Particulate matter 1µm (PM1) dataset collected by low-cost sensors in residential and industrial areas at the neighborhood level.

The incursion of low-cost sensors (LCS) for monitoring particulate matter in different fractions of particles (PM10, PM2.5, and PM1) allows the characterization of the concentration levels of specific sources or events, including the analysis of ultrafine fractions (PM1). Several studies have documented adverse effects on human health due to exposure to PM1, such as morbidity and mortality from respiratory, cardiovascular, and, in some cases, carcinogenic diseases. Hence, studying the concentration levels and the sources that cause PM1 is imperative. LCS is an alternative to understanding contaminant concentration levels by considering spatial and temporal community dynamics by monitoring critical zones. Furthermore, collecting and managing large amounts of data through automatic processing and analysis generates information to support decision-making to reduce exposure and risks to people's health. The dataset presents the concentration level of PM1 (µg/m3) calculated from the particles of size 0.03 µm, 0.05 µm, and 1.0 µm recorded and counted by the sensor in a sample per minute for 24 h for seven continuous days. The values of the meteorological factors of relative humidity, temperature, and heat index complement these attributes. The dataset comprises records collected (in the same period) at four particulate matter monitoring stations, which compose an LCS network supported by Internet of Things (IoT) technologies. The data collection points were located in different areas of Reynosa, Mexico, considering strategic places for monitoring environmental pollution, such as industrial parks, residential areas, avenues with high vehicular traffic and transportation of heavy cargo, and an airport.

Reducing Stigma Toward People with Serious Mental Illness Through a Virtual Reality Intervention: A Randomized Controlled Trial.

Background: Stigma toward people with serious mental illnesses (SMI), like schizophrenia, is a serious global public health challenge that limits the quality of life of those affected and poses a major barrier that keeps people from seeking professional help. There is an urgent need for novel, effective, and scalable interventions to decrease stigmatized perceptions of chronic psychotic disorders and to reduce the health burden imposed by them. Method: We conducted a randomized controlled trial to assess the impact of a new immersive virtual reality game (Inclúyete-VR) on the level of stigma toward people with SMI, measured by the Attribution questionnaire (AQ-27). Participants in the experimental group were exposed in an immersive way to hallucinations common in schizophrenia, then shown different psychosocial resources available for their recovery and social inclusion; those in the control group used VR software unrelated to mental health. VR sessions were delivered through Oculus headgear and lasted 25 minutes. Results: We randomly assigned 124 university students (55% female) to experimental or control conditions (n = 62 each). We used mixed ANOVA to compare outcomes before and after the intervention between the two groups. We found a significant intervention-by-time interaction (P < 0.001), with a reduction in the experimental group of overall stigma levels on the AQ-27 scale and its three subscales: dangerousness-fear, avoidance, and lack of solidarity (P < 0.001 for all). Conclusions: The Inclúyete-VR software proved effective in the short term in reducing stigma toward people with severe mental illness. The program's longer-term efficacy, scalability, and dissemination remain to be studied. ClinicalTrials.gov Identifier: NCT05393596.

Effect of Hyaluronic Acid on the Self-Assembly of a Dipeptide-Based Supramolecular Gel.

The combination of polymers and low molecular weight (LMW) compounds is a powerful approach to prepare new supramolecular materials. Here we prepare two-component hydrogels made by a well-known and biologically active polymer, hyaluronic acid (HA), and a dipeptide-based supramolecular gelator. We undertake a detailed study of materials with different compositions including macroscopic (hydrogel formation, rheology) and micro/nanoscopic characterization (electron microscopy, X-ray powder diffraction). We observe that the two components mutually benefit in the new materials: a minimum amount of HA helps to reduce the polymorphism of the LMW network leading to reproducible hydrogels with improved mechanical properties; the LMW component network holds HA without the need for an irreversible covalent crosslinking. These materials have a great potential for biomedical application as, for instance, extracellular matrix mimetics for cell growth. As a proof of concept, we have observed that this material is effective for cell growth in suspension and avoids cell sedimentation even in the presence of competing cell-adhesive surfaces. This may be of interest to advanced cell delivery techniques.

The Use of a Closed Feed Frame for the Development of Near-Infrared Spectroscopic Calibration Model to Determine Drug Concentration.

