[Effects of neurectomy of the tympanic plexus on secretion of the parotid gland in man. Histopathological, histochemical and clinical study (author's transl)]. / Effets de la neurectomie du plexus tympanique sur la sécrétion de la glande parotide chez l'homme.

This study involved five patients suffering from bilateral chronic parotiditis and then with a persistent unilateral fistula of the parotid gland. Two types of parotid biopsy were examined: the first taken during surgery and the second six months later. All of the specimens underwent histopathological and histochemical investigations. Definitive degeneration and atrophic type changes were seen in all the parotid fragments removed six months after selective neurectomy of the tympanic plexus. Six months after surgery, all of the patients were cured.

Effect of tympanic neurectomy on human parotid salivary gland. Histopathologic, Histochemical, and Clinical Study.

Five patients with bilateral chronic recurrent parotiditis and ten patients with unilateral persistent paratoid gland fistulas underwent tympanic neurectomies. Two biopsy specimens from the diseased gland were examined. The first biopsy specimen was taken at the time of operation, while the second one was taken six months later. All specimens were subjected to both histopathologic and histochemical investigations. Definite degenerative and atrophic changes occured in all parotid gland specimens taken six months after selective tympanic neurectomy. All patients were completely cured at about that time. This supported the practical indication of the selective tympanic neurectomy for treating certain benign disorders or diseases of the parotid gland that require persistent arrest of the function of its secretory units.

The effect of oestrogen on the nasal respiratory mucosa. An experimental histopathological and histochemical study.

An experimental histopathological and histochemical work carried out in thirty guinea-pigs of an average weight of 475 gm. receiving oestrogen in the form of ethynyl oestradiol in a dose of 10 microgram/animal/day and aiming at a study of the effects of oestrogen on the respiratory nasal mucosa. The histopathalogical lesions of the respiratory nasal mucosa were in the form of squamous metaplasia and spongiosis of the lining epithelium, with oedema of the underlying corium, glandular hyperplasia submucosal cellular infiltration, increased vascularity and some vascular changes in the form of endothelial proliferation with intimal thickening. Histochemical enzymatic alterations were in the form of increased succinic dehydrogenase activity in the epithelium as well as in the hyperplastic submucous glands, intensified reaction of the acid phosphatase in the cells of the corium, and the appearance of alkaline phosphatase activity in the apical parts of the cells lining the glands, indicating increased secretory activity. All the changes obtained in the histopathological and histochemical studies can be attributed to hormonal stimulation of the nasal mucosa.

PIP: The histopathological and histochemical effects of 10 mcg/day of eth inyl estradiol (EE) on the nasal respiratory mucosa were studied in 30 female guinea pigs. Histopathological changes observed after treatment were: 1) squamous metaplasia, 2) spongcosis and edema of the corium, 3) glandular hyperplasia, 4) cellular infiltrations, 5) increased vascularity, and 6) vascular changes in the form of endothelial proliferation with intimal thickening. The observed histochemical changes were: 1) increased succinic dehydrogenase activity in the epithelium and hyperplastic submucous glands, 2) an intensified reaction of acid phosphatase activity in the cells of the corium, and 3) alkaline phosphatase activity in the apical areas of the cells lining the glands. All of the observed changes are attributed to the stimulation of the nasal mucosa by EE.