On the mechanism of kidney stone disintegration by acoustic shock waves.

In the present study we have, by theoretical and experimental investigations, especially concentrated on the importance of acoustic streaming, transient cavitation and microstreaming in the fluid close to the stone. Artificial stones, round stones 20 mm in diameter made of Plaster of Paris or rectangular flat stones, 25 x 25 x 15 mm, were suspended in a water bath at the focus of an EDAP LT01 lithotripter. "Unprotected" stones were disintegrated while stones surrounded by a layer of silicone showed no or very small disintegration. For successful destruction of the calculus, it seems to be essential that the stones are surrounded by a liquid, i.e., water.

Measurement of blood perfusion in tissue using Doppler ultrasound.

A diagnostic tool for noninvasive evaluation of microcirculatory blood flow using continuous-wave CW Doppler ultrasound is presented. In this study, the properties of this method are investigated both theoretically and experimentally. The method utilizes a nondirectional CW Doppler flowmeter. Blood perfusion in tissue is shown to be proportional to the integral integral of fS (f)df where S(f) is the Doppler power spectrum and f is the Doppler frequency. The instrumentation needed to implement the method is described. Using an experimental flow model it is demonstrated that the above integral is proportional to the product between the number of scatterers in the sample volume of the Doppler probe and the mean speed of these scatterers. This is true even for low flow velocities (down to 1 mm/s). The results from in-vivo measurements on tissues in the finger, and the calf demonstrate that the method can monitor changes in the blood perfusion. It also shows the present limitations of the method due to movement artefacts.

Acoustic impedance matching of medical ultrasound transducers.

Ultrasonic transducers for pulse-echo systems are studied both theoretically and experimentally. For the theoretical calculations the Mason model for thickness-mode disc transducers with and without backing and matching layers is used. By building several of the theoretically investigated transducer configurations it is shown that theory and experiment agree well. Thus the properties of a transducer can be predicted to a good approximation before its experimental realization. To find transducers with good sensitivity and short pulses, the pulse shape and frequency response for the following classes of transducers were studied both theoretically and experimentally: transducers with backing only, transducers with heavy backing and front matching layers, and air-backed transducers with front matching layers.

The early work of ultrasound in medicine at the University of Lund.

In the early 1950's, research was started at the University of Lund on the use of ultrasound as a diagnostic tool in cardiology, neurology, and gynecology. The results of this work provided impetus for the later development of the ultrasonic echo method into a routine procedure in many fields of medicine. A historical review of this fundamental work is given in this paper which also stresses the importance of a stimulating and free atmosphere for the development of new ideas in research.