PURPOSE: This study evaluates the use of the closed feed frame as a material sparing approach to develop near-infrared (NIR) spectroscopic calibration models for monitoring blend uniformity. The effect of shear induced by recirculation on NIR spectra was also studied. METHODS: Calibration models were developed using NIR spectra obtained in the closed feed frame for two cases. For case 2, blends that flowed through the open feed frame were predicted with the model. The shear effect of the feed frame on the blends was assessed through the characterization of powder properties before and after recirculation. RESULTS: The physical characterization of the blends confirmed that the powder properties were not altered after recirculation within the closed feed frame. Both calibration models provided highly accurate predictions of the test sets with low bias (0.03% w/w and -0.06% w/w) and relative standard error of prediction (1.9% and 3.7%), respectively. The predictive performance of the calibration models was not affected by the shear effect. CONCLUSION: Recirculation within the closed feed frame did not change the physical properties of the blends studied. The prediction of blends flowing through the open feed frame was possible with a calibration model developed in the closed feed frame. The closed feed frame could reduce the materials needed to develop calibration models by more than 90%.

Identification of Four Similar Cell Culture Media According to their Glucose, Glutamine, and Pyruvate Content by Handheld Raman Spectroscopy.

PURPOSE: This study describes the first efforts to build a spectral library to identify four cell culture media in powder form with spectra obtained with a handheld Raman spectrometer. These complex mixtures contain over 30 components and are among the most widely used cell culture media. METHODS: A total of 32 spectra were collected for the four Dulbecco's Modified Eagle Medium cell culture media and pure materials (glucose and L-glutamine) in powder form. The spectra were preprocessed using standard normal variate with second derivative, and the barcode method before performing principal component analysis (PCA). RESULTS: The PCA model differentiated the pure glucose and the cell culture media according to the glucose concentration along the first principal component. The second principal component differentiated the three cell culture media with high glucose content according to the pyruvate concentration. The correlation coefficient showed that powdered cell culture media with high glucose concentration have a higher correlation with pure glucose, when compared with the cell culture media with low glucose. CONCLUSION: The Raman spectra made it possible to differentiate the four DMEM in the cell culture media from the majority of the external samples used in the method evaluation. However, sample heterogeneity affected the predictions. Additional studies are needed to improve the method's ability to differentiate the DMEM with high glucose.

Enfrentamiento inicial de las intoxicaciones por medicamentos orales en el servicio de urgencia / Initial management of toxic exposures to oral drugs in the emergency department

Las intoxicaciones en Chile siguen siendo un motivo importante de consulta en el servicio de urgencia (SU). Tanto intoxicaciones accidentales como intencionales constituyen una fuente de morbimortalidad y gasto de recursos monetarios no solo en Chile, si no que en todo el mundo. Debido a los múltiples compuestos que pueden producir una intoxicación grave, sigue siendo un desafío para el equipo de salud su enfrentamiento y manejo oportuno. Los médicos que tratan a estos pacientes deben ser sistemáticos y ordenados en su enfrentamiento, ya que la presentación clínica es variada y depende del agente ingerido, co-ingestas, si es aguda o crónica o concomitante con otras patologías (trauma, infecciones, etc.). El manejo está dirigido a las maniobras básicas de reanimación y soporte vital, prevención de absorción del tóxico y cuando corresponda, la administración del antídoto. La evaluación y tratamiento inicial serán abordados en esta revisión, temas específicos para diferentes drogas serán discutidos de forma separada. Objetivo: entregar las nociones básicas del enfrentamiento y manejo terapéutico inicial de un paciente intoxicado desde la perspectiva de la medicina de urgencias. Método: se realizó una revisión bibliográfica de la literatura científica, presentándose la evidencia actual del manejo e intervenciones terapéuticas utilizadas actualmente de un paciente intoxicado.

In Chile, poisonings are a frequent reason for emergency department visits. Accidental and intentional poisonings constitute an important source of worldwide morbidity, mortality and health care costs. Because of the heterogeneous presentations of poisonings, and the unknown exposure, it is always challenging for healthcare providers. Doctors who treat these patients must remember to be systematic and structured in their evaluation since the clinical presentation is not only determined by the exposure itself but also by co-ingestions, the time of presentation, whether the exposure is acute or chronic, and other concomitant health issues (trauma, hypothermia, comorbidities). The management focuses on basic resuscitation and life support, prevention of absorption of the toxin, and when appropriate, administering an antidote. Initial evaluation and treatment will be addressed in this review, and specific issues for different drugs will be discussed elsewhere. Objective: to describe the basic concepts to assess and manage the initial encounter of a poisoned patient from the perspective of emergency medicine. Methods: a bibliographic review of the scientific literature was carried out, presenting the current evidence of the management and therapeutic interventions currently used in an intoxicated patient.

