silicon photonic platforms are of significant interest for a variety of applications that operate in the mid-infrared regime. However, the realization of efficient mid-IR modulators, key components in any integrated optics platform, is still a challenging topic. Here, an ultra-compact high-speed hybrid Si/VO2 modulator operating at a mid-IR wavelength of 3.8 µm is presented. Electrical properties of graphene are employed to achieve a reversible insulating-metal phase transition in VO2 by electrical actuation. The thermal characteristics of graphene are employed to improve the response time of the VO2 phase transition through speed up heating and dissipation processes, thus enhancing the modulation speed. Optical and thermal simulations show an extinction ratio of 4.4 dB/µm, an insertion loss of 0.1 dB/µm, and high modulation speed of 23 ns. A larger modulation depth as high as 10 dB/µm can be achieved at the cost of lower modulation speed.

Favorable outcome of extended curettage for the treatment of unifocal chronic sclerosing osteomyelitis of clavicle: a case series.

BACKGROUND: Chronic sclerosing osteomyelitis (CSO) of the clavicle, especially its unifocal subset, is scarcely reported, and little is known about its characteristic features and treatment. We aim to describe the characteristic features and outcome of treatment in a series of patients with unifocal CSO of the clavicle. MATERIALS AND METHODS: In a retrospective study, we identified 6 patients with a diagnosis of unifocal CSO of the clavicle. All patients underwent a core needle biopsy, and histologic examination confirmed the diagnosis. Laboratory investigations included the white blood cell count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and bacteriologic culture. We used plain radiographs, computed tomography scanning, and magnetic resonance imaging for the radiologic evaluation. RESULTS: The median age of the patients was 16.5 years (range, 10-29 years). The ESR and CRP level were elevated in 5 cases. The bacterial culture results were negative in all cases. Sclerosis was the main radiologic symptom. Other radiologic features such as bone expansion, cystic change, periosteal reaction, cortex destruction, and soft-tissue edema could accompany sclerosis. Anti-inflammatory medications temporarily and slightly reduced the symptoms. Four patients underwent extended curettage, in whom the clinical, radiologic, and laboratory symptoms considerably subsided. In the 2 patients who did not agree to undergo surgical intervention, the clinical and radiologic symptoms fluctuated at the follow-up visits. CONCLUSION: Unifocal CSO of the clavicle is associated with negative bacterial culture results, but the ESR and CRP level are frequently elevated. The symptoms fluctuate if not adequately treated. Extended curettage could be regarded as the treatment of choice.