[The influence of L-dopa and of thymus fraction on the survival rate of whole-body-irradiated mice]. / Der Einfluss von L-Dopa und Thymusfraktion auf die Uberlebensrate ganzkörperbestrahlter Mäuse.

The survival rate of mice with exposure of the whole body (700 cGy) was hardly changed by one dose as well as several doses of the phosphodiesterase inhibitor Amantadine and the interferon inductor measles vaccine. However, the survival rates were increased by one administration of L-dopa or by the long-term therapy using L-dopa at 700 and 900 cGy. The survival rates were also increased at 700 and 900 cGy if, after the exposure, thymus factor isolated from calf thymus was three times applied to the animals. The increased survival rates gained by using L-dopa and thymus factor are correlated with the determined leukocyte values.

[Age-related changes of cAMP and prostaglandin content in the brain and lymphocytes of spontaneously tumor-producing C3H mice]. / Altersbedingte Veränderungen des cAMP-und Prostaglandingehaltes im Gehirn und in den Lymphozyten von spontan mammakarzinombildenden C3H-Mäusen.

Age caused concurrent changes in the activation of the adenylate-cyclase activity by dopamine in the diencephalon and the stimulation of the basal level of cAMP by isoproterenol in the lymphocytes were demonstrated in the spontaneously tumor producing C3H mice. These changes may be related to the occurrence of tumors in these animals. The above-mentioned changes in the cAMP system were not found in AB mice. By treating the adult C3H mice with substances which increase the cAMP level, it was possible to achieve a renewed stimulation of the cAMP system as seen in young mice. With this treatment the spontaneous tumor-induction rate was also reduced. In the adenocarcinomas of the C3H mice a decrease in the level of prostaglandin E and an increase in the level of prostaglandin F2 alpha was observed.

[Changes in interferon and thymus factor levels as well as in lymphocyte populations in patients with mammary carcinoma (author's transl)]. / Veränderungen des Interferon- und Thymusfaktorspiegels sowie der Lymphozytenpopulationen bei Mammakarzinompatienten.

Changes in interferon and thymus factor as well as in cAMP levels and lymphocyte populations were recorded from patients with mammary carcinoma. They were equally recordable from those in whom no clinical tumour had been detectable at the time of postsurgical examinations as well as from patients with metastases distant from the primary tumour. The possibility for centralised disorder of immunological tumour cell defence in carcinoma patients is discussed.