Evaluation of a compact composite sensor array for concentration monitoring of solutions and suspensions via multivariate analysis.

Compact composite probes were identified as a priority to alleviate space constraints in miniaturized unit operations and pharmaceutical manufacturing platforms. Therefore, in this proof of principle study, a compact composite sensor array (CCSA) combining ultraviolet and near infrared features at four different wavelengths (280, 340, 600, 860 nm) in a 380 × 30 mm housing (length x diameter, 7 mm diameter at the probe head), was evaluated for its capabilities to monitor in situ concentration of solutions and suspensions via multivariate analysis using partial least squares (PLS) regression models. Four model active pharmaceutical ingredients (APIs): warfarin sodium isopropanol solvate (WS), lidocaine hydrochloride monohydrate (LID), 6-mercaptopurine monohydrate (6-MP), and acetaminophen (ACM) in their aqueous solution and suspension formulation were used for the assessment. The results demonstrate that PLS models can be applied for the CCSA prototype to measure the API concentrations with similar accuracy (validation samples within the United States Pharmacopeia (USP) limits), compared to univariate CCSA models and multivariate models for an established Raman spectrometer. Specifically, the multivariate CCSA models applied to the suspensions of 6-MP and ACM demonstrate improved accuracy of 63% and 31%, respectively, compared to the univariate CCSA models [1]. On the other hand, the PLS models for the solutions WS and LID showed a reduced accuracy compared to the univariate models [1].

Caracterización clínica y microbiológica de los eventos de peritonitis asociada a diálisis peritoneal en un hospital de Chile. Un análisis retrospectivo / Clinical and microbiological characterization of Peritoneal Dialysis-Associated Peritonitis events in a hospital in Chile. A retrospective analysis

INTRODUCCIÓN: Las infecciones asociadas a diálisis peritoneal constituyen una de las causas de morbimortalidad más importante en estos pacientes y la terapia antimicrobiana empírica y dirigida adecuada es fundamental para mejorar el resultado, por lo que es importante establecer la microbiología local. OBJETIVO: Revisar la experiencia clínica de cinco años del Hospital Carlos Van Buren de Valparaíso, Chile, describiendo las características clínicas y microbiológicas de los pacientes con episodios de peritonitis asociada a diálisis peritoneal. METODOLOGÍA De forma retrospectiva se accedió a los registros clínicos de aquellos pacientes mayores de 18 años que presentaron al menos un evento de peritonitis asociada a diálisis peritoneal. RESULTADOS: De un total de 26 episodios, 62% de los pacientes fueron de sexo femenino, con un promedio de edad de 53 años. La principal comorbilidad fue la hipertensión arterial (100%), y el dolor abdominal fue el síntoma más frecuente (85%), con una mortalidad general de 7,7%. En el laboratorio la leucocitosis, la proteína C reactiva (PCR) y la velocidad de hemosedimentación (VHS) fueron los hallazgos más importantes. Predominaron las cocáceas grampositivas (54%), seguido de bacilos gramnegativos no fermentadores y Enterobacterales en igual proporción (11,5% cada grupo). Casos aislados de Candida albicans y Pasteurella canis fueron identificados, y en 15% de los casos el cultivo resultó negativo. CONCLUSIÓN: Se pudo conocer las características clínicas y microbiológicas locales de esta patología, para así redefinir las directrices de manejo en la institución.

BACKGROUND: Infections associated with peritoneal dialysis are one of the most important causes of morbidity and mortality in these patients, and adequate empirical and targeted antimicrobial therapy are essential to improve the outcome, so it is important to establish the local microbiology. AIM: To review the clinical experience of 5 years at the Carlos Van Buren Hospital in Valparaíso, Chile, in order to know the clinical and microbiological characteristics of patients with episodes of peritonitis associated with peritoneal dialysis. METHODS: Retrospectively, the clinical records of those patients over 18 years of age who presented at least one peritonitis event associated with peritoneal dialysis were accessed. RESULTS: Of a total of 26 episodes, 62% of the patients were female, with a mean age of 53 years. The main comorbidity was arterial hypertension (100%), and abdominal pain was the most frequent symptom (85%), with an overall mortality of 7.7%. In the laboratory parameters, leukocytosis, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were the most important findings. Gram-positive cocci (54%) predominated, followed by Gram-negative non-fermenting and enterobacterial bacilli in the same proportion (11.5% each group). Isolated cases of Candida albicans and Pasteurella canis were identified, and in 15% of the cases the culture was negative. CONCLUSION: It was possible to know the local clinical and microbiological characteristics of this pathology, in order to redefine management guidelines for our institution.

