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1.
Front Oncol ; 11: 764758, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34868986

RESUMO

Metastatic prostate cancer remains a challenge for clinicians. Metastases involve mainly the bone compartment and can manifest as oligometastatic disease. In this setting, the role of metastasis-directed therapies (MDT) including surgery and/or stereotactic body radiotherapy is currently evaluated. Visceral metastases are less common and have very poor prognosis in mPC. Whether treating isolated visceral metastases such as liver metastases with MDT could increase the prognosis remains unknown. We report the management of a prostate cancer patient who progressed on androgen deprivation therapy with apparition of two liver metastases. We describe the feasibility of combining MDT with abiraterone acetate and prednisone in a patient with metastatic castration-resistant prostate cancer. MDT allowed the interruption of abiraterone acetate, preventing cumulative toxicity of this agent.

2.
BMJ Case Rep ; 13(6)2020 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-32522726

RESUMO

Immune checkpoint inhibitors (ICIs) improve significantly outcome of patients with advanced renal cancer. Although immune-related adverse events involve frequently skin, digestive tract, lung, liver and endocrine organs, haematological toxicities are rare. We describe the case of a patient with metastatic renal cancer who was treated with nivolumab. Eight courses of nivolumab were administered without any toxicity; brain metastases were then diagnosed and treated with stereotactic radiotherapy. As the extra-cranial disease was stable, the ninth course of nivolumab was administered 5 days after the end of radiotherapy. One week later, he presented with rectal and nasal bleeding in a context of severe thrombocytopenia (1000/mm3). High dose of steroids and intravenous immunoglobulin reversed slowly the thrombocytopenia. This case highlights the possibility of life-threatening thrombocytopenia with ICIs. Interestingly, the close time relation with radiotherapy highlights a potential interaction, warranting a close follow-up of patients in this situation.


Assuntos
Neoplasias Encefálicas , Carcinoma de Células Renais , Epistaxe , Hemorragia Gastrointestinal , Glucocorticoides/administração & dosagem , Imunoglobulinas Intravenosas/administração & dosagem , Neoplasias Renais , Neoplasias Pulmonares , Nivolumabe , Doenças Retais , Trombocitopenia , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/secundário , Neoplasias Encefálicas/terapia , Carcinoma de Células Renais/patologia , Carcinoma de Células Renais/fisiopatologia , Carcinoma de Células Renais/terapia , Epistaxe/diagnóstico , Epistaxe/etiologia , Hemorragia Gastrointestinal/diagnóstico , Hemorragia Gastrointestinal/etiologia , Humanos , Inibidores de Checkpoint Imunológico/administração & dosagem , Inibidores de Checkpoint Imunológico/efeitos adversos , Neoplasias Renais/patologia , Neoplasias Renais/fisiopatologia , Neoplasias Renais/terapia , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/secundário , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Nefrectomia/métodos , Nivolumabe/administração & dosagem , Nivolumabe/efeitos adversos , Radiocirurgia/métodos , Doenças Retais/diagnóstico , Doenças Retais/etiologia , Trombocitopenia/induzido quimicamente , Trombocitopenia/complicações , Trombocitopenia/diagnóstico , Resultado do Tratamento
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