RESUMO
The possibility of early diagnosis and intervention is radically changed by the advent of genetic testing. The recent report of the Nuffield Council on Bioethics is timely and helpful. I have suggested, that not only the severity of the disability indicated by genetic information, and the accuracy of the data, ought to govern the approach to the implementation of screening for genetic disorders. In addition, assessment of the value of the information to those involved should be considered. The efficacy of the available therapeutic measures, combined with the prognostic data are important indices of the value of the information. These measures fall into three categories and thus indicate that three different courses of intervention may be appropriate. Three approaches to diagnosis and intervention are then outlined, drawing on the experience of various clinical initiatives.
Assuntos
Ética Médica , Doenças Genéticas Inatas/diagnóstico , Engenharia Genética/legislação & jurisprudência , Testes Genéticos/legislação & jurisprudência , Adulto , Feminino , Doenças Genéticas Inatas/terapia , Melhoramento Genético , Saúde , Humanos , Recém-Nascido , Masculino , Triagem Neonatal/legislação & jurisprudência , Gravidez , Gestantes , Diagnóstico Pré-Natal , Prognóstico , Medição de Risco , Resultado do Tratamento , IncertezaRESUMO
1. Cardiovascular reflexes to intravenous adrenaline and histamine and to carotid occlusion were studied in the renal vasculature, and direct effects of noradrenaline and clinidoine were compared in renal and hindlimb vascular beds in anaesthetized cats. 2. Unlike its reported effects on cardiovascular reflexes in the hindlimbs, clonidine depressed all three reflexes in the kidneys. 3. Noradrenaline caused vasoconstriction when given directly into both renal and hindlimb circulartions, but clonidine produced vasoconstriction only in the hindlimb vascular bed. 4. These results suggest that alpha-adrenoceptors in the reanl vasculature may be different from those in the hindlimbs, and that the cardiovascular reflexes in these two areas are under different control.
