Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review.

Cannabis sativa L. (Cannabis) and its bioactive compounds, including cannabinoids and non-cannabinoids, have been extensively studied for their biological effects in recent decades. Cannabidiol (CBD), a major non-intoxicating cannabinoid in Cannabis, has emerged as a promising intervention for cancer research. The purpose of this review is to provide insights into the relationship between CBD and cancer based on recent research findings. The anticancer effects of CBD are mainly mediated via its interaction with the endocannabinoid system, resulting in the alleviation of pain and the promotion of immune regulation. Published reviews have focused on the applications of CBD in cancer pain management and the possible toxicological effects of its excessive consumption. In this review, we aim to summarize the mechanisms of action underlying the anticancer activities of CBD against several common cancers. Studies on the efficacy and mechanisms of CBD on cancer prevention and intervention in experimental models (i.e., cell culture- and animal-based assays) and human clinical studies are included in this review.

Effect of extrusion processing and addition of purple sweet potatoes on the structural properties and in vitro digestibility of extruded rice.

Recently, extruded rice as a functional ingredient has been a hot area of research in food processing. In this study, extruded rice with purple sweet potato (ERPSP) was prepared. Moreover, the effects of extrusion and added purple sweet potato on the structure and in vitro digestibility of extruded rice were studied via numerous detection methods, such as scanning electron microscopy (SEM), water absorption index (WAI), water solubility index (WSI), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). SEM results showed that there were numerous pits and bubbles in the extruded rice. In particular, compared with raw rice, the WAI and WSI of ERPSP was higher, and the thermal properties also changed noticeably. The results of XRD and FT-IR spectroscopy showed that the semicrystalline structure of extruded rice changed from A-type to A + V-type mixture, and the relative crystallinity of extruded rice changed accordingly. In addition, a significantly lower equilibrium hydrolysis (C∞) and kinetic constant (k) were observed in ERPSP. The novel rice product made from broken rice by extrusion processing and addition of the purple sweet potato exhibited improved structural properties and reduced digestibility, which increased the potential value and application of broken rice in the food industry.