A biopsychosocial-spiritual wellness check program for internal medicine residents: A brief report.

INTRODUCTION: The pandemic has significantly impacted medical residents. We created and implemented a biannual biopsychosocial-spiritual Wellness Check Program (WCP) to help internal medicine residents self-assess for burnout, enhance resilience, and to promote early identification and referral to mental health services. We report the preliminary findings from our quality improvement pilot effort at Loma Linda University Health (LLUH). METHOD: Residents participated in biannual sessions with licensed therapists employed by Loma Linda University, Office of Physician Vitality (OPV). Visits consisted of an evidence-guided discussion about general wellbeing, relationships, family life, coping strategies, and referrals. Archived, confidential WCP session notes between July 1, 2019 and December 31, 2019 were reviewed and a simple tally system was used to record coping strategies, concerns, and referrals made. RESULTS: Partner and family issues were the most prevalent concern, followed by mental health issues, and relationships with colleagues, faculty, or staff. Most residents described several coping strategies: 66.36% listed two to three, and 26.36% listed four or more. Referrals were offered to community or employee assistance program therapists, follow-up with the OPV, psychiatry, couple counseling, given Web based psychoeducational links, or referred to their program director. Nine other residencies requested the WCP providing anecdotal evidence of its feasibility and usefulness. DISCUSSION: As the pandemic surged, these visits normalized reflections about wellbeing, intentional coping strategies, and resilience practices. We continue to gather data to refine and further structure this program and help residents monitor and address their resilience needs and wellness. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Bilateral Tessier no. 7 cleft with an accessory maxilla and osseous choristoma: a case report.

Tessier no. 7 clefts are characterized by macrostomia, facial muscular diastasis and maxillary and zygomatic bone abnormalities. It is caused by a lack of ectomesenchyme formation or penetration of the maxillary and mandibular processes during the fourth and fifth weeks of development. A case of bilateral transverse facial cleft with an accessory maxilla and an osseous choristoma is presented. The diagnosis of accessory maxilla was based on clinical findings due to the inaccessibility of orthopantomography and computed tomography scan. Orbicularis oris muscle reconstruction, cheiloplasty and excision of accessory maxilla were done. Histopathological examination of the bony lesion showed an osseous choristoma. There were no postoperative complications or local recurrence of the lesion excised. This case report demonstrates the importance of early diagnosis and intervention in maxillofacial congenital anomalies. Cheiloplasty restores function and gives the patient a natural appearance. The excision of accessory bone prevents further complications in the child's growth.

Diálisis de albúmina de paso único (SPAD) como soporte hepático extracorpóreo en paciente COVID-19 crítico. Caso clínico / Single-pass albumin dialysis as treatment of acute on chronic liver failure during COVID-19 pneumonia. report of one case

Liver transplantation is the only effective therapy to reduce the high mortality associated with acute liver failure and acute on chronic liver failure (ACLF). Single-pass albumin dialysis (SPAD) is an extracorporeal supportive therapy used as a bridge to liver transplantation or regeneration. We report a 44-year-old man with alcoholic cirrhosis admitted for critical COVID-19 pneumonia that evolves with ACLF. SPAD technique was performed completing six sessions, with a reduction of bilirubin and ammonia levels. He evolved with severe respiratory failure and refractory septic shock, dying. SPAD is a safe and efficient technique aimed to eliminate liver toxins, preventing multiorgan damage interrupting the process known as the "autointoxication hypothesis". It is easy to implement in any critical patient unit and has lower costs than other extracorporeal liver support therapies.

