[Alpha-fetoprotein--diagnostic utility in squamous cell carcinoma of the head and neck]. / Alfa-fetoproteina--diagnostyczna uzytecznosc w nowotworach zlosliwych glowy i szyi.

The authors present results of evaluation of alpha-fetoprotein (AFP) in 146 persons (108 patients with head and neck carcinoma and 38 healthy persons as control group). We analyzed a concentration of AFP in preliminary study and in monitoring depending on clinical advances of tumour, mass of primary tumour and metastases to lymph nodes. Our results indicate that evaluation of AFP have not high value in diagnostic procedures and monitoring patients with head and neck carcinoma.

[Squamous cell carcinoma antigen (Scc-Ag): diagnostic utility in squamous cell carcinoma antigen of the head and neck with metastasis to lymph nodes]. / Antygen raka plaskonablonkowego (Scc-Ag): diagnostyczna uzytecznosc w przypadkach nowotworów zlosliwych glowy i szyi z przerzutami do wezlów chlonnych.

Aim of the work was estimation of squamous cell carcinoma antigen (SCC) concentrations in serum and qualification its diagnostic value in patients with malignant neoplasm of head and neck in dependence from presence of metastasis to lymphatic glands. The study comprised the group of 146 persons (108 with head and neck malignant neoplasm, 38 of persons determined group supervisory). At 35 ill one ascertained metastasis to lymph nodes. In presented work sensitivity of SCC in initial investigation was (52.8%), specificity (97.4%), positive predicting value (PV+ = 94.2%) and negative predicting value (PV- = 64.0%). We observed not characteristic statistical dependence of concentrations SCC from presence of metastasis to lymph nodes. There was characteristic correlation between concentration of SCC and presence of metastasis to regional lymphatic glands using of correlation R-Spearman.

[Serum levels of tissue polypeptide antigen in patients with the head and neck cancer according to presence of metastases in lymph nodes]. / Stezenia tkankowego antygenu polipeptydowego u chorych na nowotwory zlosliwe glowy i szyi w zaleznosci od obecnosci przerzutów do wezlów chlonnych.

Aim of the work was estimation of Tissue Polypeptide Antigen (TPA) concentrations in serum and qualification its diagnostic value in patients with malignant neoplasm of head and neck in dependence from presence of metastasis to regional lymph nodes. The study comprised the group of 146 persons (108 with head and neck malignant neoplasm, 38 of persons determined group supervisory). At 35 ill one ascertained metastasis to lymph nodes. In presented work at ill without metastasis to lymphatic glands sensitivity of test TPA carried out 28.8%, and at ill with metastasis 42.9%, attaining 66.7% at ill from N3. One showed, that concentrations TPA grow together from spreading of neoplasm in lymph nodes, and presence of metastasis correlates with concentrations of TPA.

[Squamous cell carcinoma antigen for monitoring patients with head neoplasm]. / Antygen raka plaskonablonkowego w monitorowaniu chorych na raka glowy.

The authors present results of evaluation of squamous cell carcinoma antigen (SCC) in 73 persons (35 patients with head carcinoma and 38 healthy persons as control group). We analysed a concentration of SCC in preliminary study and in monitoring, depending on clinical advances of tumour, mass of primary tumour and metastases to lymph nodes. We observed high sensitivity (SE) (63%), high specificity (SP) (97.4%) and predictive values: positive PV(+)--95.6%, negative PV(-)--74% of SCC in preliminary study. These values changed to SE--83.3%, SP--92.3%, PV(+) 90.9%, PV(-)--85.7% in monitoring. Our results indicate that evaluation of SCC have high value in monitoring patients with head carcinoma.

[Gastrointestinal cancer antigen and immunoglobulins G, A, M in patients with head cancer]. / Ocena surowiczych stezen antygenu zoladkowo-jelitowego (Ca 19-9) oraz immunoglobulin G, A, M u chorych z nowotworami zlosliwymi glowy.

The authors present the results of examinations of immunoglobulins A, G, M serum concentrations and of a sensitivity of test of biochemical tumor marker (Ca 19-9) in a group of 35 patients with head malignant tumors. There was a statistically significant increase of immunoglobulins IgA, IgG and decrease of immunoglobulin IgM. We observed statistical correlation between serum concentrations of IgA, IgG and serum concentrations of IgA, IgM. The sensitivity of Ca 19-9 was 23% in the preliminary study. The values of Ca 19-9 changed in monitoring of tumors to 26%. There was a statistically significant correlation between sensitivity of Ca 19-9 and serum concentration of IgM. We did not observe any statistical correlation between Ca 19-9 and the age of patients.

[The value of gastrointestinal antigens in the monitoring of patients with malignant head neoplasms]. / Wartosc antygenu zoladkowo-jelitowego w monitorowaniu chorych na zlosliwe nowotwory glowy.

