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Br J Nutr ; 131(11): 1844-1851, 2024 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-38443203

RESUMO

The primary goal of the investigation was to analyse the anti-inflammatory and antioxidant properties of Gamma-linolenic acid (GLA) on rats with indomethacin (IND)-induced gastric ulcers. Thirty rats were divided into five groups: Control, IND (50 mg/kg, p.o.), IND pretreated with GLA 100 mg/kg (p.o. for 14 d), IND pretreated with GLA 150 mg/kg (p.o. for 14 d) and IND pretreated with omeprazole (20 mg/kg, p.o. for 14 d). The stomach tissues were examined to calculate the ulcer index and pH and analyse biochemical markers (prostaglandin E2 (PGE2), cyclooxygenase 1 (COX1), TNF-1, IL-6 and intercellular adhesion molecule-1 (ICAM1)) and oxidative stress parameters (malondialdehyde: (MDA), superoxide dismutase (SOD), glutathione (GSH) and CAT (catalase)) as well as undergo histopathological assessment. GLA 100 and 150 mg/kg showed a protective effect against IND-induced gastric damage. It reduced levels of COX1, TNF-1, IL-6 and ICAM and increased PGE2 levels. GLA also normalised antioxidant function by modulating MDA, SOD, GSH and CAT. GLA intervention protects against IND-induced gastric ulcers by restoring oxidant/antioxidant balance and reducing inflammation.


Assuntos
Antioxidantes , Dinoprostona , Indometacina , Estresse Oxidativo , Ratos Wistar , Úlcera Gástrica , Ácido gama-Linolênico , Animais , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/prevenção & controle , Úlcera Gástrica/tratamento farmacológico , Indometacina/efeitos adversos , Antioxidantes/farmacologia , Ratos , Estresse Oxidativo/efeitos dos fármacos , Ácido gama-Linolênico/farmacologia , Masculino , Dinoprostona/metabolismo , Mucosa Gástrica/efeitos dos fármacos , Mucosa Gástrica/patologia , Mucosa Gástrica/metabolismo , Interleucina-6/metabolismo , Molécula 1 de Adesão Intercelular/metabolismo , Superóxido Dismutase/metabolismo , Antiulcerosos/farmacologia , Antiulcerosos/uso terapêutico , Glutationa/metabolismo , Fator de Necrose Tumoral alfa/metabolismo , Anti-Inflamatórios/farmacologia , Ciclo-Oxigenase 1/metabolismo , Malondialdeído/metabolismo , Omeprazol/farmacologia
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