Análisis histórico tendencial del proceso de formación del componente investigativo en la carrera de Medicina / Historical trend analysis of the formation process of the investigative component in the Medicine career

RESUMEN Introducción: dada la complejidad creciente de los problemas de salud de la población, se hace imprescindible perfeccionar el componente investigativo en los futuros médicos para asumir este reto y actuar en correspondencia con el contexto. Objetivo: describir las tendencias que han caracterizado el proceso formativo del componente investigativo en la carrera de Medicina. Métodos: se realizó una investigación cualitativa con enfoque histórico, a partir de la revisión documental, el método cronológico y la utilización de informantes clave, como métodos predominantes para desarrollar el objetivo de este estudio. Resultados: la sistematización teórica realizada posibilitó la determinación de los hitos histórico-pedagógicos para describir los indicadores asumidos, su progreso en cada una de las etapas y dilucidar las tendencias que han caracterizado dicho proceso. Discusión: el proceso de formación del componente investigativo en la carrera de Medicina ha ido en ascenso con el perfeccionamiento de los planes y programas de estudio. Sin embargo aún persisten insuficiencias, dada entre otros factores por la no acertada proyección desde las ciencias básicas biomédicas, para comunicar los resultados de la actividad investigativa del estudiante, con el uso de las tecnologías disponibles en correspondencia con el contexto.

ABSTRACT Introduction: given the growing complexity of the health problems of the population, it is essential to improve the research component in future doctors to take on this challenge and act in correspondence with the context. Objective: to refer to the trends that has characterized the training process of the research component in the Medicine career. Methods: a qualitative research with a historical approach was carried out, based on the documentary review, the chronological sub-method and the use of key informants, as predominant methods to develop the objective of this study. Results: the theoretical systematization carried out made it possible to determine the historical-pedagogical milestones to describe the assumed indicators, their progress in each of the stages and elucidate the trends that have characterized said process. Discussion: the formation process of the investigative component in the Medicine career has been on the rise with the improvement of the study plans and programs. However, insufficiencies still persist, given, among other factors, by the unsuccessful projection from the basic biomedical sciences, to communicate the results of the student's research activity, with the use of available technologies in correspondence with the context.

An Online Community for Patient with Psoriasis with Built-in Self-Reported Questionnaires.

This study presents an online psoriasis community developed with dermatologists in a PHR. We describe the interaction of users with this platform and the relationship between the use of self-report questionnaires, their results and users' subsequent contact with the healthcare system. Out of 2175 users that interacted with the platform, 477 visited the forums. 60% of those who completed questionnaires presented at least one abnormal result that prompted a recommendation for an outpatient visit. Although our data suggest a trend, we failed to find a statistically significant association between questionnaire severity and visits scheduling. To our knowledge, this is the first study that analyses the relationship between patient self-reported disease severity and the subsequent contact with the healthcare system.

Randomized Controlled Trial of Health Coaching for Parents of Children With Medical Complexity.

BACKGROUND AND OBJECTIVE: Parents of children with medical complexity (CMCs) struggle with managing their children's care needs. Health coaching provides patients with tools to take ownership of their care. We sought to assess the impact of health coaching for parents of CMCs on activation, child's health related quality of life (HRQL), and utilization. METHODS: Parents of CMCs receiving primary care at two academic primary care practices were randomized to receive 3-6 months of coaching from a trained health coach (n = 54) or usual care (n = 71). Parents were surveyed on activation, HRQL, and experience of care at baseline and the end of the study period. Markers of utilization (missed visit rates, ED, and admissions) were measured for 12 months prior to and after enrollment. Parametric, nonparametric, and Poisson regression were used to assess baseline differences in characteristics and average pre-post differences between the groups. RESULTS: At baseline, activation and rating of patient experience were high in both groups, while HRQL was one standard deviation below the population-based mean. Both groups had slight increases in HRQL and P-PAM without significant differences between groups. ED visits declined significantly more in the intervention group than the usual care group (0.68 visits, (-0.03, -1.32) P = .04); there were nonsignificant differences in changes in other utilization metrics. CONCLUSION: Health coaching was associated with a decrease in ED use but not in changes in activation, patient experience, or HRQL. More inquiry is needed to understand whether health coaching is an effective modality for improving care for children with medical complexity.

