[Native magnetic resonance tomography imaging of the Morris hepatoma (MH-7777A) in the rat]. / Native kernspintomographische Darstellung des Morris-Hepatoms (MH-7777A) der Ratte.

UNLABELLED: Goal of the study presented was to establish an oncological animal model for implantable and differentiated hepatoma in the rat and to evaluate imaging of the tumor induced using MRI. MATERIAL AND METHODS: 20 male buffalo rats underwent tumor cell implantation of 150,000 MH7777-A cells via laparotomy. After 12 days MRI was performed T1w SE, T2w TSE fs, TIRM) for tumor detection and measurement of size. Immediately there after all rats were killed and macroscopic and histological examination performed. Pathological findings were correlated with MRI. RESULTS: In 5 out of 20 animals no tumor was found. Mean size of the hepatomas in 15 animals was 3.1 mm (+/- 1.7 mm). On MRI 14 out of 15 tumors were detectable. Mean diameter in MRI was 2.7 mm (+/- 1.5 mm; 1-5 mm). T2w TSE was superior for tumor detection compared with the TIRM, while the best anatomic depiction was offered by T1w SE. CONCLUSIONS: The MH7777-A tumor model presents with a rate of 75% even with the small tumor cell amount of 150,000 cells. With MRI using T2 weighted sequences with fat saturation a detection of tumors with diameters of 1 mm is reliably possible in 93% of the cases.

Osteoid osteoma that occurred in a former fracture site.

Diagnosis of osteoid osteoma often is delayed, despite its high incidence, because of similarities in presenting symptoms with other pathologic entities. The current case report describes a posttraumatic osteoid osteoma. Three years after osteosynthesis of a distal tibial fracture an osteoid osteoma was diagnosed at the former fracture site. After excluding osteomyelitis as a possible diagnosis, the tumor was excised successfully. Based on current knowledge of the pathogenesis of osteoid osteoma, it is unlikely that the lesion observed in the patient was attributable to the previous fracture.

Polymyositis of the skeletal muscles as an extraintestinal complication in quiescent ulcerative colitis.

Myositis of the skeletal muscle is a rare complication of inflammatory bowel disease. We report about a 33-year-old woman with quiescent ulcerative colitis known since 1995. She had suffered from recurring fever and pain in the thighs for about 4 weeks. Electromyography of quadriceps and deltoid muscles revealed myopathic changes. Diagnosis of polymyositis was confirmed by magnetic resonance imaging indicating edematous changes in the distal extremity muscles. The symptoms rapidly responded to high doses of steroids. Review of the literature indicates only a few cases describing an association of ulcerative colitis and myositis, most of them during acute exacerbations of the disease. In contrast, the present patient was in remission. Diagnosis of myositis should be considered in inflammatory bowel disease patients complaining of myalgia or muscular weakness. Magnetic resonance imaging may show specific features and can be used in addition to laboratory investigations and muscle biopsy for diagnosis of polymyositis.

[Skeletal anomalies in nail-patella syndrome. Case report and overview]. / Skelettanomalien beim Nagel-Patella-Syndrom. Fallbericht und Ubersicht.

The nail-patella syndrome (NPS), also known as hereditary onychoosteodysplasia (HOOD), is a hereditary disorder with an autosomal dominant mode of inheritance involving nails, bones and other tissues. It is characterized by onchodysplasia of the finger nails (most prominent on the thumb and index finger) and V-shaped lunulae. Extraosseous manifestations include ocular (glaucoma, microcornea) and renal involvement (proteinuria, nephrotic syndrome). A variety of skeletal anomalies can be observed. We report a 59 year old male with NPS. In addition to dysplastic patellae and elbow joints and the pathognomonic posterior iliacal horns, he had involvement of humerus, radius, ulna. and finger bones, leading to early and painful degenerative changes. Furthermore, microproteinuria was noted. Early diagnosis of NPS is important to prevent early secondary arthrosis and severe renal damage.

[Experimental studies of the visualization of the vertebral body spongiosa by high-resolution computed tomography]. / Experimentelle Untersuchungen zur Darstellbarkeit von Wirbelkörperspongiosa in der hochauflösenden Computertomographie.

AIM: To show the accuracy and the lower limit of visualisation of cancellous bone in high-resolution computed tomography (HR-CT). METHODS: 18 native human lumbar vertebrae were placed in a water phantom and examined by HR-CT. The scans were compared with contact radiographs of correlating thin bone sections by morphologic criteria. RESULTS AND CONCLUSION: The measured lower limit of visualisation of cancellous bone structures is clearly worse than expected from the measurements of spatial resolution with standard phantoms used for HR-CT (0.6 versus 0.4 mm). True and exact imaging of normal cancellous bone cannot be achieved even by modern HR-CT. Noise creates structures mimicking cancellous bone.