Sustainable, Green, and Continuous Synthesis of Fivefold Palladium Nanorods Using l-Ascorbic Acid in a Segmented Millifluidic Flow Reactor.

Pd nanorods (PdNRs) have recently come to attention due to their wide array of applications. The green synthesis of PdNR with a relatively high yield and high aspect ratio is challenging. A continuous millifluidic flow reactor (CMFR) has been explored to precisely control mass and heat transfer as well as mixing in the PdNR synthesis processes. CMFRs demonstrate a few drawbacks, such as the presence of parabolic velocity profile in the laminar flow of the reaction solution, causing uneven axial residence time distribution. The CMFRs are likely to show irreversible fouling, which may cause the product quality to deteriorate or result in the channel being clogged. These shortcomings can be avoided or minimized using a segmented millifluidic flow reactor (SMFR) that consists of the solution forming a train of individual segments in another inert medium. This study explores the use of a sustainable reducing agent (l-ascorbic acid) in the presence of potassium bromide (KBr) as the capping agent and poly(vinyl pyrrolidone) (PVP) as the stabilizing agent for PdNR synthesis in an SMFR employing compartmentalized flow of a reaction solution, in which liquid segments consisting of a reaction solution will be immersed in the steam generated by boiling of the solvent water. The effect of reaction parameters such as reagent concentration has been studied on the size and morphology of synthesized Pd nanostructures. A kinetic study has been conducted to calculate the rate of reduction that can be used as a quantitative measure for manipulation of the type and relative concentration of initially formed seeds. It has been shown that the initial reduction rate during the first 45 min of residence time of the millifluidic reactor is about 66% faster compared to the rest of the reaction. A filtration procedure has been utilized to separate Pd nanostructures other than nanorods synthesized in the SMFR.

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures.

The significance of silver nanostructures has been growing considerably, thanks to their ubiquitous presence in numerous applications, including but not limited to renewable energy, electronics, biosensors, wastewater treatment, medicine, and clinical equipment. The properties of silver nanostructures, such as size, size distribution, and morphology, are strongly dependent on synthesis process conditions such as the process type, equipment type, reagent type, precursor concentration, temperature, process duration, and pH. Physical and chemical methods have been among the most common methods to synthesize silver nanostructures; however, they possess substantial disadvantages and short-comings, especially compared to green synthesis methods. On the contrary, the number of green synthesis techniques has been increasing during the last decade and they have emerged as alternative routes towards facile and effective synthesis of silver nanostructures with different morphologies. In this review, we have initially outlined the most common and popular chemical and physical methodologies and reviewed their advantages and disadvantages. Green synthesis methodologies are then discussed in detail and their advantages over chemical and physical methods have been noted. Recent studies are then reviewed in detail and the effects of essential reaction parameters, such as temperature, pH, precursor, and reagent concentration, on silver nanostructure size and morphology are discussed. Also, green synthesis techniques used for the synthesis of one-dimensional (1D) silver nanostructures have been reviewed, and the potential of alternative green reagents for their synthesis has been discussed. Furthermore, current challenges regarding the green synthesis of 1D silver nanostructures and future direction are outlined. To sum up, we aim to show the real potential of green nanotechnology towards the synthesis of silver nanostructures with various morphologies (especially 1D ones) and the possibility of altering current techniques towards more environmentally friendly, more energy-efficient, less hazardous, simpler, and cheaper procedures.

Engineering Tobacco Mosaic Virus and Its Virus-Like-Particles for Synthesis of Biotemplated Nanomaterials.

Biomolecules are increasingly attractive templates for the synthesis of functional nanomaterials. Chief among them is the plant tobacco mosaic virus (TMV) due to its high aspect ratio, narrow size distribution, diverse biochemical functionalities presented on the surface, and compatibility with a number of chemical conjugations. These properties are also easily manipulated by genetic modification to enable the synthesis of a range of metallic and non-metallic nanomaterials for diverse applications. This article reviews the characteristics of TMV and related viruses, and their virus-like particle (VLP) derivatives, and how these may be manipulated to extend their use and function. A focus of recent efforts has been on greater understanding and control of the self-assembly processes that drive biotemplate formation. How these features have been exploited in engineering applications such as, sensing, catalysis, and energy storage are briefly outlined. While control of VLP surface features is well-established, fewer tools exist to control VLP self-assembly, which limits efforts to control template uniformity and synthesis of certain templated nanomaterials. However, emerging advances in synthetic biology, machine learning, and other fields promise to accelerate efforts to control template uniformity and nanomaterial synthesis enabling more widescale industrial use of VLP-based biotemplates.

A rapid millifluidic synthesis of tunable polymer-protein nanoparticles.

Polymeric nanoparticles have drawn recent attention for their ability to enhance the efficacy of therapeutic proteins through reduced immunogenicity and extended circulation time. Though effective, most nanoparticle drug delivery systems are currently produced in batch processes that are limited in control parameters and scalability. To address these deficiencies, a millifluidic process was developed to encapsulate bovine serum albumin in poly(L-lysine)-grafted-poly(ethylene glycol) through an electrostatic self-assembly mechanism. The millifluidic process utilized ultrasonication to overcome the diffusional barriers to self-assembly in a laminar flow regime and produce a nanoparticle tunable by controlling the feed flow rate, tubing material, and ultrasonic power input. Nanoparticle diameters ranged from 13 to 300 nm with polydispersity index measurements ranging from 0.1 to 0.4. The copolymer fully encapsulated the protein in all system configurations and protected the encapsulated protein in the presence of proteases. Notably, the enzymatic activity of the millifluidic nanoparticles was both comparable to that of nanoparticles produced through the batch process and greater than that of the free protein, suggesting there is little difference in the self-assembly induced through the batch and millifluidic processes. This study presents the utility of millifluidics in the synthesis of polymer-protein nanoparticles and provides insight into the development of continuous processes for the production of nanoparticle drug delivery systems.