1.
Haematologica
; 89(9): 1142-4, 2004 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15377479
RESUMO
We clearly show that plasma membrane Ca2+ ATPase (PMCA) activity is lower in platelets from patients with non-insulin-dependent diabetes mellitus (NIDDM) than in those from healthy controls. The lower activity is likely due to reduced PMCA expression and increased tyrosine phosphorylation. These findings provide an explanation for the cellular ionic defects occurring in insulin resistant conditions.