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Eur Ann Allergy Clin Immunol ; 52(2): 91-93, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31668055

RESUMO

Summary: Clindamycin is widely used in the prophylaxis and treatment of infections due to its broad spectrum of antimicrobial activity. Hypersensitivity to clindamycin seems to be not very common (less than 1% of drug-allergic reactions) and it mostly appears as delayed T-cell mediated. For the diagnosis, skin testing is considered to be highly sensitive and rather safe, but cutaneous and systemic reactions have been described. Provocation test is considered the gold standard. However, it includes the possibility of severe reactions. We reported two cases of delayed allergic reaction to clindamycin, confirmed with a positive lymphocyte transformation test, showing this in vitro test like a promising diagnostic method because of its usefulness and safety.


Assuntos
Alérgenos/imunologia , Clindamicina/imunologia , Hipersensibilidade Tardia/diagnóstico , Imunoensaio/métodos , Testes Cutâneos/métodos , Pele/patologia , Linfócitos T/imunologia , Adolescente , Transformação Celular Neoplásica , Hipersensibilidade a Drogas/diagnóstico , Feminino , Humanos , Ativação Linfocitária , Masculino , Pessoa de Meia-Idade
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