Real-world experience with anti-PD-1/PD-L1 monotherapy in patients with non-small cell lung cancer : A retrospective Austrian multicenter study.

OBJECTIVE: As real-world data regarding immunotherapy for non-small cell lung cancer are lacking for Austria, we conducted a retrospective study in six hospitals to present data from real-world practice. METHODS: Patients with metastatic non-small cell lung cancer were stratified into two groups, either patients with first-line pembrolizumab monotherapy (cohort 1) or patients with second-line nivolumab, pembrolizumab or atezolizumab monotherapy (cohort 2). Primary outcome measures were objective response rate and overall survival. A matched-pair analysis was performed to compare overall survival to patients from the Tyrolean Lung Cancer Project as a historical control group. RESULTS: In total, 89 patients were identified, 42 patients in cohort 1 and 47 patients in cohort 2. The objective response rates were 43.3% and 31.4%, respectively. The median overall survival was 17.0 months (95% CI 11.7-21.5 months) in cohort 1 and 18.7 months (95% CI 9.5-23.4 months) in cohort 2. Treatment-related adverse events grades 3 and 4 were reported in 11.2% of patients. The matched-pair analysis showed a median overall survival of 15.2 months (95% CI 7.6-20.4 months) for first-line pembrolizumab monotherapy compared to 9.8 months (95% CI 7.8-11.6 months) for the historical control (p = 0.43). In cohort 2, a median overall survival of 20.3 months (95% CI 6.9-26.2 months) for second-line immunotherapy compared to 5.4 months (95% CI 3.2-11.7 months) for the historical control (p = 0.18) was shown. CONCLUSION: The results are comparable with other real-world studies and, when matched to historical controls, support the improvement in outcomes made possible by these agents.

[Suicide reporting in German print and online media for adolescents in Austria and possible effects on suicide prevalence]. / Darstellung von Suizidalität in deutschsprachigen Jugendmedien in Oesterreich und ihr Einfluss auf die Suizidprävalenz.

OBJECTIVE: We analyzed the quality of suicide reporting in youth magazines and assessed potential copycat effects following media reports on suicide. METHOD: We obtained suicide-related articles from five Austrian and German youth magazines published between 1996 and 2008. Reported sex, suicide (attempt) methods, suicide motives, the portrayal of suicide in a positive or negative light, accusations of blame and consistency with media recommendations for the reporting of suicide were analysed using qualitative content analysis. The suicide frequency among adolescents in Austria was compared 2 weeks before and after the publication of reports on suicide and suicide attempts. RESULTS: 59 articles were identified, most of which had been published in the magazine Bravo. There was an overrepresentation of suicide among girls and an underrepresentation of attempted suicide. The frequency of specific suicide and suicide attempt methods was consistent with epidemiological distributions of suicide methods. Fall from height was most frequently described for girls and hanging for boys. Regarding motives for suicide, factors like psychiatric diseases were underrepresented. Girls who died by suicide were often positively described in articles, but boys were more often negatively described. Parents were frequently blamed as being guilty of their child's suicidal behaviour, in particular when reporting on suicide attempts. Photos, suicide notes and details concerning method were frequently described. There was no indication of a Werther effect following reporting. CONCLUSIONS: The identified discrepancies between epidemiologic data regarding suicidal behaviour in adolescents and media reporting in youth media constitutes an important basis for suicide prevention in the community.

Colecistite enfisemtosa: uma entidade clínica bem definida? / Emphysematous cholecystitis: a distinct clinical entity

Colecistite enfisematosa é uma afecçäo pouco freqüente, com uma alta taxa de mortalidade e que freqüentemente é confundida com colecistite aguda. Através do relato de um caso e uma breve revisäo da literatura, mostramos alguns aspectos particulares desta doença. Além disso, comparamos ambas patologías indicando as principais diferenças entre elas

Vesícula biliar multisseptada: relato de um caso / Multiseplated gallblader: a case report

Os autores apresentam um caso de vesícula biliar multisseptada, revisam a literatura e comentam a raridade do achado, bem como os aspectos cirúrgicos, clínicos e embriológicos da patologia

Fibrose retroperitoneal: relato de caso / Retroperitoneal fibrosis: report of a case

Os autores relatam um caso de fibrose retroperitoneal diagnosticada por laparotomia exploradora a qual havia sido indicada por uma hipótese diagnóstica de aneurisma de aorta fissurado. Dada a raridade da doença, fazem o presente relato e revisam a literatura