High affinity binding sites for basic fibroblast growth factor in rat hepatic plasma membranes.

The binding of [125I]-recombinant basic FGF (rec bFGF) to rat hepatic plasma membranes was investigated. [125I] rec bFGF bound to an apparent single class of high affinity binding sites (KD = 69 pM; Bmax = 9.61 fmoles/mg proteins). The absence of low affinity sites was confirmed by the inability of sulphated polysaccharides and heparinase to interfere with FGF binding. A good correlation existed between the ability of bovine pituitary-derived bFGF, rec bFGF and bovine brain-derived aFGF to displace [125I]rec bFGF from these binding sites and their in vitro potency on bovine aortic endothelial cell proliferation.

[Ttoal hip arthroplasty after arthrodesis (desarthrodesis)]. / Arthroplastie totale dans les hanches arthrodésées (désarthrodèses).

A report is given on 24 cases of desarthrodesis of the hip long after arthrodesis, in one case after 73 years, the patient being a woman of 84, and in several cases after 40 years. In all cases the results were satisfactory and recovery was excellent despite the long duration of the arthrodesis. Desarthrodesis is therefore a valuable operation which may be indicated in cases where position is poor or lumbalgia inhibits the function.

[Indications and possibilities of total prosthesis of the hip]. / Indications et possibilités des prothèses totales de la hanche

If all the non-traumatic coxopathies are considered, it can be said that there is practically no limit to the possibilities of operations for total prostheses fo the hip. In particular, all the technical problems posed by certain forms of coxopathy can be solved. Only grave deterioration in the general condition of the patient and non-tubercular infections constitute contra-indications. This is, of course, not new and is valid for all orthopaedic surgery. Only the future will show if this concept is true.