1.
Eur J Paediatr Neurol
; 5 Suppl A: 175-7, 2001.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11588992
RESUMO
We used infantile neuronal ceroid lipofuscinosis (INCL), in which deterioration of the central nervous system is extremely rapid, to study constant release of an opioid for pains of central origin in a metabolic disease. The effect of a transdermal fentanyl patch was studied in five children with INCL. In two of them, measurements of 17 fentanyl serum concentrations and also visual analogue pain scale were obtained during a 15-day study period. Low doses of transdermal fentanyl usually provided good pain relief for the first two days, but not for the third day, of the three-day patch change interval. Pain relief of this type seems mandatory for pains mostly of central origin.
Assuntos
Analgésicos Opioides/administração & dosagem , Fentanila/administração & dosagem , Lipofuscinoses Ceroides Neuronais/complicações , Dor/tratamento farmacológico , Dor/etiologia , Administração Cutânea , Criança , Humanos , Resultado do Tratamento
2.
Cancer
; 39(3): 1280-8, 1977 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-912659