The authors present the results of examinations of test on the sensitivity of biochemical tumor marker (Ca 19-9) in a group of 35 patients with head malignant tumors. The sensitivity (SE) of Ca 19-9 was 22.9% in preliminary study. The values of Ca 19-9 changed from 22.9% to 25.9% in monitoring of tumors. Positive predictive value (PV+) and specify (SP) were 100% in preliminary study and in monitoring. Negative predictive value (PV-) was 50.9% in preliminary study and 51.6% in monitoring. In 25 patients we observed changes in examined parameters: SE--35%, SP--100%, PV(+)--100%, PV(-)--42.1% in monitoring. Our study indicates that serum levels of Ca 19-9 were higher in patients with head tumors than in control group. The surgical treatment of tumors didn't change the values of Ca 19-9.

[Tumor markers in monitoring of neoplasms]. / Bichemiczne znaczniki nowotworowe w monitorowaniu chorób nowotworowych.

Prophylaxis, diagnosis, radical treatment and monitoring have a basic significance in the clinic of head cancers. The aim of the clinical course of malignant disease preferred prematurely detection of the recurrence. In the monitoring wide applications have tumor markers. The authors present the results on the sensitivity of seven biochemical tumor markers (AFP, Ca-9, CEA, TPA, NSE, ferritin and SCC) in 42 patients with neoplasm of the head. The sensitivity is for AFP-0%, CEA-10%. Attention was drawn to the relatively high sensitivity for TPA, NSE, ferritin and SCC, particularly for the neoplasms of oral cavity (TPA-45%, NSE-68%, ferritin-38%, SCC-55%) and the pharynx (Ca 19-9-38%, TPA-63%, NSE-62%, ferritin-42%, SCC-83%).

[Non-Hodgkin's lymphoma: diagnostic problems]. / Chloniak z limfocytów t obwodowych--problemy diagnostyczne.

The aim of this article was to describe rarely occurred non-Hodgkin's lymphomas from peripheral lymphocyte T. Epidemiology, course of the disease and difficulties of diagnostic was described with the special regards of early diagnostic.

[A skull base tumor complicated by rhinorrhea]. / Guz podstawy czaszki powiklany plynotokiem nosowym.

The authors presented a case of rare skull base tumor complicated by rhinorrhoea. Diagnostic procedures and surgical treatment by laryngo-neurosurgical team was described.

[The prophylaxis of allergic rhinitis]. / Profilaktyka alergicznego zapalenia blony sluzowej nosa.

Authors present their own experience with prophylactic procedures applied in allergic rhinitis.

[The influence of antihistamine agents on reaction time]. / Wplyw leków przeciwhistaminowych na czas reakcji.

Authors carried out the study of reaction time on auditory stimulus in a group of 200 patients taking a single dose of: Clemastin, Phenazolinum, Zyrtec, Astemizol, Claritin, Disophrol and placebo. The results indicate the prolongation of reaction time after the administration of either first or second generation antihistaminics.

[A case of objective tinnitus]. / Przypadek obiektywnych szumów usznych.

The authors presented a case of objective tinnitus in patient with glomus tumor suspicion. Tinnitus epidemiology, classification, causes and diagnostic procedure were described. Any organic alterations, which would cause tinnitus, did not find.

[Evaluation of the differences in levels of immunoglobulin G, A,and M in the course of malignant head and neck tumors]. / Ocena róznic stezen immunoglobulin G, A, i M w przebiegu nowotworów zlosliwych glowy i szyi.

Serum levels of a variety of substances shows significant changes in head and neck cancer patients. IgG, IgA, IgM were examined in 100 patients with the head and neck cancer. Serum levels of IgG, IgA and IgM were different in variety localisation of the primary tumor. In patients with head and neck cancer medium serum levels of IgG and IgA were elevated but serum level of IgM was normal. Medium serum levels of IgG and IgA were higher in patients with another cancer than larynx cancer. Medium serum levels of IgM were highest in patients with larynx cancer.

[A case of laryngeal glandular cancer]. / Przypadek raka gruczolowego krtani.

The authors described the rare case of larynx adenocarcinoma. T3 N3 M1 tumor of larynx in 53 years old patients was monitoring by the serum levels of cancer markers: AFP, CEA, Ca 19-9, ferritin, NSE, SCC. High levels of markers were observed.

[Diagnostic difficulties in neck tumors]. / Trudnosci diagnostyczne w przypadku guzów szyi.

Neck tumors classification and accessory investigations helpful in diagnosis were presented. An attention was paid to the fact, that not seldom provisional diagnosis appeared to be wrong. Due to exact examination necessity of surgical treatment in some cases was excluded. As a proof of this three clinical cases were demonstrated.

[N2O cryotherapy in treating allergic rhinitis]. / Krioterapia N2O w leczeniu alergicznych zapalen blony sluzowej nosa.

Chronic rhinitis is known since many years to be a difficult therapeutic problem. Also new methods of treatment did not bring satisfactory good results. In our clinic a cryosurgery was applied in patients with chronic rhinitis. Performed observations indicated that cryosurgery was more successful than other conventional methods, especially in early stage of disease.