Tratamiento a la comunicación científica desde la Disciplina Bases Biológicas de la Medicina / Treatment of scientific communication from the Discipline Biological Bases of Medicine / Tratamento da comunicação científica a partir das Bases Biológicas disciplinares da Medicina

RESUMEN La enseñanza médica en Cuba constituye el escenario ideal para la formación de las competencias que garantizan la generación y socialización de resultados investigativos contextualizados a los desafíos actuales. Durante el año 2021, se realizó un estudio descriptivo con enfoque socioformativo en la Universidad de Ciencias Médicas de Camagüey, con el propósito de develar las potencialidades de la disciplina Bases Biológicas de la Medicina (BBM) para la formación de la competencia comunicación científica. A partir del mismo se determinan las causas, carencias teóricas y prácticas que repercuten en la formación de dicha competencia desde la formación inicial en el estudiante de Medicina y su incidencia en la práctica educativa. Fueron identificadas las potencialidades de esta disciplina y su implicación en la formación de una cultura para obtener, elaborar y comunicar los resultados de la actividad investigativa como elementos básicos para la socialización científica. El trabajo metodológico del colectivo de año, enfocado en las potencialidades identificadas desde un enfoque socioformativo posibilita formar y desarrollar la competencia objeto de estudio, orientada hacia la socialización de los resultados de la actividad investigativa que realiza el estudiante durante la educación en el trabajo y actividades extensionistas.

ABSTRACT Medical education in Cuba is the ideal setting for the formation of competencies that guarantee the generation and socialization of research results contextualized to current challenges. During the year 2021, a descriptive study with a socio-formative approach was carried out at the University of Medical Sciences of Camagüey, with the purpose of revealing the potentialities of the discipline Biological Bases of Medicine (BBM) for the formation of scientific communication competence. From it, the causes, theoretical and practical deficiencies that have an impact on the formation of this competence from the initial training in the medical student and its impact on educational practice are determined. The potentialities of this discipline and its involvement in the formation of a culture to obtain, elaborate and communicate the results of the research activity as basic elements for scientific socialization were identified. The methodological work of the year group, focused on the potentialities identified from a socio-formative approach, makes it possible to train and develop the competence under study, oriented towards the socialization of the results of the research activity carried out by the student during education at work and extension activities.

RESUMO A educação médica em Cuba é o cenário ideal para a formação de competências que garantam a geração e a socialização dos resultados da pesquisa contextualizados aos desafios atuais. Durante o ano de 2021, foi realizado um estudo descritivo com abordagem socioamotiva na Universidade de Ciências Médicas de Camagüey, como objetivo de revelar as potencialidades da disciplina Bases Biológicas da Medicina (BBM) para a formação de competência de comunicação científica. A partir de la, são determinadas as causas, deficiências teóricas e práticas que impactam na formação dessa competência a partir da formação inicial do estudante de medicina e seu impacto naprática educacional. Foram identificadas as potencialidades dessa disciplina e seu envolvimento na formação de uma cultura para a obtenção, elaboração e comunicação dos resultados da atividade de pesquisa como elementos básicos para a socialização científica. O grupo metodológico do ano, focado nas potencialidades identificadas a partir de uma abordagem socioamsenária, possibilita a formação e desenvolvimento da competência em estudo, orientada para a socialização dos resultados da atividade de pesquisa realizada pelo aluno durante as atividades de ensino no trabalho e extensão.

Fisiopatología del neumomediastino espontáneo en pacientes con SARS-CoV-2: reporte de caso / Pathophysiology of spontaneous pneumomediastinum in patients with SARS-CoV-2 infection: a case report

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[Single-pass albumin dialysis as treatment of acute on chronic liver failure during COVID-19 pneumonia. report of one case]. / Diálisis de albúmina de paso único (SPAD) como soporte hepático extracorpóreo en paciente COVID-19 crítico. Caso clínico.

Liver transplantation is the only effective therapy to reduce the high mortality associated with acute liver failure and acute on chronic liver failure (ACLF). Single-pass albumin dialysis (SPAD) is an extracorporeal supportive therapy used as a bridge to liver transplantation or regeneration. We report a 44-year-old man with alcoholic cirrhosis admitted for critical COVID-19 pneumonia that evolves with ACLF. SPAD technique was performed completing six sessions, with a reduction of bilirubin and ammonia levels. He evolved with severe respiratory failure and refractory septic shock, dying. SPAD is a safe and efficient technique aimed to eliminate liver toxins, preventing multiorgan damage interrupting the process known as the "autointoxication hypothesis". It is easy to implement in any critical patient unit and has lower costs than other extracorporeal liver support therapies.