[Study on induction of ginsenosides on HL-60 cell apoptosis].

OBJECTIVE: To observe whether the Ginsenosides (GS) could induce HL-60 cell line apoptosis from promyelocytic leukemia. METHODS: HL-60 cells were treated with GS of various concentration to observe the effect of GS on cell morphological change, the DNA content change by flow cytometry, DNA ladder by electrophoresis, and apoptosis rate by Annexin V-FITC test of the cells. RESULTS: GS could inhibit the growth of HL-60 cells and induce cell apoptosis in a certain scope of dose and reacting time. CONCLUSION: GS could specifically induce apoptosis in HL-60 cells, which provides an experimental basis for treatment of leukemia with GS as an supplemntary agent of chemotherapy.