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1.
PLoS One ; 15(1): e0227562, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31935248

RESUMO

We study the time evolution of the shape of a vesicle membrane under time-dependent spontaneous curvature by means of phase-field model. We introduce the variation in time of the spontaneous curvature via a second field which represents the concentration of a substance that anchors with the lipid bilayer thus changing the local curvature and producing constriction. This constriction is mediated by the action on the membrane of an structure resembling the role of a Z ring. Our phase-field model is able to reproduce a number of different shapes that have been experimentally observed. Different shapes are associated with different constraints imposed upon the model regarding conservation of membrane area. In particular, we show that if area is conserved our model reproduces the so-called L-form shape. By contrast, if the area of the membrane is allowed to grow, our model reproduces the formation of a septum in the vicinity of the constriction. Furthermore, we propose a new term in the free energy which allows the membrane to evolve towards eventual pinching.


Assuntos
Lipossomos/química , Modelos Biológicos , Bicamadas Lipídicas/química , Tensão Superficial , Termodinâmica
2.
Phys Rev E Stat Nonlin Soft Matter Phys ; 84(6 Pt 1): 061922, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22304131

RESUMO

We propose a model to describe the physical mechanisms by which chemical substances separate in the vicinity of a membrane. We assume that the adsorption of the different components of a complex liquid on a membrane is governed by interactions that couple them to the spontaneous curvature of the membrane. This problem is relevant to many fields in science, as cell constriction and division, micelles with cosurfactants, holometamorphosis, and morphogenesis in general.


Assuntos
Membrana Celular/química , Modelos Moleculares
3.
Phys Rev E Stat Nonlin Soft Matter Phys ; 73(6 Pt 2): 066308, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16906977

RESUMO

We make a numerical study of the effect that spatial perturbations have in normal Saffman-Taylor fingers driven at constant pressure gradients. We use a phase field model that allows for spatial variations in the Hele-Shaw cell. We find that, regardless of the specific way in which spatial perturbations are introduced, a lateral instability develops on the sides of the propagating Saffman-Taylor finger. Moreover, the instability exists regardless of the intensity of spatial perturbations in the cell as long as the perturbations are felt by the finger tip. If, as the finger propagates, the spatial perturbations felt by the tip change, the instability is nonperiodic. If, as the finger propagates, the spatial perturbations felt by the tip are persistent, the instability developed is periodic. In the later case, the instability is symmetrical or asymmetrical depending on the intensity of the perturbation.

4.
Phys Rev E Stat Nonlin Soft Matter Phys ; 71(1 Pt 2): 016312, 2005 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-15697727

RESUMO

We study a low-amplitude, long-wavelength lateral instability of the Saffman-Taylor finger by means of a phase-field model. We observe such an instability in two situations in which small dynamic perturbations are overimposed to a constant pressure drop. We first study the case in which the perturbation consists of a single oscillatory mode and then a case in which the perturbation consists of temporal noise. In both cases the instability undergoes a process of selection.

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