RESUMO
Four nonsteroidal antiinflammatory drugs--namely, acetylsalicylic acid, naproxen, nimesulide, and dipyrone--were assayed to search their capability in preventing the hepatic increase of triacylglycerols and thiobarbituric acid reactive substances, as an indication of lipid peroxidation, resulting from the acute intoxication of rats with ethanol. The four antiinflammatory compounds inhibited the ethanol-mediated increase in triacylglycerols and thiobarbituric acid reactive substances. Furthermore, each one of these antiinflammatory drugs produced distinctive actions on blood ethanol levels: a temporal diminution with aspirin and naproxen, no changes with nimesulide, and an increase with dipyrone. It is concluded that the nonsteroidal antiinflammatory drugs contributed to controlling hepatic lipid peroxidation, and hence the oxidative stress promoted by ethanol intoxication.
Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Fígado Gorduroso Alcoólico/patologia , Metabolismo dos Lipídeos , Peroxidação de Lipídeos/efeitos dos fármacos , Tiobarbitúricos/metabolismo , Intoxicação Alcoólica/patologia , Animais , Aspirina/farmacologia , Dipirona/farmacologia , Etanol/farmacocinética , Etanol/toxicidade , Radicais Livres , Peroxidação de Lipídeos/fisiologia , Masculino , Taxa de Depuração Metabólica/efeitos dos fármacos , Taxa de Depuração Metabólica/fisiologia , Naproxeno/farmacologia , Ratos , Ratos Wistar , Sulfonamidas/farmacologia , Triglicerídeos/metabolismoRESUMO
The non-steroidal anti-inflammatory drug, piroxicam, prevents the hepatic increase of triacylglycerols and malondialdehyde resulting from the acute intoxication of rats with ethanol. In addition, in the intoxicated rats, piroxicam consistently produces a decrease in the levels of blood ethanol in comparison with control animals. It is suggested that the anti-inflammatory compound stimulates ethanol oxidation.
